国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

Division of Advanced Medicine for Virus Infections

We aim to develop novel strategies for the diagnosis and treatment of pediatric infectious diseases caused by the herpes virus. We also intend to translate the latest results of molecular virology into clinical practice. Epstein-Barr virus (EBV) is the primary target of our research.

The main responsibilities of our department are:

Generating mouse models for diseases associated with EBV

EBV causes a number of diseases in children, such as infectious mononucleosis, chronicactive EBV infection, and white blood cell or lymphoproliferative diseases in patients with compromised immune systems. We utilize ‘humanized mouse’ technology to prepare mouse models of EBV infection that are suitable for the evaluation of drugs and vaccines. Humanized mice are prepared by reconstituting human immune system components in immunodeficient mice. These mice are then able to be infected with EBV and reproduce EBV-associated diseases, such as lymphoproliferative disease. By using this model, we are able to evaluate novel drugs and therapies to treat EBV.

Diagnosis of virus infections

We routinely undertake molecular diagnosis of various virus infections. In particular, we practice molecular EBV monitoring in transplant recipients and identify EBV-infected cells for the diagnosis of chronic active EBV infection. We also use rapid assay technology to diagnose childhood viruses (except EBV) including herpes simplex types 1 and 2, cytomegalovirus, human herpes virus types 6 and 7, and hepatitis B virus, among others.

Development of highly advanced medical techniques and treatments

Our department is devoted to the development of new therapeutic drugs to treat virus infections, new diagnostic procedures and therapies