免疫アレルギー・感染研究部

研究部紹介

気管支喘息、アトピー性皮膚炎、食物アレルギー、川崎病といった様々な免疫アレルギー疾患や、移植時の拒絶反応、先天性サイトメガロウイルス感染症をはじめとした母児感染症や重症感染症が発生する仕組みについて、疫学研究・臨床研究・基礎研究の手法を駆使して解明し、これらの疾患に対する有効な予防・治療および診断法の開発を最終的な目標として研究を行っています。

アレルギー疾患を発症する小児の割合は近年増加傾向にあります。このようなアレルギー疾患の増加には、主として環境因子と遺伝的素因が大きく関与していると考えられています。アレルギー研究室では、アレルギー疾患の発症や重症化の仕組みを明らかにし、それを応用した新たな発症予防法の開発を目指して研究を行っています。特に、近年新たに発見された自然リンパ球と組織構成細胞との相互作用に着目し、研究を行っています。また、近年報告が増えている好酸球性消化管疾患に関する病態解明研究も行なっています。

川崎病は乳幼児に好発する原因不明の全身性血管炎です。特に、心臓に血液を供給する冠動脈の炎症による後遺症（冠動脈瘤の形成）を残すことが臨床上最も重要な問題となります。当研究部では、川崎病の急性期標準治療として用いられている免疫グロブリン療法（IVIG）の冠動脈炎症に対する抗炎症効果の作用機序について、分子細胞生物学的手法を用いた解明を目指しています。この研究成果は、IVIG治療抵抗例のような重症川崎病患者に対する新たな治療戦略の確立に役立つと考えています。

移植免疫研究室では、様々な臓器移植モデル、やIn vitroの評価系を用いて、免疫寛容の誘導・維持に関与する分子・細胞の機序の解明およびCell Based Therapy を中心に、制御性T細胞、iPS細胞由来制御性樹状細胞（DC）、ミエロイド由来抑制細胞（MDSC）、間葉系幹細胞を用いる免疫制御細胞療法を確立するための基礎研究を行っています。また、新規免疫抑制剤、新規臓器保存法の開発を積極的に進めています。
母児感染研究室では、先天性サイトメガロウイルス感染症をはじめとした母児感染症について、新規感染モデルの確立、病原性発現機構の解明、および新規診断・治療法開発に向けた研究を行っています。

研究内容

研究プロジェクト

• 免疫アレルギー疾患の予防・制御方法の開発
• 単一遺伝子変異に起因する重症免疫アレルギー疾患の病態解明
• オミックス情報に基づく免疫アレルギー疾患の病態解析研究
• 自然リンパ球の活性制御機構の解明
• 好酸球性消化管疾患の病態解明
• 重症川崎病患者に対する既存治療法の炎症制御機序の解明と新規治療法の開発
• 移植免疫寛容の誘導・維持に関与する分子・細胞の機序の解明
• iPS細胞から分化誘導した制御性樹状細胞等を用いた免疫制御細胞療法の確立

研究内容

（１）疫学研究

• 横断的研究（因子分析）、コホート研究、エコチル調査研究への参画
• 責任遺伝子探索（GWAS、候補遺伝子探索・機能解析）

（２）臨床研究

• オミックス情報に基づく免疫アレルギー疾患の病態解析
• 食物蛋白誘発胃腸症/好酸球性消化管疾患の病態解析
• 食物蛋白誘発胃腸炎の疫学研究
• レセプトデータベースを用いた免疫・アレルギー疾患の実態解明研究

（３）基礎研究

• 炎症細胞（自然リンパ球、マスト細胞、好酸球）や組織細胞（上皮細胞、血管内皮細胞等）の活性化・制御に関するin vitro, in vivo研究
• 組織細胞（上皮細胞、血管内皮細胞等）の活性化・制御に関するin vitro, in vivo研究
• 神経と免疫の相互作用解析
• 免疫・アレルギー疾患の原因遺伝子変異の機能解析

