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Division of Radiation Safety
We provide education and
information on research activities related to radioisotopes, such as the safety
measures in place at facilities, notifications of radioisotope use, changes,
and permits as well as the health management of the users and safety guidance
and information.
Research focus:
Our
division investigates the fundamental events occurring in immune cells during
an immune response to transplant antigens and ischemia/reperfusion injuries. We
aim to understand the basic processes that control T-cell activation and
tolerance and develop novel immunosuppressive agents, antibodies, and siRNA
using rodent organ transplantation models and in vitro systems. In addition, we
have proposed several new approaches for cell-based immunotherapy, including
regulatory T cells, iPS-cells-derived regulatory dendritic cells,
myeloid-derived suppressor cells, and mesenchymal stem cells in transplant
rejection and autoimmune diseases. Furthermore, we are promoting basic research
to develop new anticancer drugs using cancer models and to elucidate their
mechanism of action.
Members
Leaders
- Xiao-Kang Li
Chief, Division of Transplantation Immunology / Division of Radiation Safety
Researchers
- Hu Xin
Bibliography
2021
1.
Ma K, Que WT, Hu X, Guo WZ, Gu EL, Zhong L, Morello
V, Cazzanti M, Michieli P, Takahara T, Li Xiao K*. A MET-agonistic
antibody accelerates cirrhotic liver regeneration and improves mouse survival
following partial hepatectomy. Liver Transplant (In press).
2.
Shui YF, Hu X, Hirano H, Kusano K, Tsukamoto H, Li MQ, Hasumi K, Guo WZ, Li Xiao K*. β-glucan
from Aureobasidium pullulans augments the anti-tumor immune responses through
activated tumor-associated dendritic cells. Int Immunopharmacol (In press).
3.
Du XX, Que WT, Hu X, Yu X, Guo WZ, Zhang SJ, Li Xiao K*. Oridonin prolongs the survival of mouse cardiac
allografts by attenuating the NF-κB/NLRP3 pathway. Frontiers
in Immunology 12: 719574; 2021.
4. Hu X, Que
WT, Hirano H, Wang ZD, Nozawa N, Ishii T, Ishizuka M, Ito
H, Takahashi K, Nakajima M, Tanaka T, Zhu P, Guo WZ, Li Xiao K*. 5-ALA/SFC enhanced the antitumor effects of
PD-L1 blockade via regulated exhaustion T cell metabolism in melanoma model. Cancer
Science 112(7):2652-2663; 2021.
5.
Matsuda Y, Watanabe T. Li Xiao K. Approaches for Controlling
Antibody-Mediated Allograft Rejection Through Targeting B cells. Frontiers in Immunology 12: 682334; 2021.
6. Wang Z, Ma K, Fujino
M, Kusano K, Yi
SQ, Iwai A, Li Xiao K*. The effects of oral administration of Aureobasidium pullulans-cultured fluid
containing β-glucan on concanavalin A injection in mice. Heliyon
7(6): e07277;
2021.
7. Liu
C, Wang ZD, Hu X, Ito H, Takahashi
K, Nakajima M, Tanaka T, Zhu
P, Li Xiao K*. 5-aminolevulinic
acid combined with sodium ferrous citrate ameliorated lupus nephritis
in a mouse chronic graft-versus-host disease model. Int Immunopharmacol 96:107626; 2021.
8. Zheng
QY, Zhang SJ, Guo WZ, Li
Xiao K*. The unique immunomodulatory properties of MSC-derived
exosomes in organ transplantation. Frontiers in
Immunology 12: 659621; 2021.
9. Hirano S, Aoki
Y, Kurokawa R, Li
Xiao K, Ichimaru N, Takahara S, Takefuji Y. Protective effects of hydrogen
gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective
observational study. Medical Gas Research 11(3):104-109; 2021.
10. Li SW, Takahara T, Que WT, Fujino M, Guo WZ, Hirano S, Ye LP, Li Xiao K*. Hydrogen-rich water protects liver injury in
nonalcoholic steatohepatitis though HO-1 enhancement via IL-10 and Sirt 1
signaling. Am J Physiol Gastrointestinal
and Liver Physiol 320(4): G450-463; 2021.
11. Que
WT, Li Xiao K*. Regulatory T
Cells for the Induction of Transplantation Tolerance. In: SG-Zheng editor. Chapter
15: T Regulatory Cells in Human Health and Diseases. Springer Publishers
Inc., pp.289-302, 2021.
12. Zhao J, Que
WT, Du XX, Fujino M, Ichimaru N, Ueta H, Tokuda N, Guo WZ, Zabrocki P, Haard HD,
Nonomura N, Li Xiao K*. Monotherapy with anti-CD70 antibody causes
long-term mouse cardiac allograft acceptance with induction of tolerogenic
dendritic cells.
