国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

Division of Radiation Safety

Our division investigates the fundamental events of immune cells during immune response to transplantation antigens and ischemia/reperfusion injury. We aim to understand the basic processes that control T-cell activation and tolerance, and develop novel immunosuppressive agents, antibodies, and siRNA using rodent heart and liver transplantation models. We have also proposed several new approaches for cell-based immunotherapy, including iPS-cell-derived regulatory dendritic cells, myeloid-derived suppressor cells, mesenchymal stem cells, and gene therapy in transplant rejection. Furthermore, we have developed a novel non-invasive positron emission tomography (PET) imaging method for the evaluation of acute allograft rejection and immunosuppressive therapy efficacy. We are currently building a biomarker search system for liver transplantation patients.

Through our research, we aim to:

  1. Gain mechanistic insights into immune tolerance induction and maintenance;
  2. Establish new approaches for cell-based immunotherapy;
  3. Develop novel biomarkers and methods for transplant rejection diagnosis;
  4. Create novel immunosuppressive agents, antibodies, siRNA, etc.;
  5. Devise new solutions and methods for organ preservation.