スタッフ

業績

2025

1. Okata-Karigane U, Hirota M, Takahashi C, Miyagawa A, Ako R, Nakajima S, Futamura M, Yonekura S, Ogawa Y, Inomata T, Ishikawa T, Ito Y, Masaki K, Sato S, Katoh N, Morita H, Adachi T. AI-Based Objective Severity Assessment of Atopic Dermatitis Using Patient Photos in a Real-World Setting: A Digital Biomarker Approach. Allergy. 2025. In press.
2. Yamamoto-Hanada K, Kawakami E, Sato M, Irahara M, Toyokuni K, Hiraide-Kotaki E, Harima-Mizusawa N, Kubota N, Morita H, Matsumoto K, Fukuie T, Ohya Y. Interaction Between Lifestyle, Immunity and Gut Microbiota in Milk Allergy Children. Clin Exp Allergy. 2025. In press.
3. Takeuchi I, Taniguchi K, Arai K, Uchiyama T, Terao M, Hori A, Kawai T, Yoshioka T, Kyodo R, Shimizu H, Fujita S, Motomura K, Okazaki Y, Ishikawa T, Ogura M, Hayashi K, Matsumoto K, Takada S, Onodera M, Morita H, Hata K. Inflammatory bowel disease in a young female patient with a novel de novo TRAF3 frameshift variant responsive to ustekinumab: a case report. Intest Res. 2025. In press.
4. Morita H. The immune network across organs. Allergol Int. 2025;74:175-176.
5. Ver Heul AM, Mack M, Zamidar L, Tamari M, Yang TL, Trier AM, Kim DH, Janzen-Meza H, Van Dyken SJ, Hsieh CS, Karo JM, Sun JC, Kim BS. RAG suppresses group 2 innate lymphoid cells. Elife. 2025 May 6:13:RP98287. doi: 10.7554/eLife.98287.
6. Tamari M, Ver Heul AM. Neuroimmune mechanisms of type 2 inflammation in the skin and lung. Allergol Int. 2025;74:177-186.
7. Saito H, Tamari M, Fukuie T, Matsumoto K, Morita H. Direct epitope study using human IgE mAbs against peanut allergens. J Allergy Clin Immunol. 2025;155:1483-1485.
8. Adachi T, Narimatsu N, Ogawa Y, Toriya M, Fukushi T, Shirabe M, Futamura M, Inomata T, Kainuma K, Kan-O K, Kurashima Y, Masaki K, Nakajima S, Sakashita M, Sato S, Tamari M, Morita H, Koizumi A. Research team diversity impacts scientific output in allergy and immunology programs. World Allergy Organ J. 2025;18:101004.
9. Saito-Abe M, Toyokuni K, Ogasawara H, Pak K, Inuzuka Y, Harama D, Ando N, Koyano Y, Kobayashi T, Hayashi Y, Morita H, Matsumoto K, Fukuie T, Ohya Y, Yamamoto-Hanada K. KITY Study Protocol: A Randomised Controlled Trial for Eczema Prevention by Ingestion of Kestose in High-Risk Neonates. Clin Exp Allergy. 2025;55:430-432.