Frontiers in Immunology 11: 555996; 2021.
13. Matsuda
Y, Hiramitsu T, Li Xiao K, Watanabe
T. Characteristics of immunoglobulin M type antibodies of different origins from the immunologic and clinical viewpoints and their application
in controlling antibody-mediated allograft
rejection. Pathogens 10(1), 4; 2021.
2020
14. Wang ZD, Ma
K, Liu C, Hu X, Que WT, Ito H, Takahashi K, Nakajima M, Tanaka T, Ren K, Guo WZ,
Yi SQ, Li Xiao K*. 5-Aminolevulinic acid combined
with sodium ferrous ameliorated liver injury in a murine acute graft-versus-host
disease model by reducing inflammation responses through PGC-1α activation. Drug
Discoveries & Therapeutics 14(6):304-312; 2020.
15. Que
WT, Guo WZ, Li Xiao K*. Manipulation
of regulatory dendritic cells for induction transplantation tolerance. Frontiers in Immunology 11:582658; 2020.
16. Que
WT, Hu X, Fujino M, Terayama H, Sakabe K, Fukunishi N, Zhu P, Yi SQ, Yamada Y, Zhong L, Li Xiao K*. Prolonged cold ischemia time
in mouse heart transplantation using supercooling preservation.
Transplantation 104(9): 1879-1889; 2020.
17. Jiang YZ,
Que WT, Zhu P, Li Xiao
K*. The role of
diverse liver cells in liver transplantation tolerance. Frontiers in
Immunology 11:1203; 2020.
18. Sheng C, Li Xiao K*. The role of immune modulation in pathogenesis
of IgA nephropathy. Frontiers in
Medicine 7:92; 2020.
19. Wang
PP, Zhao MY, Chen ZH, Wu GJ, Fujino M, Chen Zhang C, Zhou WJ, Zhao MW, Hirano
S, Li Xiao K*,
Zhao LL. Hydrogen gas attenuates hypoxic-ischemic brain injury via regulation
of the MAPK/ HO-1/PGC-1α pathway in neonatal rats. Oxid Med Cell Longev. 2020:6978784; 2020.
20. Wang J, Liu C, Que W, Fujino M, Tong G, Yan H, Li Xiao K*. Immunomodulatory effects
of Salvianolic acid B in a spontaneous abortion mouse model. J
Reprod Immunol. 137:103075. 2020.
2019
21. Liu C, Fujino M, Zhu S, Isaka Y, Ito H, Takahashi K, Nakajima
M, Tanaka T, Zhu P, Li
Xiao K*. 5-ALA/SFC enhances HO-1 expression through the MAPK/Nrf2
antioxidant pathway and attenuates murine tubular epithelial cell apoptosis. FEBS Open Bio. 9(11): 1928-1938; 2019.
22. Liu C, Zhu P, Fujino M, Zhu S, Ito H, Takahashi
K, Nakajima M, Tanaka T, Zhuang J, Li Xiao K*. 5-ALA/SFC attenuated binge alcohol-induced gut leakiness and
inflammatory liver disease in HIV transgenic rats. Alcohol Clin Exp Res. 43(8): 1651-1661; 2019.
23. Wang J, Liu C, Fujino M, Tong G, Zhang Q, Li Xiao K*, Yan
H. Stem cells as a resource for treatment
infertility-related diseases. Curr Mol Med. 19(8):
539-546; 2019.
24. Wu G, Chen Z, Wang P, Zhao M, Fujino M, Zhang C, Zhou W,
Hirano SI, Li Xiao K, Zhao
L. Hydrogen inhalation protects
hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in
neonatal rats. Exp Biol Med. 244(12): 1017-1027; 2019.
25. Zhao J, Yang XC, Fujino M, Ichimura N, Que WT,
Li Xiao K*, Takahara S. Salvianolic
acid B ameliorates liver injury in a murine aGvHD model by decreasing inflammatory
responses via upregulation of HO-1. Transpl
Immunol. 55: 101203; 2019.
26. Toyama S, Migita O, Fujino M, Kunieda T,
Kosuga M, Fukuhara Y, Nagahara Y, Li Xiao K*.
Okuyama T. New treatment method for mucopolysaccharidosis type VI by liver
transplantation. Pediatr Int. 261(2):
180-189; 2019.
27. Wang Y, Zenkoh J, Gerelchuluun A, Sun
L, Cai S, Li Xiao K, Tsuboi K. Administration
of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors into
Effective in situ Vaccines. Int J Radiat Oncol
Biol Phys. 103(4): 958-969; 2019.
28.
