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エコチル調査研究部

研究部紹介

10万人の母子を対象とする出生コホート調査、子どもの健康と環境に関する調査（エコチル調査）が日本全国15か所で実施されております。当研究部では、日本最大規模の出生コホート調査であるエコチル調査を医学的側面からの調査の立案・企画・実施をサポートしています。

研究内容

近年、子どもたちの間で花粉症や食物アレルギーなどのアレルギー疾患や肥満、発達障害などが増加傾向にあります。それらの多くは、身の回りの環境、食事や運動といった生活習慣、遺伝的な性質などが関連しあっているといわれています。これらの関連を解明するために、環境省が2010年度に「エコチル調査」という大規模な国家プロジェクトを開始しました。

コアセンター（国立環境研究所）を中核に全国15か所の拠点にユニットセンターを設置し、調査を実施しています。成育医療研究センター（エコチル調査研究部）は、メディカルサポートセンターとして医学的側面から調査の立案・企画・実施をサポートする役割を担っています。具体的には、医学的検査・精神神経発達検査に関連した調査方法・調査項目の検討、予備研究による検証、実施マニュアル案の作成、研修会等による検査者標準化のためのトレーニング等を担当しています。また、世界各国で行われている子供と環境に関連する調査や国際機関との連携や調査で得られた結果をいち早く社会に還元するため論文執筆などにも力を入れております。

スタッフ

エコチル調査研究部

梅澤 明弘（部長）

生体制御系計測研究プロジェクト

山本 貴和子（チームリーダー）

行動発達系計測研究プロジェクト

目澤 秀俊（チームリーダー）

遺伝子解析研究プロジェクト

熊坂 夏彦（チームリーダー）
内藤 龍彦（室長）

部室員

佐藤 未織（研究員）
西里 美菜保（研究員）
原間 大輔（研究員）
坂本 慧（研究員）
吉川 綾（研究員）
宮地 裕美子（研究員）

業績

2025

  1. Harama D, Sato M, Yang L, Miyaji Y, Mise N, Suga R, Tsuji M, Ochiai M, Oda M, Fukami M, Nakayama S F, Sekiyama M, Ohya Y, Yamamoto-Hanada K: Growth Trajectories and Body Composition in Preschoolers With Allergic Conditions: Findings From the Japan Environment and Children's Study Pilot Cohort.　Clin Exp Allergy. 2025 Jun;55(6):496-498.
  2. Miyaji Y, Yang L, Harama D, Saito-Abe M, Sato M, Sakamoto K, Nishizato M, Kumasaka N, Mezawa H, Ohya Y, Yamamoto-Hanada K. Trajectories of IgE, IgA, and IgG levels in preschool-aged children: insights from the subcohort study of the Japan Environment and Children's Study. Clin Exp Allergy. 2025 Jun 4.
  3. Yang L, Sato M, Saito-Abe M, Miyaji Y, Harama D, Sakamoto K, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y, Fukami M; Association Between Particulate Matter Exposure and Thyroid Hormone Levels in Early Childhood: Results from JECS. J Clin Endocrinol Metab 2025.
  4. Yang L, Sato M, Saito-Abe M, Miyaji Y, Harama D, Sakamoto K, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y, Fukami M; Maternal blood metal levels during pregnancy and body mass index z-score, overweight, and obesity among children: Findings of the Japan Environment and Children's Study. Environ Res 2025; 286:122755.
  5. Harama D, Saito-Abe M, Pak K, Iwamoto S, Sato M, Miyaji Y, Sakamoto K, Mezawa H, Nishizato M, Yang L, Kumasaka N, Ohya Y, Fukami M, Yamamoto-Hanada K; Japan Environment and Children's Study (JECS) Group. Not All Rhinitis Follows the Atopic March: Early-Life Risk Factors and Implications of Infectious Disease Across Three Phenotypes in JECS Cohort. Allergy. 2025 Oct 21.
  6. Mezawa H, Eguchi A, Yamamoto M, Tokuda N, Shima M, Nakayama S, Kamijima M; Japan Environment and Children's Study Group. Associations between maternal exposure to per- and polyfluoroalkyl substances and childhood neurodevelopment up to age 4: The Japan environment and children's study. Environ Int. 2025 Oct; 204:109824.

