国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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Scholar & Enterprise

Scholar & Enterprise

Department of Allergy and Clinical Immunology

Our mission is to clarify the precise pathogenic mechanisms of various immunological and allergic diseases, such as Kawasaki disease (KD), various allergic diseases, allogenic immune tolerance, congenital viral infections and severe infectious diseases. To achieve this, we employ various experimental approaches, including epidemiology, clinical and basic research. Our ultimate aim is to develop better means of preventing, diagnosing and treating allergic and immunological and infectious diseases based on our research findings and cumulative knowledge.

Research approach

We conduct basic research, epidemiologic studies and clinical studies in cooperation with each section of the NCCHD. We also promote collaborations between domestic and international researchers.

Research focus

The prevalence of allergic diseases has been steadily increasing, and several environmental factors are thought to be key contributors to this increase. Better understanding of the pathogenic mechanisms involved in the development, exacerbation and perpetuation of allergic inflammation will help us develop novel primary prevention strategies.

KD is an acute febrile illness that preferentially affects the coronary arteries and involves inflammation of the blood vessels. Through collaborative research with specialist doctors at the hospital, we identified several biomarkers for diagnosis and prediction of severe KD using DNA-microarray technology. We also aim to elucidate the precise molecular mechanisms underlying intravenous immunoglobulin (IVIG) therapy. In addition, we are involved in multi-center genetic research projects across Japan.Immunological development towards reaction or tolerance is critically important for the rejection/tolerance of transplanted organs. We utilize various in vitro/in vivo models to develop novel therapeutic intervention strategies such as iPS-derived dendritic cells,
immunosuppressing drugs and more.

We also study infectious diseases caused by mother-to-child transmission of pathogens such as congenital cytomegalovirus (CMV) infection. We aim to clarify the mechanisms of CMV-induced pathogenesis and to find novel diagnostic markers and therapeutic strategies.

Infectious diseases remain the most common illness in childhood, especially for those with an immunodeficiency, underlying disorders, and those who have undergone surgery. We aim to develop novel diagnostic methods for a variety of pathogens that have direct impact on patient care and will also be exploited to understand the pathogenesis of infectious diseases, as well as to evaluate efficacy of therapeutics.

Current research projects

  1. Development of prevention strategies for allergic diseases
  2. Comprehensive analysis of immunological and allergic diseases using ‘omics’ technology
  3. Diagnosis and early treatment of KD patients at risk of developing coronary artery aneurysms
  4. Investigation of genetic and environmental factors associated with KD
  5. Exploration of mechanistic insights into immune tolerance induction and maintenance
  6. Studies of CMV-induced pathogenesis and development of novel diagnostic and therapeutic strategies for congenital CMV infection
  7. Diagnosis and therapy of severe pediatric infectious diseases

Members

Leaders

Researchers

  • Maiko Sugie
  • Keisuke Orimo
  • Motohiro Kuriyama
  • Sayuri Sakuragi

Research Collaborators

  • Shigeyoshi Fujiwara
  • Mariko Hara
  • Ayako Yamada
  • Takashi Inoue
  • Kyoko Saito

Graduate Students

  • Kodai Yajima
  • Ryo Matsuoka
  • Shokei Murakami
  • Hiroki Sugiyama
  • Naoko Nagano
  • Yukihiko Shibuya

Undergraduates

  • Yurika Ando

Assistant Researchers

  • Chika Shirakawa (Clinical Technologists)
  • Masako Fujiwara
  • Motomi Takami (Clinical Technologists)