2024

1. Saito H, Tamari m, Motomura K, Ikutani m, Nakae S, Matsumoto K, Morita H. Omics in allergy and asthma. J Allergy Clin Immunol. 2024;154:1378-1390.
2. Akasaki Y, Iwagami M, Sung J, Nagino K, Adachi T, Morita H, Tamari M, Kainuma K, Kan-O K, Ogata H, Sakashita M, Futamura M, Kurashima Y, Nakajima S, Masaki K, Ogawa Y, Sato S, Miyagawa A, Midorikawa-Inomata A, Fujimoto K, Okumura Y, Fujio K, Huang T, Hirosawa K, Morooka Y, Nakao S, Murakami A, Kobayashi H, Inomata T. Impact of COVID-19 on care-seeking patterns for hay fever in Japan: A retrospective claims database cohort study. Allergy. 2024;79:1056-1060.
3. Motomura K, Morita H, Yamamoto H, Wada S, Sago H, Takahashi H, Saito H, Matsumoto K. Isolation of pure primary term human cytotrophoblasts and their differentiation into syncytiotrophoblast-like cells as an ex vivo model of the human placenta. Placenta. 2025;166:8-16.
4. Ando T, Takazawa I, Spencer ZT, Ito R, Tomimori Y, Mikulski Z, Matsumoto K, Ishitani T, Denson LA, Kawakami Y, Kawakami Y, Kitaura J, Ahmed Y, Kawakami T. Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-beta3-Dependent Wnt/beta-Catenin Signaling Pathway. Cells. 2024;13.
5. Motomura K, Morita H, Naruse K, Saito H, Matsumoto K. Implication of viruses in the etiology of preeclampsia. Am J Reprod Immunol. 2024;91:e13844.
6. Hanzawa S, Sugiura M, Nakae S, Masuo M, Morita H, Matsumoto K, Takeda K, Okumura K, Nakamura M, Ohno T, Miyazaki Y. The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice. Int Arch Allergy Immunol. 2024;185:752-760.
7. Hattori A, Seki A, Inaba N, Nakabayashi K, Takeda K, Tatsusmi K, Naiki Y, Nakamura A, Ishiwata K, Matsumoto K, Nasu M, Okamura K, Michigami T, Katoh-Fukui Y, Umezawa A, Ogata T, Kagami M, Fukami M. Expression levels and DNA methylation profiles of the growth gene SHOX in cartilage tissues and chondrocytes. Sci Rep. 2024;14:8069.
8. Akashi M, Kaburagi S, Kajita N, Morita H. Heterogeneity of food protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2024;73:196-205.
9. Hayashi D, Yoshida K, Akashi M, Kajita N, Tatsumoto C, Ishii T, Koike Y, Horimukai K, Kinoshita M, Hamahata Y, Nishimoto H, Sakihara T, Arakaki Y, Hara M, Noguchi E, Morita H. Differences in Characteristics Between Patients Who Met or Partly Met the Diagnostic Criteria for Food Protein-Induced Enterocolitis Syndrome (FPIES). J Allergy Clin Immunol Pract. 2024;12:1831-1839 e1831.
10. Matsumoto K. Non-IgE-mediated food allergy: Where are we now? Allergol Int. 2024;73:187.
11. Morita H, Matsumoto K. Legends of allergy and immunology: Hirohisa Saito. Allergy. 2024;79:1629-1630.
12. Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS. Sensory neurons promote immune homeostasis in the lung. Cell. 2024;187:44-61 e17.
13. Kan-O K, Noda T, Ogata H, Masaki K, Nishioka Y, Myojin T, Adachi T, Morita H, Imamura T, Tamari M, Kainuma K, Force ENT. Insights from the trends of omalizumab and mepolizumab utilization in patients with asthma: A population-based cohort study using the National Database in Japan. Respir Investig. 2024;62:113-120.
14. Okubo Y, Kuwabara Y, Sato S, Sakashita M, Yuka H, Morita H. Real-world compliance and determinants for sublingual allergen immunotherapy in children and parents. Allergy. 2024;79:523-525.
15. Suzuki H, Morisaki N, Nagashima S, Matsunaga T, Matsushita S, Iino A, Tanaka Y, Nishimori H, Munakata S, Kemmochi M, Murakami Y, Sato M, Toyokuni K, Yamamoto-Hanada K, Morita H, Fukuie T, Yamada Y, Ohtsuka Y, Arai K, Ohya Y, Saito H, Matsumoto K, Nomura I. A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants. Allergol Int. 2024;73:264-274.

