国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

政策科学研究部

研究部紹介

政策科学研究部は、成育医療・保健に関連する情報を収集し分析することで、健全な次世代育成に資する政策提言・情報発信・研究活動を行っています。


研究内容

当研究部の四つの研究の柱を紹介します。

一つ目の研究の柱は、政策に関する理論的研究です。政策策定と評価に関する枠組み、すなわち、根拠に基づく政策の理論的背景やその適用に関する研究を行っています。これには、倫理・政治学など社会科学的側面における評価も含まれます。またグローバルヘルスに関して取り組んでいるチームもいます。

二つ目の柱は、研究統合的研究です。当研究部は日本で唯一のコクラン共同計画の正式組織であるコクラン妊娠出産グループ日本支部があり、そこで妊娠出産だけではなく全分野の系統的レビューを行うとともに作成支援も行っています。また、世界保健機関の周産期分野のガイドラインのプロジェクトマネージメントや系統的レビュー作成など技術的支援も行っています。また、費用対効果分析なども行っています。

三つ目の柱は、一次および二次データ研究です。小児慢性特定疾患登録事業の事務局として、データベースの策定と分析の技術的支援、新生児医療疾病登録(国際共同研究)や妊娠合併症疾病登録にも関わっています。日本における妊産婦のメンタルヘルスに関する縦断研究、モンゴル出生縦断研究、慢性疾患児のWellbeingに関する横断研究といった政策に資する疫学フィールド研究も行っています。また、レコードリンケージのような技術を使って、人口動態統計など政府統計を使用したデータ分析研究も行い、二回のWHO周産期全世界調査では日本の代表として貢献しています。

四つ目の柱は、政策介入研究です。以下の介入研究を行っています。

  • 新生児医療における診療の質向上クラスターランダム化比較試験
  • モンゴルにおける母子健康手帳クラスターランダム化比較試験
  • バングラデッシュにおける地域活性と施設マネージメント強化クラスターランダム化比較試験

スタッフ

政策科学研究部

政策開発研究室

政策評価研究室

部室員

  • Balogun Olukunmi(研究員)
  • 須藤 莱衣子(研究員)
  • 山本 依志子(研究員)

業績

1.      Balogun OO, Dagvadorj A, Yourkavitch J, da Silva Lopes K, Suto M, Takemoto Y, Mori R, Rayco-Solon P, Ota E. Health Facility Staff Training for Improving Breastfeeding Outcome: A Systematic Review for Step 2 of the Baby-Friendly Hospital Initiative. Breastfeed Med. 2017;12(9):537-46

2.      Chibueze EC, Parsons AJQ, Lopes KDS, Yo T, Swa T, Nagata C. Diagnostic Accuracy of Ultrasound Scanning for Prenatal Microcephaly in the context of Zika Virus Infection: A Systematic Review and Meta-analysis. 2017;7(1):2310.

3.      Chibueze EC, Tirado V, da Silva Lopes K, Balogun OO, Takemoto Y, Swa T, Dagvadorj A, Nagata C, Morisaki N, Menendez C, Ota E, Mori R, Oladapo OT. Zika virus infection in pregnancy: a systematic review of disease course and complications. Reproductive Health. 2017;14(1):28.

4.      Da Silva Lopes K, Ota E, Shakya P, Dagvadorj A, Balogun OO, Peña-Rosas JP, De-Regil LM, Mori R. Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews. BMJ Global Health. 2017;2(3):e000389.

5.      Da Silva Lopes K, Takemoto Y, Ota E, Tanigaki S, Mori R. Bed rest with and without hospitalisation in multiple pregnancy for improving perinatal outcomes. The Cochrane Library. 2017.

6.      Dagvadorj A, Nakayama T, Inoue E, Sumya N, Mori R. Cluster randomised controlled trial showed that maternal and child health handbook was effective for child cognitive development in Mongolia. Acta Paediatrica. 2017.

7.      Endo I, Takada T, Hwang TL, Akazawa K, Mori R, Miura F, Yokoe M, Itoi T, Gomi H, Chen MF, Jan YY, Ker CG, Wang HP, Kiriyama S, Wada K, Yamaue H, Miyazaki M, Yamamoto M. Optimal treatment strategy for acute cholecystitis based on predictive factors: Japan-Taiwan multicenter cohort study. J Hepatobiliary Pancreat Sci. 2017;24(6):346-61.