Assistants

  • Tomoko Yoshikawa
  • Chihiro Usami

Bibliography

2018

  1. Emi-Sugie M, Toyama S, Matsuda A, Saito H, Matsumoto K. IL-33 induces functional CCR7 expression in human mast cells. J Allergy Clin Immunol. 2018;142:1341-1344
  2. Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H. Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? J Allergy Clin Immunol. 2018;141:1997-2001
  3. Tamari M, Orimo K, Motomura K, Arae K, Matsuda A, Nakae S, Saito H, Morita H, Matsumoto K. The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice. Allergol Int. 2018;67:680-387
  4. Arae K, Morita H, Unno H, Motomura K, Toyama S, Okada N, Ohno T, Tamari M, Orimo K, Mishima Y, Suto H, Okumura K, Sudo K, Miyazawa H, Taguchi H, Saito H, Matsumoto K, Nakae S. Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1b production by DCs. Sci Rep. 2018;8:11721
  5. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishizuka K, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y. the Japan Environment and Children's Study (JECS) Group. Small for gestational age infants were associated with maternal allergic features in the JECS birth cohort. Allergy. 2018 in press
  6. Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh J, Michikawa M, Niida S. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models. PLoS One. 2018;13:e0196929
  7. Yamamoto-Hanada K, Ishitsuka K, Pak K, Saito M, Ayabe T, Mezawa H, Konishi M, Yand L, Matsumoto K, Saito H, Ohya Y. Japan Environment and Children's Study (JECS) Group. Allergy and mental health among pregnant women in the Japan Environment and Children's Study. J Allergy Clin Immunol in Practice. 2018 in press.
  8. Matsumoto Y, Yokoi H, Kimura T, Matsumoto Y, Kawada M, Arae K, Nakae S, Ikeda T, Matsumoto K, Sakurai H, Saito K. Gastrin-releasing peptide (GRP) is involved in the establishment of allergic rhinitis in mice. Laryngoscope. 2018 in press.
  9. Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S. IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 2018;8:6639
  10. Dermenais F, Margaritte-Jeannin P, Bames KC, Matsumoto K et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50:42-52
  11. Sugita K, Steer CA, Martinez-Gonzalez I, Altunbulakli C, Morita H, Castro-Giner F, Kubo T, Wawrzyniak P, Rückert B, Sudo K, Nakae S, Matsumoto K, O’Mahony L, Akdis M, Takei F, Akdis CA. Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients. J Allergy Clin Immunol. 2018;141:300-310.
  12. Suto H, Nambu A, Morita H, Yamaguchi S, Numata T, Yoshizaki T, Shimura E, Arae K, Asada Y, Motomura K, Kaneko M, Abe T, Matsuda A, Iwakura Y, Okumura K, Saito H, Matsumoto K, Sudo K, Nakae S. IL-25 enhances Th17 cell-mediated contact dermatitis by promoting IL-1b production by dermal dendritic cells. J Allergy Clin Immunol. 2018;142:1500-1509
  13. Yamaoka M, Akiyama M, Ohyama W, Tachimoto H, Matsumoto K. Acute lymphoblastic leukemia with hypereosinophilia in a 3-year-old boy. Pediatr Int. 2018;60:88-90