2023

1. Kram YE, Sato M, Yamamoto-Hanada K, Toyokuni K, Uematsu S, Kudo T, Yamada Y, Ohtsuka Y, Matsumoto K, Arai K, Fukuie T, Nomura I, Ohya Y. Development of an action plan for acute food protein-induced enterocolitis syndrome in Japan. World Allergy Organ J. 2023;16:100772.
2. Watanabe S, Sato A, Uchida H, Kusuda R, Suzuki H, Nagashima S, Yauchi T, Matsumoto K, Ohya Y, Nomura I. Comparison of adult food protein-induced enterocolitis syndrome to crustaceans and immediate-type food allergy. Ann Allergy Asthma Immunol. 2023;131:487-493 e482.
3. Saito K, Orimo K, Kubo T, Tamari M, Yamada A, Motomura K, Sugiyama H, Matsuoka R, Nagano N, Hayashi Y, Arae K, Hara M, Ikutani M, Fukuie T, Sudo K, Matsuda A, Ohya Y, Fujieda S, Saito H, Nakae S, Matsumoto K, Akdis CA, Morita H. Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s. Allergy. 2023;78:1878-1892.
4. Motomura K, Morita H, Okada N, Matsuda A, Nakae S, Fujieda M, Sago H, Saito H, Matsumoto K. Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas. J Immunol. 2023;210:1552-1563.
5. Motomura K, Hara M, Ito I, Morita H, Matsumoto K. Roles of human trophoblasts' pattern recognition receptors in host defense and pregnancy complications. J Reprod Immunol. 2023;156:103811.
6. Hara M, Morimoto N, Watabe T, Morisaki N, Matsumoto K. Can the effectiveness of tonsillectomy for PFAPA syndrome be predicted based on clinical factors. Int J Rheum Dis. 2023;26:480-486.
7. Takeuchi I, Yanagi K, Takada S, Uchiyama T, Igarashi A, Motomura K, Hayashi Y, Nagano N, Matsuoka R, Sugiyama H, Yoshioka T, Saito H, Kawai T, Miyaji Y, Inuzuka Y, Matsubara Y, Ohya Y, Shimizu T, Matsumoto K, Arai K, Nomura I, Kaname T, Morita H. STAT6 gain-of-function variant exacerbates multiple allergic symptoms. J Allergy Clin Immunol. 2023;151:1402-1409 e1406.
8. Ando T, Kitaura J, Maruyama N, Narita M, Miura K, Takasato Y, Nogami K, Nagao M, Okumura K, Ogawa H, Onishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Hasegawa S, Ohya Y, Yasudo H. Sensitization to macadamia 7S globulin amino-terminus with clinical relevance in Japanese children with macadamia nut allergy. Allergol Int. 2023;72:351-353.
9. Furuta A, Shima T, Yoshida-Kawaguchi M, Yamada K, Yasuda I, Tsuda S, Yamaki-Ushijima A, Yoneda S, Higashisaka K, Cheng SB, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A. Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts. J Reprod Immunol. 2023;155:103766.
10. Okada N, Yazu H, Shimizu E, Fukagawa K, Nunomura S, Saito H, Matsumoto K, Kawaguchi A, Izuhara K, Fujishima H. Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis. Allergy. 2023;78:319-321.
11. Makrinioti H, Morita H, Nastouli E, Jartti T. Editorial: Bridging the gap between immunology, virology, genetics, and epigenetics in bronchiolitis: The multiomics pathway to asthma development. Front Immunol. 2023;14:1154121.
12. Nagashima S, Yamamoto M, Inuzuka Y, Irahara M, Miyaji Y, Tadaki H, Ito S, Masuda S, Ito Y, Saito Y, Kobayashi S, Morita H, Yoshioka T, Shimizu H, Arai K, Ohya Y, Saito H, Matsumoto K, Nomura I. Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis. Allergol Int. 2023;72:306-315.

