国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

Department of Social Medicine

Our department takes an interdisciplinary epidemiological approach to examine the role of the fetal and early life environment in influencing health status in childhood and adolescence/adulthood. We aim to further our understanding of the determinants of disease and suffering in children and their families and use this knowledge to advocate for an environment that is optimal for childbearing and childrearing. 


The collective expertise of this department’s permanent staff, represented by a broad range of ongoing research, includes epidemiology, biostatistics, sociology, molecular genetics, mental health, nutrition, pediatrics, perinatal medicine, and childhood cognitive, behavioral, and social development. We utilize various methodological approaches, ranging from linkage of large national demographic and clinical databases to field-based work that involves population recruitment, biological sample collection and qualitative research strategies.


In our department, we believe epidemiological research thrives through collaboration which is essential for a continuous pursuit towards enhancing the quality and representativeness of our studies. 


Our current research (as of June, 2017) addresses the following themes:


Research Themes


Childhood Hematological Cancers


  • Genetic susceptibility to childhood acute lymphoblastic leukemia

In collaboration with a large network of Tokyo Children’s Cancer Study Group hospitals and clinicians, DNA from saliva has been collected from childhood ALL patients and underwent whole genome microarray SNP genotyping.  Case-control genome-wide association study (GWAS) analyses are being conducted to identify genetic variants associated childhood ALL risk in Japanese.

 

  •  Epidemiological Study of Hematological Cancers in Children (EPI-HCC)

This case-control study aims to evaluate the role of pregnancy-related factors, fetal environment, and early postnatal exposures in the risk of childhood leukemia and lymphoma. DNA samples are also collected from children and their parents to examine the effect of gene-environment interactions, as well as possible maternal genetic effects on the risk of leukemia in the child.

 

  • The effect of inherited genetic variation on treatment-related outcomes in childhood ALL patients

Various follow-up clinical data on prognostic indictors and major treatment-related clinical manifestations have been collected and is being linked to the patients’ data on inherited genetic variation. Identification of genetic variants associated with these clinical outcomes can contribute to understanding biological mechanisms and personalized genomic medicine strategies.

 

NCCHD Maternal-Child Cohort


As members of the NCCHD Maternal-Child Cohort research group, we are pursuing projects to understand how nutritional factors, eating habits and behavior during pregnancy and childhood influence maternal and child health. Outcomes currently under examination include, growth, cognitive development and metabolic functions. As a broader object of this cohort, we expect to pursue additional themes related to the “developmental origins of health and disease” concept.

 

Effect of the Social Environment in Maternal and Child Health


  • A collaborative study with the local government on the effect of socioeconomic disadvantage on child health and development.

Working with the city of Adachi and the Tokyo Medical and Dental University, we are examining the effects of socio-economic adversities on child health and development among students in public elementary and middle schools. We also utilize the collected data to evaluate policies and programs aimed at supporting socio-economically disadvantaged families and children.


  • Motivational interviewing techniques as an intervention to prevent birth defects and child maltreatment.

We are conducting intervention studies with local governments to promote the normal development of infants and to evaluate infant abuse preventive measures. In particular, we are examining the effect of motivational interviewing strategies in those who show reluctance to receiving social support.

 

  • Intervention and Observational Studies Related to Childhood Obesity

Working with the city of Setagaya, we are conducting a randomized controlled trial evaluating the effect of a family intervention program with focus on the paternal role in childhood obesity. In addition, we are pursuing data analysis related to preventive screening of childhood diseases based on data taken at the children’s health check-up visits.

 

Longitudinal Population Health Survey Research in Maternal and Child Health


  • Government-sponsored Longitudinal Survey of Newborns in the 21st Century

Utilizing data from these national population health surveys, we evaluate issues surrounding Japanese children and families to help us understand what are the most beneficial childbearing and childrearing environment. Some topics of interest include benefits of breastfeeding and risks of unintentional injuries , early childhood dental caries, and poor adjustment to school environment.

 

  • Government-sponsored Healthy Parents and Children 21 National Survey

In collaboration with Yamanashi University and The University of Tokyo, we are utilizing existing survey data to examine the effect of municipal-sponsored programs in reducing childhood unintentional injury and parenting difficulties. The intention of these programs is to help promote normal development of the infants and prevent infant abuse.

 

  • Government-sponsored Japan Environment and Children’s Study

In collaboration with Kyushu University, we are utilizing existing survey data from this national birth cohort to examine the long term effects of nutritional and behavioral exposures during pregnancy on the child’s growth, development, and metabolic and endocrinological functions.