2017

  1. Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salome B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclement C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavillio D, Curti A, Derre L, Jandus C. Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis. Nat Commun. 2017;8:593.
  2. Kortekaas Krohn I, Shikhagaie MM, Golebski K, Bernink JHJ, Breynaert C, Creyns B, Diamant Z, Fokkens WJ, Gevaert P, Hellings P, Hendriks RW, Klimek L, Mjösberg J, Morita H, Ogg G, O’Mahony L, Schwarze J, Seys SF, Shamji MH, Bal SM. Emerging roles of innate lymphoid cells in inflammatory diseases: clinical implications. Allergy. 2017 in press.
  3. Morita H, Suzuki H, Orihara K, Motomura K, Matsuda A, Ohya Y, Saito H, Nomura I, Matsumoto K. Food protein-induced enterocolitis syndromes with and without bloody stool have distinct clinicopathological features. J Allergy Clin Immunol. 2017;140:1718-1721.
  4. Yamamoto-Hanada K, Yang L, Ishitsuka K, Ayabe T, Mezawa H, Konichi M, Shoda T, Matsumoto K, Saito H, Ohya Y. Allergy characteristics of Japanese parents in the Japan Environment and Children's study: a nationwide birth cohort study. World Allergy Organ J. 2017;10:24.
  5. Nakamura S, Kimura Y, Mori D, Imada T, Izuta Y, Shibuya M, Sakaguchi H, Oonishi E, Okada N, Matsumoto K, Tsubota K. Restoration of tear secretion in a murine dry eye model by oral administration of palmitoleic acid. Nutrients. 2017;9:E364.
  6. Shinohara M, Matsumoto K, Fetal tobacco smoke exposure in the third trimester of pregnancy is associated with atopic eczema/dermatitis syndrome in infancy. Pediatr Allergy Immunol Pulmonol. 2017;30:155-162.
  7. Mitsui M, Shoda T, Natsume O, Nomura I, Narita M, Fukuda A, Sakamoto S, Kasahara M, Ohya Y. Factors associated with development of food allergy in young children after liver transplantation: A retrospective analysis of 10 years experience. J Allergy Clin Immunol Pract. 2017;5:1698-1706.
  8. Motomura K, Okada N, Morita H, Hara M, Tamari M, Orimo K, Matsuda G, Imadome KI, Matsuda A, Nagamatsu T, Fujieda M, Sago H, Saito H, Matsumoto K. A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro. PLoS One. 2017;12:e0177994.
  9. Sato M, Shoda T, Shimizu H, Orihara K, Futamura K, Matsuda A, Yamada Y, Irie R, Yoshioka T, Shimizu T, Ohya Y, Nomura I, Matsumoto K, Arai K. Gene expression patterns in distinct endoscopic findings for eosinophilic gastritis in children. J Allergy Clin Immunol Pract. 2017;5:1639-1649.
  10. Kimura N, Futamura K, Arakawa M, Okada N, Emrich F, Okamura H, Sato T, Shudo Y, Koyano TK, Yamaguchi A, Adachi H, Matsuda A, Kawahito K, Matsumoto K, Fischbein MP. Gene expression profiling of acute type A aortic dissection combined with in vitro assessment. Eur J Cardiothorac Surg. 2017;52:810-817.
  11. Toyama S, Okada N, Matsuda A, Morita H, Saito H, Fujisawa T, Nakae S, Karasuyama H, MatsumotoK. Human eosinophils constitutively express a unique serine protease, PRSS33. Allergol Int. 2017;66:463-471.
  12. Morita H, Nakae S, Saito H, Matsumoto K. IL-33 in clinical practice: size matters? J Allergy Clin Immunol. 2017;140:381-383.
  13. Shoda T, Matsuda A, Nomura I, Okada N, Orihara K, Mikami H, Ishimura N, Ishihara S, Matsumoto K, Kinoshita Y.: Eosinophilic esophagitis vs proton pump inhibitor-responsive esophageal eosinophilia: transcriptome analysis. J Allergy Clin Immunol. 2017;139:2010-2013.
  14. Shoda T, Futamura M, Yang L, Yamamoto-Hanada K, Narita M, Saito H, Ohya Y. Timing of eczema onset and risk of food allergy at 3 years of age: Ahospital-based prospective birth cohort study., J Dermatol Sci. 2017;86:90-96.
  15. Li S, Morita H, Rückert B, Boonpiyathad T, Neumann A, Akdis CA. Type 3 innate lymphoid cells induce proliferation of CD94+ natural killer cells. J Allergy Clin Immunol. 2017;140:1156-1159.
  16. Kawakami Y, Ando T, Lee JR, Kim G, Kawakami Y, Nakasaki T, Nakasaki M, Matsumoto K, Choi YS, Kawakami T. Defective NK cell activity in a mouse model of eczema herpeticum. J Allergy Clin Immunol. 2017;139:997-1006.
  17. Ogasawara T, Hatano M, Satake H, Ikari J, Taniguchi T, Tsuruoka N, Takano H, Fujimura L, Sakamoto A, Hirata H, Sugiyama K, Fukushima Y, Nakae S, Matsumoto K, Saito H, Fukuda T, Kurasawa K, Tatsumi K, Tokuhisa T, Arima M.: Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory TH2, Cells. Proc Natl Acad Sci USA. 2017;114:E741-E750.
  18. Sasaki M, Ebihara Y, Okamura K, Nakabayashi K, Igarashi A, Matsumoto K, Hata K, Kobayashi Y, Maehara K. Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses. PLoS One. 2017;12:e0171431.
  19. Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov K, Boldin M, Asahara H. Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proc Natl Acad Sci USA. 2017;114:3927-3932.
  20. Nowak-Wegrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Whitehorn TB, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Murano A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M. International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Food Commitee, American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol. 2017;139:1111-1126.
  21. Ando T, Kashiwakura J, Itoh-Nagato N, Yamashita H, Baba M, Kawakami Y, Tsai SH, Inagaki N, Takeda K, Iwata T, Shimojo N, Fujisawa T, Nagao M, Matsumoto K, Kawakami Y, Kawakami T. Histamine-releasing factor enhances food allergy. J Clin Invest. 2017;127:4541-4553.
  22. Ishihara S, Shoda T, Ishimura N, Ohta S, Ono J, Azuma Y, Okimoto E, Izuhara K, Nomura I, Matsumoto K, Kinoshita Y. Serum biomarkers for the diagnosis of eosinophilic esophagitis and eosinophilic gastroenteritis. Intern Med. 2017;56:2819-2825.