2024

  1. Yamamoto-Hanada K, Pak K, Iwamoto S, Konishi M, Saito-Abe M, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Ohya Y; Japan Environment and Children's Study (JECS) Group:　 Parental stress and food allergy phenotypes in young children: A National Birth Cohort (JECS).　　2024 Jan 25.
  2. Yamamoto-Hanada K, Ohya Y:　Overviewing allergy epidemiology in Japan-findings from birth cohorts (JECS and T-Child Study).　Allergol Int.　2024; 73:20-30

2023

  1. Saito-Abe M, Nishizato M, Yamamoto-Hanada K, Yang L, Fukami M, Itoh Y, Ihara K, Iwabuchi A, Okamoto S, Naiki Y, Ohya Y, Horikawa R. Comparison of physician- and self-assessed pubertal onset in Japanese children. Frontiers in Pediatrics. 2023.
  2. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Nomura I, Ohya Y; Japan Environment and Children's Study (JECS) Group. Prenatal antibiotic use, caesarean delivery and offspring's food protein-induced enterocolitis syndrome: A National Birth Cohort (JECS). Clin Exp Allergy. 2023 Jan 20.
  3. Ishitsuka K, Yamamoto-Hanada K, Mezawa H, Saito-Abe M, Sasaki H, Nishizato M, Sato M, Ohya Y; Japan Environment and Children's Study Group. Association between pre-pregnancy weight status and dietary patterns during pregnancy: results from the Japan Environment and Children's Study. Public Health Nutr. 2023 May 2:1-8.
  4. Yang L, Sato M, Saito-Abe M, Miyaji Y, Shimada M, Sato C, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y; Japan Environment and Children's Study (JECS) Group.　Maternal dietary zinc intake during pregnancy and childhood allergic diseases up to four years: the Japan Environment and Children's Study. Nutrients. 2023 May 30;15(11):2568.
  5. Futakawa K, Matsumura K, Tsuchida A, Konishi M, Sasaki H, Mezawa H, Yamamoto-Hanada K, Inadera H, Hasegawa T; Japan Environment and Children's Study (JECS) Group. Longitudinal study of the relationship between number of prior miscarriages or stillbirths and changes in quality of life of pregnant women: the Japan Environment and Children's Study (JECS). BMC Pregnancy Childbirth. 2023 Apr 28;23(1):297.
  6. Yang L, Sato M, Saito-Abe M, Miyaji Y, Sato C, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y; Japan Environment and Children's Study (JECS) Group.
    Congenital hypothyroidism and thyroid function in a Japanese birth cohort: data from the Japan Environment and Children's Study. Clin Pediatr Endocrinol. 2023.
  7. Fujita N, Mezawa H, Pak K, Uemura O, Yamamoto-Hanada K, Sato M, Saito-Abe M, Miyaji Y, Yang L, Nishizato M, Ohya Y, Ishikura K, Hamasaki Y, Sakai T, Yamamoto K, Ito S, Honda M, Gotoh Y; Japan Environment, Children's Study Group. Reference blood pressure values obtained using the auscultation method for 2-year-old Japanese children: from the Japan Environment and Children's Study. Clin Exp Nephrol. 2023 Jun 30.
  8. Sasaki H, Pak K, Mezawa H, Yamamoto-Hanada K, Ishitsuka K, Konishi M, Nishizato M, Sato M, Saito-Abe M, Yang L, Ohya Y ; Japan Environment, Children's Study (JECS) Group: Health-related quality of life of mothers and developmental characteristics of very low birth weight children at 2.5 years of age; results from the Japan Environment and Children's Study (JECS). Health Qual Life Outcomes. 2023 Jul 10;21(1):68.
  9. Miyaji Y, Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Mezawa H, Nishizato M, Ochiai M, Ohga S, Oda M, Mitsubuchi H, Shimono M, Suga R, Mise N, Sekiyama M, Nakayama SF, Ohya Y; Japan Environment and Children's Study (JECS). Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children's Study cohort. BMC Pediatr. 2023 Sep 21;23(1):479.
  10. Yamamoto M, Mezawa H, Sakurai K, Mori C, Japan Environment and Children's Study Group. Screen Time and Developmental Performance Among Children at 1-3 Years of Age in the Japan Environment and Children's Study. JAMA Pediatr. Published online September 18, 2023.