 

Clinical Epidemiology Studies of Pediatric Diseases


In collaboration with The University of Tokyo, we are utilizing data from the Nation-wide Diagnosis Procedure Database, to assess treatment outcomes and cost effectiveness of various drugs, procedures and treatment regimen for pediatric diseases. Examples of recent analyses undertaken include the effect of obesity on acute asthma exacerbation as well as recent treatment trends and cost-effective analyses between different treatment regimens in common pediatric disorders, including pediatric anaphylaxis, Kawasaki Disease, immune thrombocytopenia, and influenza-related respiratory disorder.


“Big data” Linkage Projects in Maternal and Child Health


We utilize data-linkage techniques to build comprehensive datasets, promote collaborative utilization of these databases, and obtain high-quality results that would not have been possible from analyzing them separately. In addition, these linkage techniques can assist in validating coverage and accuracy of individual databases, and contribute to future research infrastructure. Several of these projects are being pursued with international collaborators to compare results between countries and/or conduct pooled analyses.

Databases currently in use include nation-wide registries run by the Japan Society of Obstetrics and Gynecology, Japan Society of Pediatrics, Japan Society for Neonatal Health and Development, and maternal and child health related registries and surveys conducted by the Ministry of Health, Labour and Welfare.


Members

Leadership 

Kevin Urayama 

Tsuguhiko Kato (Chief, Division of Behavioral Science)

Naho Morisaki   (Chief, Division of Life Course Epidemiology)