2016

  1. Takeda T, Unno H, Morita H, Futamura K, Emi-Sugie M, Arae K, Shoda T, Okada N, Igarashi A, Inoue E, Kitazawa H, Nakae S, Saito H, Matsumoto K, Matsuda A. Platelets constitutively express interleukin-33 protein and modulate eosinophilic airway inflammation. J Allergy Clin Immunol. 2016;138:1395-1403.
  2. Shoda T, Matsuda A, Arai K, Shimizu H, Morita H, Orihara K, Okada N, Narita M, Ohya Y, Saito H, Matsumoto K, Nomura I. Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels. J Allergy Clin Immunol. 2016;138:299-303.
  3. Horimukai K, Morita K, Narita M, Kondo M , Kabashima S, Inoue E, Sasaki T, Niizeki H, Saito H, Matsumoto K, Ohya Y. Transepidermal water loss measurement during infancy can predict the subsequent development of atopic dermatitis. Allergol Int. 2016;65:103-8.
  4. Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K. The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. J Allergy Clin Immunol. 2016;138:459-67.
  5. Fukuie T, Hirakawa S, Narita M, Nomura I, Matsumoto K, Tokura Y, Ohya Y. Potential preventive effects of proactive therapy on sensitisation in moderate to severe childhood atopic dermatitis: a randomised, investigator-blinded, controlled study. J Dermatol. 2016;43:1283-92.
  6. Morita H, Saito H, Matsumoto K, Nakae S. Regulatory roles of mast cells in immune responses. Semin Immunopathol. 2016;38:623-9.
  7. Morita H, Moro K, Koyasu S.: Innate lymphoid cells in allergic and nonallergic inflammation., J Allergy Clin Immunol . 2016;138:1253-64.
  8. Shoda T, Futamura K, Orihara K, Emi-Sugie M, Saito H, Matsumoto K, Matsuda A. Recent advances in the roles of vascular endothelial cells in allergic inflammation. Allergol Int. 2016;65:21-9.
  9. Orihara K, Saito H. Controlling the peripheral clock might be a new treatment strategy in allergy and immunology. J Allergy Clin Immunol. 2016;137:1236-7.
  10. Ozeki N, Sekiya I, Muneta T, Koga H, Nakagawa Y, Mizuno M, Tsuji K, Mabuchi Y, Akazawa C, Kobayashi E, Futamura K, Matsumoto K, Saito T. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats. Osteoarthritis Cartilage. 2016;24:1061-70.
  11. Shibui A, Takamori A, Tolba MEM, Nambu A, Shimura E, Yamaguchi S, Sanjoba C, Suto H, Sudo K, Okumura K, Sugano S, Morita H, Saito H, Matsumoto M, Nakae S. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Biochemis Biophysics Rep. 2016;1:191-5.
  12. Tsumura H, Ito M, Takami M, Arai M, Li X-K, Hamatani T, Igarashi A, Takada S, Miyado K, Umezawa A, Ito Y. Conditional deletion of CD98hc inhibits osteoclast development. Biochem Biophys Rep. 2016;1:203-10.
  13. Nakanishi W, Hiraishi Y, Yamaguchi S, Takamori A, Morita H, Matsumoto M, Saito H, Sudo K, Yamasoba T, Nakae S. TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice. Biochemis Biophysics Rep. 2016;7: 119-23.
  14. Hiraishi Y, Nambu A, Shibui A , Nakanishi W, Yamaguchi S, Morita H, Iikura M, McKenzie ANJ, Matsumoto K, Sudo K, Yamasoba T, Nagase T, Nakae S. TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens . Allergol Int. 2016;65:459-65.
  15. Saito K, Arai E, Maekawa K, Ishikawa M, Fujimoto H, Taguchi R, Matsumoto K, Kanai Y, Saito Y. Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma. Sci Rep. 2016;6:28932.
  16. Kayano M, Higaki S, Satoh J. Matsumoto K, Matsubara E, Takikawa O, Niida S.: Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis , Biomarker Research. 2016:4;22.
  17. Matsumoto K, Izuhara K.: Anaphylaxis-two stories not covered by the current guidelines. Allergol Int. 2016;65:1-2.
  18. Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Frestl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O’Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA., Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2016;138:984-1010.
  19. Liao H, Sato H, Chiba R, Kawai T, Nakabayashi K, Hata K, Akutsu H, Fujiwara S, Nakamura H. Human cytomegalovirus downregulates SLITRK6 expression through IE2., J Neurovirol. 2016;23:79-86.