2022

  1. Irahara M, Yamamoto-Hanada K, Saito-Abe M, Sato M, Miyaji Y, Yang L, Mitsubuchi H, Oda M, Sanefuji M, Ohga S, Ikegami A, Mise N, Suga R, Shimono M, Yamazaki S, Nakayama SF, Ohya Y. Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment and Children's Study pilot cohort. Allergol Int. 2022
  2. Yamamoto M, Mezawa H, Sakurai K, Mori C. Association between Media Use and Bedtime Delays in Young Children: An Adjunct Study of the Japan Environment and Children's Study. International Journal of Environmental Research and Public Health. 2022; 19(15):9464.
  3. Yang L, Sato M, Saito-Abe M, Miyaji Y, Sato C, Nishizato M, Kumasaka N, Mezawa H, Yamamoto-Hanada K, Ohya Y. Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children's Study. Nutrients. 2022; 14(15):3121
  4. Yang, L.; Sato, M.; Saito-Abe, M.; Miyaji, Y.; Shimada, M.; Sato, C.; Nishizato, M.; Kumasaka, N.; Mezawa, H.; Yamamoto-Hanada, Ohya Y, On Behalf Of The Japan Environment and Children's Study Jecs Group. Allergic Disorders and Risk of Anemia in Japanese Children: Findings from the Japan Environment and Children's Study. Nutrients. 2022; 14(20):4335.
  5. Saito-Abe M, Yamamoto-Hanada K, Pak K, Iwamoto S, Sato M, Miyaji Y, Mezawa H, Nishizato M, Yang L, Kumasaka N, Kobayashi T, Ohya Y; Japan Environment and Children's Study (JECS) Group. How a family history of allergic diseases influences food allergy in children: the Japan Environment and Children's Study. Nutrients. 2022 Oct 15;14(20):4323.

2021

  1. Ogawa K, Pak K, Yamamoto-Hanada K, Ishitsuka K, Sasaki H, Mezawa H, Saito-Abe M, Sato M, Yang L, Nishizato M, Konishi M, Sago H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Association between maternal vegetable intake during pregnancy and allergy in offspring: Japan Environment and Children's Study. PLoS One. 2021 Jan 28;16(1): e0245782.
  2. Saito-Abe M, Yamamoto-Hanada K, Pak K, Sato M, Irahara M, Mezawa H, Sasaki H, Nishizato M, Ishitsuka K, Konishi M, Yang L, Ohya Y, Suzuki K; Japan Environment and Children's Study (JECS) Group. Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study. Int Arch Allergy Immunol. 2021 Feb 18:1-13
  3. Yamamoto-Hanada K, Pak K, Saito-Abe M, Sato M, Ohya Y; Japan Environment and Children's Study (JECS) Group. Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: a birth cohort. Ann Allergy Asthma Immunol. 2021 Jun;126(6):713-721.
  4. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Matsumoto K, Ohya Y; Japan Environment and Children's Study (JECS) Group.　Association of hemoglobin and hematocrit levels during pregnancy and maternal dietary iron intake with allergic diseases in children: the Japan Environment and Children's Study.　Nutrients. 2021; 13:810.
  5. Ishitsuka K, Sasaki S, Mezawa H, Konishi M, Igarashi M, Yamamoto-Hanada K, Nakayama SF, Ohya Y. Dietary supplement use in elementary school children: a Japanese web-based survey. Environ Health Prev Med. 2021 Jun 5;26(1):63.
  6. Yang L, Sato M, Saito-Abe M, Nishizato M, Mezawa H, Yamamoto-Hanada K, Ohya Y, The Japan Environment and Children's Study Jecs Group. Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study. Nutrients. 2021 Aug 12;13(8):2761.
  7. Igarashi M, Ayabe T, Yamamoto-Hanada K, Matsubara K, Sasaki H, Saito-Abe M, Sato M, Mise N, Ikegami A, Shimono M, Suga R, Ohga S, Sanefuji M, Oda M, Mitsubuchi H, Michikawa T, Yamazaki S, Nakayama S, Ohya Y, Fukami M. Female-dominant estrogen production in healthy young children before adrenarche. Endocr Connect. 2021 Sep 1:EC-21-0134.R1.
  8. Yang L, Sato M, Saito-Abe M, Ohya Y, et al. Hypertensive disorders of pregnancy and risk of allergic conditions in children: Findings from the Japan Environment and Children's study (JECS). World Allergy Organization Journal. 2021;14(9).
  9. Yamamoto-Hanada K, Suzuki Y, Yang L, Saito-Abe M, Sato M, Mezawa H, Nishizato M,　Kato N, Ito Y, Hashimoto K, Ohya Y; Japan Environment and Children's Study (JECS) Group. Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort. PLoS One. 2021 Dec 1;16(12):e0260447
  10. Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H, Konishi M, Ishitsuka K, Mezawa H, Yamamoto-Hanada K, Ohya Y; Japan Environment and Children's Study (JECS) Group. 25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children's study (JECS). BMC Pediatr. 2021 Dec 2;21(1):539.

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