2022

1. Morita H, Saito H, Matsumoto K. Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases. J Allergy Clin Immunol. 2022;149:60-62.
2. Imai T, Naruse M, Ochiai M, Matsumoto K, Ikeda S, Kani M, Kato Y, Hirayama A, Soga T, Hori Y, Yokoi A, Ochiai A. Different types of reactions to E7386 among colorectal cancer patient-derived organoids and corresponding CAFs. Oncol Lett. 2022;24:221.
3. Asano K, Tamari M, Zuberbier T, Yasudo H, Morita H, Fujieda S, Nakamura Y, Traidl S, Hamelmann E, Raap U, Babina M, Nagase H, Okano M, Katoh N, Ebisawa M, Renz H, Izuhara K, Worm M. Diversities of allergic pathologies and their modifiers: Report from the second DGAKI-JSA meeting. Allergol Int. 2022;71:310-317.
4. Yamada A, Hasegawa T, Fujieda M, Morita H, Matsumoto K. Protease-digested egg-white products induce oral tolerance in mice but elicit little IgE production upon epicutaneous exposure. Allergol Int. 2022;71:528-535.
5. Murakami S, Futamura K, Matsumoto K, Adachi Y, Matsuda A. An epidermal keratinocyte homogenate induced type 2 and proinflammatory cytokine expression in cultured dermal cells. J Dermatol Sci. 2022;106:93-100.
6. Hara M, Morimoto N, Watabe T, Inoue T, Takada N, Amari Y, Morita H, Matsumoto K. Virus-related stimuli modulate SARS-CoV-2 entry factor expression in pediatric tonsillar epithelial cells in vitro. Allergy. 2022;77:2240-2242.
7. Sato S, Kainuma K, Noda T, Ebisawa M, Futamura M, Imamura T, Miyagawa A, Nakajima S, Ogawa Y, Inomata T, Kan-O K, Kurashima Y, Masaki K, Myojin T, Nishioka Y, Sakashita M, Tamari M, Morita H, Adachi T. Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan. Allergol Int. 2022;71:354-361.
8. Adachi T, Ogawa Y, Fukushi T, Ito K, Koizumi A, Shirabe M, Toriya M, Hirako J, Inomata T, Masaki K, Sasano R, Sato S, Kainuma K, Futamura M, Kan-O K, Kurashima Y, Nakajima S, Sakashita M, Morita H, Iwamoto A, Nishima S, Tamari M, Iizuka H. Research impact analysis of international funding agencies in the realm of allergy and immunology. Allergy. 2022;77:1602-1606.
9. Yasudo H, Ando T, Kitaura J, Maruyama N, Narita M, Natsume O, Uneoka K, Miura K, Morita Y, Kamei A, Okamoto Y, Shirakawa S, Kitabayashi T, Kurihara K, Nogami K, Takasato Y, Nagao M, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Saito H, Hasegawa S, Ohya Y. Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients. J Allergy Clin Immunol Pract. 2022;10:1389-1391 e1381.
10. Akashi M, Hayashi D, Kajita N, Kinoshita M, Ishii T, Tsumura Y, Horimukai K, Yoshida K, Takahashi T, Morita H. Recent dramatic increase in patients with food protein-induced enterocolitis syndrome (FPIES) provoked by hen's egg in Japan. J Allergy Clin Immunol Pract. 2022;10:1110-1112 e1112.
11. Morita H, Matsumoto K, Saito H. Biologics for allergic and immunologic diseases. J Allergy Clin Immunol. 2022;150:766-777.
12. Kawada M, Yokoi H, Kimura T, Matsumoto Y, Sakurai H, Matsumoto K, Fujiwara M, Saito K. Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis. Allergol Int. 2022;71:83-93.
13. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Matsumoto K, Ohya Y, Japan E, Children's Study G. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). World Allergy Organ J. 2021;14:100581.
14. Matsumoto K. Valuable lessons from analyses of common signs and symptoms in rare diseases. Allergol Int. 2021;70:405-406.
15. Orimo K, Tamari M, Takeda T, Kubo T, Ruckert B, Motomura K, Sugiyama H, Yamada A, Saito K, Arae K, Kuriyama M, Hara M, Soyka MB, Ikutani M, Yamaguchi S, Morimoto N, Nakabayashi K, Hata K, Matsuda A, Akdis CA, Sudo K, Saito H, Nakae S, Tamaoki J, Tagaya E, Matsumoto K, Morita H. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions. Allergy. 2022;77:843-855.