2015

  1. Morita H, Nambu A, Oboki K, Ohno T, Matsuda A, Arae K, Unno H, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, Okumura K, Azuma M, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S. An interleukin-33-mast cell-interleukin-2 axis suppresses papain-induced allergic airway inflammation by promoting regulatory T cell numbers. Immunity. 2015;43:175-86.
  2. Morita H, Arae K, Unno H, Toyama S, Motomura K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Saito H, Matsumoto K, Nakae S. IL-25 and IL-33 contribute to development of eosinophilic airway inflammation in epicutaneously antigen-sensitized mice. PLoS One. 2015;10:e0134226.
  3. Shoda T, Morita H, Nomura I, Ishimura N, Ishihara S, Matsuda A, Matsumoto K, Kinoshita Y. Comparison of gene expression profiles in eosinophilic esophagitis (EoE) between Japan and Western countries. Allergol Int. 2015;64:260-5.
  4. Horimukai K, Hayashi K, Tsumura Y, Nomura I, Narita M, Ohya Y, Saito H, Matsumoto K. Total serum IgE level influences oral food challenge tests for IgE-mediated food allergies. Allergy. 2015;70:334-7.
  5. Matsumoto K. Preface to the Proceedings of the Workshop on Eosinophils in Allergy and Related Diseases 2014. Allergol Int. 2015;64 Suppl:S1-2.
  6. Kamemura1 N, Takashima M, Morita H, Matsumoto K, Saito H, Kido H..Measurement of allergen-specific secretory IgA in stool of neonates, infants and toddlers by protection against degradation of immunoglobulins and allergens. The Journal of Medical Investigation. 2015;62:137-44.
  7. Wakiguchi H, Hasegawa H, Kaneyasu H, Kajimoto M, Fujimoto Y, Hirano R, Katsura R, Matsumoto K, Ichiyama T, Ohga S. Long-lasting non-IgE-mediated gastrointestinal cow’s milk allergy in infants with Down syndrome. Pediatr Allergy Immunol. 2015;26:821-3.
  8. Goubard A, Loiez C, Abe J, Fichel C, Herwegh S, Faveeuw C, Porte R, Cayet D, Sebbane F, Penet S, Foligné B, Desreumaux P, Saito H, Sirard JC, Simonet M, Carnoy C. Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells. Infect Immun. 2015;83:2053-64.
  9. Anaparti V, Ilarraza R, Orihara K, Stelmack GL, Ojo OO, Mahood TH, Unruh H, Halayko AJ, Moqbel R. NMDA receptors mediate contractile responses in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015;308:L1253-64.
  10. Taniguchi R, Koyano S, Suzutani T, Goishi K, Ito Y, Morioka I, Nakamura H, Yamada H, Oka A, Inoue N. A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease. Infection. 2015;43:353-9.
  11. Gocho Y, Kiyokawa N, Ichikawa H, Nakabayashi K, Osumi T, Ishibashi T, Ueno H, Terada K, Oboki K, Sakamoto H, Shioda Y, Imai M, Noguchi Y, Arakawa Y, Kojima Y, Toyama D, Hata K, Yoshida T, Matsumoto K, Kato M, Fukushima T, Koh K, Manabe A, Ohara A. A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia. Leukemia. 2015;29:2445-8.
  12. Katoh-Fukui Y, Igarashi M, Nagasaki K, Horikawa R, Nagai T, Tsuchiya T, Suzuki E, Miyado M, Hata K, Nakabayashi K, Hayashi K, Matsubara Y, Baba T, Morohashi K, Igarashi A, Ogata T, Takada S, and Fukami M. Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of SOX9. Mol Genet Genomic Med. 2015;3:550-7.
  13. Akiyama M, Yamaoka M, Mikami-Terao Y, Yokoi K, Inoue T, Hiramatsu T, Ashizuka S, Yoshizawa J, Katagi H, Ikegami M, Ida H, Nakazawa A, Okita H, Matsumoto K. Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production. J Pediatr Hematol Oncol. 2015;37:554-9.
  14. Nunomura S, Okayama Y, Matsumoto K, Hashimoto N, Endo-Umeda K, Terui T, Makishima M, Ra C. Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells. Allergol Int. 2015;64 Suppl:S11-7.
  15. Tanabe K, Kitagawa E, Wada M, Haraguchi A, Orihara K, Tahara Y, Nakao A, Shibata S. Antigen exposure in the late light period induces severe symptoms of food allergy in an OVA-allergic mouse model. Sci Rep. 2015;5:14424.
  16. Yano M, Imamura T, Asai D, Kiyokawa N, Nakabayashi K, Matsumoto K, Deguchi T, Hashii Y, Honda YK, Hasegawa D, Sasahara Y, Ishii M, Kosaka Y, Kato K, Shima M, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K, Ichikawa H, Sato A. Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. Br J Haematol. 2015;171:813-7.
  17. Arai E, Gotoh M, Tian Y, Sakamoto H, Ono M, Matsuda A, Takahashi Y, Miyata S, Totsuka H, Chiku S, Komiyama M, Fujimoto H, Matsumoto K, Yamada T, Yoshida T, Kanai Y. Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. Int J Cancer. 2015;137:2589-606.
  18. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T. Global DNA hypomethylation coupled to cellular transformation and metastatic ability. FEBS Lett. 2015;589:4053-60.
  19. Horimukai K, Hayashi K, Tsumura Y, Nomura I, Narita M, Ohya Y, Saito H, Matsumoto K. Total serum IgE level influences oral food challenge tests for IgE-mediated food allergies. Allergy. 2015;70:334-7.