8.      GBD 2016 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1345-422.

9.      GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. The Lancet. 2017;390(10091):231-66.

10.    GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1260-344.

11.    GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211-59.

12.    GBD 2016 Mortality Collaborators. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084-150.

13.    Gomi H, Takada T, Hwang TL, Akazawa K, Mori R, Endo I, Miura F, Kiriyama S, Matsunaga N, Itoi T, Yokoe M, Chen MF, Jan YY, Ker CG, Wang HP, Wada K, Yamaue H, Miyazaki M, Yamamoto M. Updated comprehensive epidemiology, microbiology, and outcomes among patients with acute cholangitis. J Hepatobiliary Pancreat Sci. 2017;24(6):310-8.

14.    Delaney H, Modi N, Shoo K L, Isayama T, Gunnar S, Gagliardi L, Lehtonen L, Vento M, Kusuda S, Bassler D, Mori R, Brian R, Hakansson S, Darlow BA, Mark A, Rusconii F, Felicianoi LS, Lui K, Morisakii N, Musrapi N, S. Shahi P. Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus. Acta Paediatrica. 2017;106(3):366-74.

15.    Iwashita Y, Hibi T, Ohyama T, Honda G, Yoshida M, Miura F, Takada T, Han HS, Hwang TL, Shinya S, Suzuki K, Umezawa A, Yoon YS, Choi IS, Huang WS, Chen KH, Watanabe M, Abe Y, Misawa T, Nagakawa Y, Yoon DS, Jang JY, Yu HC, Ahn KS, Kim SC, Song IS, Kim JH, Yun SS, Choi SH, Jan YY, Shan YS, Ker CG, Chan DC, Wu CC, Lee KT, Toyota N, Higuchi R, Nakamura Y, Mizuguchi Y, Takeda Y, Ito M, Norimizu S, Yamada S, Matsumura N, Shindoh J, Sunagawa H, Gocho T, Hasegawa H, Rikiyama T, Sata N, Kano N, Kitano S, Tokumura H, Yamashita Y, Watanabe G, Nakagawa K, Kimura T, Yamakawa T, Wakabayashi G, Mori R, Endo I, Miyazaki M, Yamamoto M. An opportunity in difficulty: Japan-Korea-Taiwan expert Delphi consensus on surgical difficulty during laparoscopic cholecystectomy. J Hepatobiliary Pancreat Sci. 2017;24(4):191-8.

16.    Kiriyama S, Takada T, Hwang TL, Akazawa K, Miura F, Gomi H, Mori R, Endo I, Itoi T, Yokoe M, Chen MF, Jan YY, Ker CG, Wang HP, Wada K, Yamaue H, Miyazaki M, Yamamoto M. Clinical application and verification of the TG13 diagnostic and severity grading criteria for acute cholangitis: an international multicenter observational study. J Hepatobiliary Pancreat Sci. 2017;24(6):329-37.

17.    Kobayashi S, Hanada N, Matsuzaki M, Takehara K, Ota E, Sasaki H, Nagata C, Mori R. Assessment and support during early labour for improving birth outcomes. Cochrane Database Syst Rev. 2017;4:CD011516.

18.    Miyazaki C, Koyama M, Ota E, Swa T, Mlunde LB, Amiya RM, Tachibana Y, Yamamoto-Hanada K, Mori R. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(1):120.

19.    Miyazaki C, Tanase-Nakao K, Arata N, Mori R, Kawasaki M, Ota E. Nonpharmacological interventions to prevent type 2 diabetes in women diagnosed with gestational diabetes mellitus: a systematic overview. Diabetology International. 2017;8:160-80.

20.    Mo X, Tobe RG, Wang L, Liu X, Wu B, Luo H, Nagata C, Mori R, Nakayama T. Cost-effectiveness analysis of different types of human papillomavirus vaccination combined with a cervical cancer screening program in mainland China. BMC Infectious Diseases. 2017;17(1):502.