2021

1. Yoshida M, Miyahara Y, Orimo K, Kono N, Narita M, Ohya Y, Matsumoto K, Nakagawa S, Ueki S, Morita H, Miyairi I. Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection. Chest. 2021;160:854-857.
2. Matsumoto K, Morita H, Nakae S. New insights into human atopic dermatitis provided by mouse models. J Allergy Clin Immunol. 2021;148:722-724.
3. Tsumura H, Shindo M, Ito M, Igarashi A, Takeda K, Matsumoto K, Ohkura T, Miyado K, Sugiyama F, Umezawa A, Ito Y. Relationships between Slc1a5 and Osteoclastogenesis. Comp Med. 2021;71:285-294.
4. Ito N, Tsukamoto K, Taniguchi K, Takahashi K, Okamoto A, Aoki H, Otera-Takahashi Y, Kitagawa M, Ogata-Kawata H, Morita H, Hata K, Nakabayashi K. Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for single cell sequencing-based non-invasive genetic testing. Reprod Med Biol. 2021;20:352-360.
5. Yamamoto M, Nagashima S, Yamada Y, Murakoshi T, Shimoyama Y, Takahashi S, Seki H, Kobayashi T, Hara Y, Tadaki H, Ishimura N, Ishihara S, Kinoshita Y, Morita H, Ohya Y, Saito H, Matsumoto K, Nomura I. Comparison of Nonesophageal Eosinophilic Gastrointestinal Disorders with Eosinophilic Esophagitis: A Nationwide Survey. J Allergy Clin Immunol Pract. 2021;9:3339-3349 e3338.
6. Okuzumi S, Miyata J, Kabata H, Mochimaru T, Kagawa S, Masaki K, Irie M, Morita H, Fukunaga K. TLR7 Agonist Suppresses Group 2 Innate Lymphoid Cell-mediated Inflammation via IL-27-Producing Interstitial Macrophages. Am J Respir Cell Mol Biol. 2021;65:309-318.
7. Yoshida T, Matsumoto K, Miyado M, Miyashiro Y, Sago H, Horikawa R, Fukami M. Quantification of androgens and their precursors in full-term human placenta. Eur J Endocrinol. 2021;185:K7-K11.
8. Orimo K, Tamari M, Saito H, Matsumoto K, Nakae S, Morita H. Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases. Allergy. 2021;76:3332-3348.
9. Naruse M, Ochiai M, Sekine S, Taniguchi H, Yoshida T, Ichikawa H, Sakamoto H, Kubo T, Matsumoto K, Ochiai A, Imai T. Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs. Sci Rep. 2021;11:2077.
10. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Matsumoto K, Ohya Y, On Behalf Of The Japan E, Children's Study Jecs G. Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children's Study (JECS). Nutrients. 2021;13.
11. Morita H. Immunological memory and allergic diseases. Allergol Int. 2021;70:161-162.
12. Arae K, Ikutani M, Horiguchi K, Yamaguchi S, Okada Y, Sugiyama H, Orimo K, Morita H, Suto H, Okumura K, Taguchi H, Matsumoto K, Saito H, Sudo K, Nakae S. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin. Sci Rep. 2021;11:5913.
13. Mishima S, Kashiwakura JI, Toyoshima S, Sasaki-Sakamoto T, Sano Y, Nakanishi K, Matsumoto K, Okayama Y. Higher PGD(2) production by synovial mast cells from rheumatoid arthritis patients compared with osteoarthritis patients via miR-199a-3p/prostaglandin synthetase 2 axis. Sci Rep. 2021;11:5738.
14. Emi-Sugie M, Saito H, Matsumoto K. Cultured human mast cells release various chemokines after stimulation with IL-33. Allergol Int. 2021;70:386-388.
15. Igarashi A, Matsumoto K, Matsuda A. MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells. Allergy. 2021;76:2264-2267.
16. Kashima K, Kawai T, Nishimura R, Shiwa Y, Urayama KY, Kamura H, Takeda K, Aoto S, Ito A, Matsubara K, Nagamatsu T, Fujii T, Omori I, Shimizu M, Hyodo H, Kugu K, Matsumoto K, Shimizu A, Oka A, Mizuguchi M, Nakabayashi K, Hata K, Takahashi N. Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data. Sci Rep. 2021;11:3381.
17. Sahiner UM, Layhadi JA, Golebski K, Istvan Komlosi Z, Peng Y, Sekerel B, Durham SR, Brough H, Morita H, Akdis M, Turner P, Nadeau K, Spits H, Akdis C, Shamji MH. Innate lymphoid cells: The missing part of a puzzle in food allergy. Allergy. 2021;76:2002-2016.
18. Toyoshima S, Sakamoto-Sasaki T, Kurosawa Y, Hayama K, Matsuda A, Watanabe Y, Terui T, Gon Y, Matsumoto K, Okayama Y. miR103a-3p in extracellular vesicles from FcepsilonRI-aggregated human mast cells enhances IL-5 production by group 2 innate lymphoid cells. J Allergy Clin Immunol. 2021;147:1878-1891.
19. Maeda M, Imai T, Ishikawa R, Nakamura T, Kamiya T, Kimura A, Fujita S, Akashi K, Tada H, Morita H, Matsumoto K, Katsunuma T. Effect of oral immunotherapy in children with milk allergy: The ORIMA study. Allergol Int. 2021;70:223-228.
20. Boonpiyathad T, Tantilipikorn P, Ruxrungtham K, Pradubpongsa P, Mitthamsiri W, Piedvache A, Thantiworasit P, Sirivichayakul S, Jacquet A, Suratannon N, Chatchatee P, Morisaki N, Saito H, Sangasapaviriya A, Matsumoto K, Morita H. IL-10-producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy. J Allergy Clin Immunol. 2021;147:1507-1510 e1508.
21. Suzuki H, Tsutsumi Y, Morita H, Motomura K, Umehara N, Sago H, Ito Y, Arai K, Yoshioka T, Ohya Y, Saito H, Matsumoto K, Nomura I. Cord blood eosinophilia precedes neonatal onset of food-protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2021;70:262-265.
22. Boonpiyathad T, Lao-Araya M, Chiewchalermsri C, Sangkanjanavanich S, Morita H. Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy? Front Allergy. 2021;2:747323.
23. Toyama Y, Ishii T, Morita K, Tsumura Y, Takahashi T, Akashi M, Morita H. Multicenter retrospective study of patients with food protein-induced enterocolitis syndrome provoked by hen's egg. J Allergy Clin Immunol Pract. 2021;9:547-549 e541.
24. Eljaszewicz A, Ruchti F, Radzikowska U, Globinska A, Boonpiyathad T, Gschwend A, Morita H, Helbling A, Arasi S, Kahlert H, Berek N, Nandy A, Akdis M, Willers C, Moniuszko M, Akdis CA, Sokolowska M. Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy. J Allergy Clin Immunol. 2021;147:1865-1877.