Uto K, Sakamoto S, Que WT,
Shimata K, Hashimoto S, Sakisaka M, Narita Y, Daiki Y, Zhong L, Yoshihiro K, Kurokawa R, Li Xiao K, Inomata Y, Hibi T. Hydrogen rich
solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
BMC Gastroenterol. 19(1):
25; 2019.
29. Liu C, Zhu P, Fujino M, Isaka Y, Ito H, Takahashi K, Nakajima
M, Tanaka T, Zhuang J, Li Xiao K*. 5-aminolaevulinic acid (ALA), enhances heme oxygenase
(HO)-1 expression and attenuates tubulointerstitial fibrosis and renal
apoptosis in chronic cyclosporine nephropathy. Biochem
Biophys Res Commun. 508(2): 583-589; 2019.
2018
30. Liu C, Yang X, Zhu P, Fujino M, Ito H, Takahashi K, Nakajima
M, Tanaka T, Wang J, Zhuang J, Zou HJ, Li Xiao K*. Combination of 5-aminolaevulinic acid and iron prevents skin
fibrosis in murine sclerodermatous grafts-versus-host disease. Exp Dermatol. 27(10): 1104-1111; 2018.
31. Li S, Fujino M, Ichimaru N, Kurokawa R, Hirano S, Mou L,
Takahara S, Takahara T, Li
Xiao K*. Molecular hydrogen protects against
ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1
and Sirt1 expression. Sci Rep. 8(1): 14019; 2018.
32. Li S, Fujino M, Takahara T, Li Xiao K*. Protective role of heme oxygenase-1
in fatty liver ischemia-reperfusion injury. Med Mol Morphol. Aug 31. 2018.
33. Zhao M, Yang M, Que W, Zhong L, Fujino M, Li Xiao K*. Myeloid heme oxygenase-1: a new therapeutic target in anti-inflammation.
Front Biosci. 23:2001-2015; 2018.
34. Ito H,
Nishio Y, Hara T, Sugihara H, Tanaka T, Li Xiao K.
Oral
administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in
peripheral blood mononuclear cells of healthy human subjects in combination
with ferrous iron. Eur
J Pharmacol. 833: 25-33; 2018.
35. Hatayama N, Hirai S, Naito M, Terayama H, Araki J, Yokota H,
Matsushita M, Li Xiao K, Itoh M. Preservation of rat
limbs by hyperbaric carbon monoxide and oxygen. Sci Rep. 8(1):
6627; 2018.
36. Joyce D, Fujino M, Morita M, Araki R, Fung J,
Qian S, Lu L, Li Xiao
K*. Induced pluripotent stem
cells-derived myeloid-derived suppressor cells regulate the CD8+ T
cell response. Stem
Cell Res. 29:32-41; 2018.
37. Zhou WC, Wang Y, Fujino M,
Shi LM, Jin L, Li Xiao
K*, Wang JC. A standardized fold change (SFC) method for microarray
differential expression analysis used to reveal genes involved in acute
rejection in murine allograft models.
FEBS Open Bio 8(3):
481-490; 2018.
2017
38. Li S, Takahara T, Fujino M, Fukuhara Y, Sugiyama T, Li Xiao K*, Takahara S. Astaxanthin prevents ischemia-reperfusion injury of the
steatotic liver in mice. PLoS One. 12(11): e0187810; 2017.
39. Yang
X, Liu C, Fujino M, Yang J, Li Xiao K*, Zou HJ. A modified graft-versus-host-induced
model for systemic sclerosis, with pulmonary fibrosis in Rag2-deficient mice. FEBS Open Bio 7(9): 1316-1327; 2017.
40. Cai
SJ, Hou JG, Fujino M, Zhang Q, Ichimaru N, Takahara S, Araki R, Lu L, Chen JM,
Zhuang J, Zhu P, Li Xiao K*. iPSC-derived Regulatory Dendritic Cells Inhibit
Allograft Rejection via Generating Alloantigen-specific Regulatory T Cells. Stem Cell Reports 8(5):
1174-1189; 2017.
41. Yang XC,
Fujino M, Cai SJ, Li SW, Liu, C, Li Xiao K*. Genetic polymorphisms of
cytotoxic T-lymphocyte antigen 4 in primary biliary cholangitis: a meta-analysis.
Journal of Immunology Research 2017:5295164; 2017.
42. Abe
T, Yazawa K, Fujino M, Imamura R, Hatayama N, Kakuta Y, Tsutahara K, Okumi M,
Ichimaru, Kaimori J, Isaka Y, Seki K, Takahara S, Li Xiao K*, Nonomura.
N High-pressure carbon monoxide preserves rat kidney grafts from apoptosis and
inflammation. Lab Invest 97(4): 468-477; 2017.