21.    Morisaki N, Ganchimeg T, Vogel JP, Zeitlin J, Cecatti JG, Souza JP, Pileggi Castro C, Torloni MR, Ota E, Mori R, Dolan SM, Tough S, Mittal S, Bataglia V, Yadamsuren B, Kramer MS. Impact of stillbirths on international comparisons of preterm birth rates: a secondary analysis of the WHO multi-country survey of Maternal and Newborn Health. Bjog. 2017;124(9):1346-54.

22.    Morisaki N, Zhang X, Ganchimeg T, Vogel JP, Souza JPD, Cecatti JG, Torloni MR, Ota E, Mori R, Mittal S. Provider-initiated delivery, late preterm birth and perinatal mortality: a secondary analysis of the WHO multicountry survey on maternal and newborn health. BMJ Global Health. 2017;2(2):e000204.

23.    Motomura K, Ganchimeg T, Nagata C, Ota E, Vogel JP, Betran AP, Torloni MR, Jayaratne K, Jwa SC, Mittal S, Dy Recidoro Z, Matsumoto K, Fujieda M, Nafiou I, Yunis K, Qureshi Z, Souza JP, Mori R. Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health. Sci Rep. 2017;7:44093.

24.    Nagata C, Moriichi A, Morisaki N, Gai-Tobe R, Ishiguro A, Mori R. Inter-prefecture disparity in under-5 mortality: 115 year trend in Japan. Pediatr Int. 2017;59(7):816-20.

25.    Nagata C, Moriichi A, Morisaki N, Gai-Tobe R, Ishiguro A, Mori R. Inter-prefecture disparity in under-5 mortality: 115 year trend in Japan. Pediatr Int. 2017;59(7):816-20..

26.    GBD 2016 Causes of Death Collaorators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1151-210.

27.    Ogawa R, Mori R, Iida K, Uchida Y, Oshiro M, Kageyama M, Kato Y, Tanaka T, Nakata Y, Nishimura Y. Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study. Early Human Development. 2017;115:71-6.

28.    Global Burden of Disease Health Financing Collaborators. Evolution and patterns of global health financing 1995-2014: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. The Lancet. 2017.

29.    Global Burden of Disease Health Financing Collaborators Network. Future and potential spending on health 2015-40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. The Lancet. 2017;389(10083):2005-30.

30.    GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1423-59.

31.    Sasaki H, Kakee N, Morisaki N, Mori R, Ravens-Sieberer U, Bullinger M. Assessing health-related quality of life in young Japanese children with chronic conditions: Preliminary validation of the DISABKIDS smiley measure. BMC pediatrics. 2017;17(1):100.

32.    Sasaki H, Marston J, Bouesseau M-C, Mori R. A scoping review of palliative care for children in low-and middle-income countries. BMC Palliative Care. 2017;16(1):60.

33.    Sasaki H, Yonemoto N, Mori R, Nishida T, Kusuda S, Nakayama T. Assessing archetypes of organizational culture based on the Competing Values Framework: the experimental use of the framework in Japanese neonatal intensive care units. International Journal for Quality in Health Care. 2017:1-8.

34.    Suto M, Takehara K, Yamane Y, Ota E. Effects of prenatal childbirth education for partners of pregnant women on paternal postnatal mental health and couple relationship: A systematic review. Journal of Affective Disorders. 2017;210:115-21.

35.    Tachibana Y, Miyazaki C, Ota E, Mori R, Hwang Y, Kobayashi E, Terasaka A, Tang J, Kamio Y. A systematic review and meta-analysis of comprehensive interventions for pre-school children with autism spectrum disorder (ASD). PLoS One. 2017;12(12):e0186502.

36.    Tachibana Y, Takehara K, Kakee N, Mikami M, Inoue E, Mori R, Ota E, Koizumi T, Okuyama M, Kubo T. Maternal impulse control disability and developmental disorder traits are risk factors for child maltreatment. Sci Rep. 2017;7(1):15565.

37.    Takahashi K, Ganchimeg T, Ota E, Vogel JP, Souza JP, Laopaiboon M, Castro CP, Jayaratne K, Ortiz-Panozo E, Lumbiganon P, Mori R. Prevalence of early initiation of breastfeeding and determinants of delayed initiation of breastfeeding: secondary analysis of the WHO Global Survey. Sci Rep. 2017;7.