2020

1. Inoue T, Murakami S, Matsumoto K, Matsuda A. Functional benefits of corticosteroid and IVIG combination therapy in a coronary artery endothelial cell model of Kawasaki disease. Pediatr Rheumatol Online J. 2020;18:76.
2. Fujishima H, Okada N, Matsumoto K, Shimizu E, Fukuda S, Tomita M. Conjunctival Injection Reduction in Patients with Atopic Keratoconjunctivitis Due to Synergic Effect of Bovine Enteric-Coated Lactoferrin in 0.1% Tacrolimus Ophthalmic Suspension. J Clin Med. 2020;9.
3. Unno H, Arae K, Matsuda A, Ikutani M, Tamari M, Motomura K, Toyama S, Suto H, Okumura K, Matsuda A, Morita H, Sudo K, Saito H, Matsumoto K, Nakae S. Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia. Biochem Biophys Res Commun. 2020;533:493-500.
4. Fukuie T, Nishiura H, Miyaji Y, Matsumoto K, Ohya Y, Saito H. Effect of specific IgE on eliciting dose in children with cow's milk allergy. J Allergy Clin Immunol Pract. 2020;8:3660-3662 e3662.
5. Kimura N, Nomura Y, Aomatsu A, Matsuda A, Imamura Y, Taniguchi Y, Hori D, Morishita Y, Fujita H, Yuri K, Matsumoto K, Yamaguchi A. Effect of Transcatheter Aortic Valve Implantation on the Immune Response Associated With Surgical Aortic Valve Replacement. Am J Cardiol. 2020;128:35-44.
6. Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Mezawa H, Sasaki H, Nishizato M, Konishi M, Ishitsuka K, Matsumoto K, Saito H, Ohya Y, Japan E, Children's Study G. Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan. Environ Health Prev Med. 2020;25:27.
7. Adachi T, Kainuma K, Asano K, Amagai M, Arai H, Ishii KJ, Ito K, Uchio E, Ebisawa M, Okano M, Kabashima K, Kondo K, Konno S, Saeki H, Sonobe M, Nagao M, Hizawa N, Fukushima A, Fujieda S, Matsumoto K, Morita H, Yamamoto K, Yoshimoto A, Tamari M. Strategic Outlook toward 2030: Japan's research for allergy and immunology - Secondary publication. Allergol Int. 2020;69:561-570.
8. Ohno T, Nakamura T, Nakae S, Morita H, Matsumoto K, Saito H, Takeda K, Okumura K, Azuma T. TSLP is a negative regulator of RANKL-induced osteoclastogenesis. Biochem Biophys Res Commun. 2020;530:508-512.
9. Hara M, Morimoto N, Suzuki N, Tsuchihashi N, Komori M, Yoshihama K, Fujii K, Yamaguchi S, Tsunoda M, Tomisato S, Takahashi N, Oyake K, Okuba Y, Fujieda M, Matsumoto K. Transcriptome analysis reveals two distinct endotypes and putative immune pathways in tonsils from children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. Allergy. 2021;76:359-363.
10. Sokolowska M, Lukasik ZM, Agache I, Akdis CA, Akdis D, Akdis M, Barcik W, Brough HA, Eiwegger T, Eljaszewicz A, Eyerich S, Feleszko W, Gomez-Casado C, Hoffmann-Sommergruber K, Janda J, Jimenez-Saiz R, Jutel M, Knol EF, Kortekaas Krohn I, Kothari A, Makowska J, Moniuszko M, Morita H, O'Mahony L, Nadeau K, Ozdemir C, Pali-Scholl I, Palomares O, Papaleo F, Prunicki M, Schmidt-Weber CB, Sediva A, Schwarze J, Shamji MH, Tramper-Stranders GA, van de Veen W, Untersmayr E. Immunology of COVID-19: Mechanisms, clinical outcome, diagnostics, and perspectives-A report of the European Academy of Allergy and Clinical Immunology (EAACI). Allergy. 2020;75:2445-2476.
