国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

Department of Pharmacology

We investigate therapeutic targets for pediatric disorders and are currently developing more efficient and effective toxicological testing.

Our Experimental Pharmacological Laboratory analyzes the pathogenesis of pediatric diseases using tissue and cell samples from patients to evaluate drug therapies and develop drug toxicity testing, while our Molecular Pharmacology Laboratory investigates therapeutic targets for congenital disorders. Our research encompasses the following areas:

1. Development of cell therapy and drug discovery research using tissues and cells derived from patients

We isolate cells from the liver and utilize them to develop cell culture methods for drug discovery and cell therapy.

2. Development of in vitro drug toxicity tests and drug evaluation

We develop in vitro drug toxicity tests and drug evaluation methods using ES cells, iPS cells and hepatocytes.

3. Search for disease-related molecules in pediatric hepatobilliary diseases and development of drug therapy

We seek to identify disease-related molecules in pediatric hepatobilliary diseases and develop novel drug therapies.

4. Studies on mechanism underlying congenital neuronal disorders

We investigate how and why congenital neuronal disorders occur, as well as what therapeutic targets are effective for these disorders.

5. Studies on mechanism underlying neuropathic pain

We investigate how and why neuropathic pain occurs, as well as what therapeutic targets are effective for pain.

6. Development of animal models for congenital disorders

We generate model mice for congenital disorders and investigate their potential therapeutic targets.