38.    Takahashi R, Ota E, Hoshi K, Naito T, Toyoshima Y, Yuasa H, Mori R, Nango E. Fluoride supplementation (with tablets, drops, lozenges or chewing gum) in pregnant women for preventing dental caries in the primary teeth of their children. The Cochrane Library. 2017.

39.    Takehara K, Suto M, Kakee N, Tachibana Y, Mori R. Prenatal and early postnatal depression and child maltreatment among Japanese fathers. Child Abuse & Neglect. 2017;70(Supplement C):231-9.

40.    Takehara K, Tachibana Y, Yoshida K, Mori R, Kakee N, Kubo T. Prevalence trends of pre- and postnatal depression in Japanese women: A population-based longitudinal study. Journal of Affective Disorders. 2017.

41.    TanaseNakao K, Arata N, Kawasaki M, Yasuhi I, Sone H, Mori R, Ota E. Potential protective effect of lactation against incidence of type 2 diabetes in women with previous gestational diabetes mellitus: A systematic review and metaanalysis. Diabetes/Metabolism Research and Reviews. 2017.

42.    Tobe RG, Martin GR, Li F, Moriichi A, Wu B, Mori R. Cost-effectiveness analysis of neonatal screening of critical congenital heart defects in China. Medicine. 2017;96(46):e8683.

43.    The Global Burden of Disease Child and Adolescent Health Collaboration. Child and adolescent health from 1990 to 2015: findings from the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study. JAMA pediatrics. 2017(171):573-92.

44.    Wariki WMV, Ota E, Mori R, Wiysonge CS, Horvath H, Read JS. Interventions for preventing mother-to-child HIV transmission: protocol of an overview of systematic reviews. BMJ Open. 2017;7(6):e014332.

45.    Wu B, Lin H, Tobe RG, Zhang L, He B. Ticagrelor versus clopidogrel in East-Asian patients with acute coronary syndromes: a meta-analysis of randomized trials. Journal of Comparative Effectiveness Research. 2017(0).

46.    Wu B, Yang Z, Tobe R, Wang Y. Medical therapy for preventing recurrent endometriosis after conservative surgery: a cost-effectiveness analysis. BJOG: an international journal of obstetrics and gynaecology. 2017.

47.    Yamamoto S, Yamaga T, Nishie K, Nagata C, Mori R. Positive airway pressure for heart failure associated with central sleep apnoea. The Cochrane Library. 2017.

48.    Yokoe M, Takada T, Hwang T-L, Endo I, Akazawa K, Miura F, Mayumi T, Mori R, Chen M-F, Jan Y-Y, Ker C-G, Wang H-P, Itoi T, Gomi H, Kiriyama S, Wada K, Yamaue H, Miyazaki M, Yamamoto M. Descriptive review of acute cholecystitis: Japan-Taiwan collaborative epidemiological study. Journal of Hepato-Biliary-Pancreatic Sciences. 2017;24(6):319-28.

49.    Yokoe M, Takada T, Hwang TL, Endo I, Akazawa K, Miura F, Mayumi T, Mori R, Chen MF, Jan YY, Ker CG, Wang HP, Itoi T, Gomi H, Kiriyama S, Wada K, Yamaue H, Miyazaki M, Yamamoto M. Validation of TG13 severity grading in acute cholecystitis: Japan-Taiwan collaborative study for acute cholecystitis. J Hepatobiliary Pancreat Sci. 2017;24(6):338-45.

50.    Yonemoto N, Dowswell T, Nagai S, Mori R. Schedules for home visits in the early postpartum period. Cochrane Database Syst Rev. 2017;8:CD009326.

51.    Zhao Y, Zhang J, Zamora J, Vogel JP, Souza JP, Jayaratne K, Ganchimeg T, OrtizPanozo E, Hernandez B, Oladapo OT, Torloni MR, Morisaki N, Mori R, PileggiCastro C, Tunçalp Ö, Shen X, Betrán AP. Increases in Caesarean Delivery Rates and Change of Perinatal Outcomes in Lowand MiddleIncome Countries: A Hospital-Level Analysis of Two WHO Surveys. 2017;31(4):251-62.