11. Radzikowska U, Ding M, Tan G, Zhakparov D, Peng Y, Wawrzyniak P, Wang M, Li S, Morita H, Altunbulakli C, Reiger M, Neumann AU, Lunjani N, Traidl-Hoffmann C, Nadeau KC, O'Mahony L, Akdis C, Sokolowska M. Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors. Allergy. 2020;75:2829-2845.
12. Matsumoto K, Saito H. Does asthma affect morbidity or severity of COVID-19? J Allergy Clin Immunol. 2020;146:55-57.
13. Emi-Sugie M, Shoda T, Futamura K, Takeda T, Ainai A, Hasegawa H, Saito H, Matsumoto K, Matsuda A. Robust production of IL-33 and TSLP by lung endothelial cells in response to low-dose dsRNA stimulation. J Allergy Clin Immunol. 2020;146:1449-1452 e1442.
14. Matsumoto K, Iikura K, Morita H, Saito H. Barrier dysfunction in the atopic march-how does atopic dermatitis lead to asthma in children? J Allergy Clin Immunol. 2020;145:1551-1553.
15. Sato M, Yamamoto-Hanada K, Tada H, Irahara M, Saito-Abe M, Matsumoto K, Pak K, Kido H, Ohya Y. Diagnostic performance of IgE avidity for hen's egg allergy in young infants. J Allergy Clin Immunol Pract. 2020;8:2417-2420 e2416.
16. Kobari S, Kusakabe T, Momota M, Shibahara T, Hayashi T, Ozasa K, Morita H, Matsumoto K, Saito H, Ito S, Kuroda E, Ishii KJ. IL-33 Is Essential for Adjuvant Effect of Hydroxypropyl-beta-Cyclodexrin on the Protective Intranasal Influenza Vaccination. Front Immunol. 2020;11:360.
17. Iwata W, Unoki-Kubota H, Kato H, Shimizu A, Matsumoto M, Imasawa T, Igarashi A, Matsumoto K, Noda T, Terauchi Y, Nangaku M, Kasuga M, Kaburagi Y. Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure. PLoS One. 2020;15:e0229397.
18. Inoue T, Miyashita M, Murakami S, Igarashi A, Motomura K, Abe J, Matsumoto K, Matsuda A. IL-1beta and IL-17A are involved in IVIG resistance through activation of C/EBPbeta and delta in a coronary artery model of Kawasaki disease. Allergy. 2020;75:2102-2105.
19. Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y. Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study. Cytokine. 2020;130:155051.
20. Orimo K, Saito H, Matsumoto K, Morita H. Innate Lymphoid Cells in the Airways: Their Functions and Regulators. Allergy Asthma Immunol Res. 2020;12:381-398.
21. Tanaka K, Nakabayashi K, Kawai T, Tanigaki S, Matsumoto K, Hata K, Kobayashi Y. Gene expression and DNA methylation changes in BeWo cells dependent on tumor necrosis factor-alpha and insulin-like growth factor-I. Hum Cell. 2020;33:37-46.
22. Okada N, Sasaki A, Saito J, Mitani Y, Yachie A, Takahashi H, Matsubara S, Tenkumo C, Tanaka H, Hata T, Motomura K, Nagasawa J, Wada Y, Sako M, Yamaguchi K, Matsumoto K, Nakamura H, Sago H, Mizuta K. The Japanese experience and pharmacokinetics of antenatal maternal high-dose immunoglobulin treatment as a prophylaxis for neonatal hemochromatosis in siblings. J Matern Fetal Neonatal Med. 2020;33:142-148.