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Division of Immunology
Our division specializes in immune deficiencies caused by immune dysfunction or dysregulation. We manage susceptible patients and develop innovative medical approaches for treatment.
Specialists in immunology and rheumatology assess patients with immune deficiencies and provide a comprehensive diagnosis and appropriate therapy in consultation with the NCCHD’s research institute.
Diagnosis and treatment policy
We administer general treatments to patients based on medical evidence. For patients with a more severe phenotype, we also offer advanced medicine such as gene therapy, enzyme replacement therapy, cytokine therapy, or anti-immune therapy.
Flow cytometric analysis, cell function assay, genetic analysis, and measurement of enzyme activity are conducted for diagnosis and assessment of disease severity.
Prophylactic therapy using antibiotics, antifungal drugs, immunoglobulin, PEG-ADA, or interferon gamma is administered to patients with immunodeficiencies depending on their clinical symptoms. Immunomodulation therapy with immunosuppressive drugs and biological agents is also used to treat autoinflammatory syndrome and autoimmune disorders.
Clinical trial and research
To develop a safe and effective medical approach for patients with immunodeficiencies, we have devised clinical protocols for hospital staff and published the data obtained from protocols in scientific journals.
- Severe combined immunodeficiency
- Antibody deficiencies
- Diseases of immune dysregulation
- Defects of phagocyte number or function
- Gene therapy: Since 2004 our division has been involved in the development of gene therapy for X-linked chronic granulomatous disease (CGD), an ongoing project conducted in collaboration with the National Institute of Health in the US.