2014

  1. Unno H, Futamura K, Morita H, Kojima R, Arae K, Nakae S, Ida H, Saito H, Matsumoto K, Matsuda A. Silica and double-stranded RNA synergistically induce bronchial epithelial apoptosis and airway inflammation. Am J Respir Cell Mol Biol. 2014;31:344-53.
  2. Shoda T, Futamura K, Kobayashi F, Saito H, Matsumoto K, Matsuda A. Expression of thymus and activation-regulated chemokine (TARC) by human dermal cells, but not epidermal keratinocytes. J Dermatol Sci. 2014;76:90-5.
  3. Kojima R, Ohno T, Iikura M, Niki T, Hirashima M, Iwaya K, Tsuda H, Nonoyama S, Matsuda A, Saito H, Matsumoto K, Nakae S. Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line. PLoS One. 2014;9:e86106.
  4. Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014;134:824-30.
  5. Watanabe-Takano H, Takano K, Sakamoto A, Matsumoto K, Tokuhisa T, Endo T, Hatano M. DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation. Proc Natl Acad Sci USA. 2014;111:E2291-300.
  6. Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S. Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock. Biochem Biophys Res Commun. 2014;453:1-6.
  7. Saito M, Shiraishi K, Matsumoto K, Schetter AJ, Ogata-Kawata H, Tsuchiya N, Kunitoh H, Nokihara H, Watanabe S, Tsuta K, Kumamoto K, Takenoshita S, Yokota J, Harris CC, Kohno T. A three-microRNA signature predicts responses to platinum-based doublet chemotherapy in patients with lung adenocarcinoma. Clin Cancer Res. 2014;20:4784-93.
  8. Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N. NEK9-dependent proliferation of cancer cells lacking functional p53. Sci Rep. 2014;4:6111.
  9. Kobayashi K, Mitsui K, Ichikawa H, Nakabayashi K, Matsuoka M, Kojima Y, Takahashi H, Iijima K, Ootsubo K, Oboki K, Okita H, Yasuda K, Sakamoto H, Hata K, Yoshida T, Matsumoto K, Kiyokawa N, Ohara A. ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. Bri J Haematol. 2014;165:836-41.
  10. Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FceRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol. 2014;192:3936-46.
  11. Ando T, Xiao W, Gao P, Namiranian S, Matsumoto K, Tomimori Y, Hong H, Yamashita H, Kimura M, Kashiwakura J, Hata TR, Izuhara K, Gurish MF, Roers A, Rafaels NM, Barnes KC, Jamora C, Kawakami Y, Kawakami T. Critical role for mast cell stat5 activity in skin inflammation. Cell Rep. 2014;6:366-76.
  12. Fujimaru T, Ito S, Masuda H, Oana S, Kamei K, Ishiguro A, Kato H, Abe J. Decreased levels of inflammatory cytokines in immunoglobulin-resistant Kawasaki disease after plasma exchange. Cytokine. 2014;70(2):156-160.
  13. Masuzawa A, Kiyotani C, Osumi T, Shioda Y, Iijima K, Tomita O, Nakabayashi K, Oboki K, Yasuda K, Sakamoto H, Ichikawa H, Hata K, Yoshida T, Matsumoto K, Kiyokawa N, Mori T. Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript. Eur J Haematol. 2014;92(3):263-7.