Researchers 

Makiko Sampei

Hisako Tanaka 

Mayumi Hangai

Aurelie piedvache


Research Assistants

Hiromi Nakano

Yoko Ayukawa

Shinobu Kobayashi

Sanae Kobayashi



Research Collaborators

Kohei Ogawa

Tomo Suzuki

Yukiko Honda

Yukako Tani

Airi Amemiya

Minatsu Kobayashi

Yuko Kachi

Yusuke Okubo

Emi Adachi

Emiko Ando

Shohei Harada

Atsushi Ito

Takeo Fujiwara

Kayo Onishi

Michiko Sekiguchi


Publication

  1. Kobayashi M, Jwa SC, Ogawa K, Morisaki N, Fujiwara T: Validity of food frequency questionnaires to estimate long-chain polyunsaturated fatty acid intake among Japanese women in early and late pregnancy. Journal of Epidemiology 2017 Jan; 27(1): 30-35
  2. Okubo Y, Nochioka K, Sakakibara H, Marcia T, Robert P Sundel: National survey of pediatric hospitalizations due to Kawasaki disease and coronary artery aneurysms in the USA. Clinical Rheumatology 2017 Feb;36(2):413-419.
  3. Chibueze C, Tirado V, Silva Lopes K, Yo T, Balogun OO, Swa T, Dagvadorj A, Nagata C, Morisaki N, Ota E, Mori R, Oladapo OT, Menedez C. Zika virus infection in pregnancy: a systematic review of disease course and complications. Reproductive Health 2017 Feb;14(1):28. doi: 10.1186/s12978-017-0285-6.
  4. Kato T, Yorifuji T, Yamakawa M, Inoue S, Doi H, Eboshida A, Kawachi I (2017). Associations of Maternal Age with Child Health: A Japanese Longitudinal Study. PLoS One 2017 Feb 24;12(2):e0172544. D
  5. Hines D, Modi N, Lee SK, Isayama T, Sjörs G, Gagliardie L, Lehtonenf L, Ventog M, Kusuda S, Bassleri D, Mori R, Reichman B, Håkansson S, Darlow B, Adams M, Rusconi M, Feliciano LS, Lui K, Morisaki N, Musrap N, Shah PS: Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus. Acta Paediatrica 2017 Mar;106(3):366-374. ※    Editorial あり: Jobe AH, Bancalari EH. Controversies about the definition of bronchopulmonary dysplasia at 50 years. Acta Pediatrica 2017 Mar;106(3):692-693
  6. Okubo Y, Nochioka K, Testa M: Nationwide Survey of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children in the United States. Pediatric Dermatology 2017 Mar; 34: 206-208.
  7. Delnord M, Hindori-Mohangoo A, Smith L, Szamotulska K, Richards J, Deb-Rinker P, Rouleau J, Velebil P, Sile I, Sakkeus L, Gissler M, Morisaki N, Dolan S, Kramer MR, Kramer MS, Zeitlin J. Variations in very preterm births rates in 30 high-income countries: are valid international comparisons possible using routine data? BJOG: international journal of obstetrics and gynaecology 2017 Apr;124(5):785-794. Letter to the Editorあり: Filipovic-Grcic B, Rodin U. Croatian experience supporting inclusion of routine very preterm birth data for valid comparison. BJOG 2017 Apr;124(5) 
  8. Sasaki H, Kakee N, Morisaki N, Mori R, Ravens-Sieberer U, Bullinger M. Assessing health related quality of life in young Japanese children with chronic conditions: Validation of the DISABKIDS Smiley measure. BMC Pediatrics 2017 Apr 5; 17(1):100
  9. Morisaki N, Kawachi I, Oken E, Fujiwara T. Social and anthropometric factors explaining racial/ethnical differences in birth weight in the United States. Scientific Reports. 2017 Apr 21;7:46657. doi: 10.1038/srep46657. 
  10. Ogawa K, Kobayashi M, Jwa SC, Morisaki N, Fujiwara T. Validation of a food frequency questionnaire for Japanese pregnant women with and without nausea and vomiting in early pregnancy. J Epidemiology 2017 May;27(5):201-208. 
  11. Ogawa K, Morisaki N, Sato S, Saito S, Fujiwara T, Sago H. Association of shorter height with increased risk of Ischaemic Placental Disease. Paediatric and Perinatal Epidemiology 2017 (author 1 & 2 contributed equally) 2017 May;31(3):198-205.※    Editorialあり: Downes KL, Ananth CV. Short Maternal Stature and Increased Risk of Ischaemic Placental Disease: Is the Association Driven by Unmeasured Confounding? Paediatric and Perinatal Epidemiology 2017 May;31(3):206-208.
  12. Morisaki N, Zhang X, Ganchimeg T, Vogel J, Zeitlen J, Souza JP, Cecatti JG, Torloni MR, Ota E, Mori R, Tough S, Dolan SM, Kramer MS. Provider-Initiated Delivery and Perinatal Outcomes: A Secondary Analysis of the WHO Multi-Country Survey on Maternal and Newborn Health. BMJ Global Health 2017 May 18. doi: 10.1136/bmjgh-2016-000204.
  13. Chibueze CE, Parsons AJ, Silva Lopes K, Yo T, Swa T, Nagata C, Horita N, Morisaki N, Balogun OO, Dagvadorj A, Ota E, Mori R, Oladapo OT. Accuracy of ultrasound scanning relative to reference tests for prenatal diagnosis of microcephaly in the context of Zika virus infection: a systematic review of diagnostic test accuracy. Scientific Reports 2017 May 23;7:2310. doi: 10.1038/s41598-017-01991-y.
  14. Inoue S, Yorifuji T, Hiroo N, Kato T, Murakoshi T, Doi H, and Subramanian SV: Impact of maternal and paternal smoking on birth outcomes. Journal of Public Health 2016 May 24. pii: fdw050. [Epub ahead of print] 
  15. Kato T, Fujiwara T, Kawachi I: Associations between mothers’ active engagement with infants at 6 months and children’s adjustment to school life at ages 5.5 and 11 years, Child.  Care, Health and Development. 2016 Dec 19. doi: 10.1111/cch.12432. [Epub ahead of print] 
  16. Morisaki N, Ganchimeg T, Vogel J, Zeitlen J, Cecatti JG, Souza JP, Castro CP, Torloni MR, Ota E, Mori R, Dolan SM, Tough S, Mittal S, Bataglia V, Yadamsuren B, Kramer MS. Impact of stillbirths on international comparisons of preterm birth rates: A secondary analysis of the WHO multi-country survey of Maternal and Newborn Health. BJOG: international journal of obstetrics and gynaecology (author 1 and 2 contributed equally) BJOG. 2017 Feb 20. doi: 10.1111/1471-0528.14548. [Epub ahead of print]※    Editorial あり:Goldenberg RL, McClure EM. Importance of Including Stillbirth in Measures of Preterm Birth.
  17. Okubo Y, Nochioka K, Testa M. Nationwide survey of pediatric acute osteomyelitis in the USA. Journal of Pediatric Orthopedics B. 2017 Feb 22. doi: 10.1097/BPB.0000000000000441. [Epub ahead of print]
  18. Darlow BA, Lui K, Kusuda S, Reichman B, Gagliardi L, Håkansson S, Bassler D, Modi N, Lee S, Lehtonen L, Vento M, Isayama T, Sjörs G, Helenius KK, Adams M, Rusconi F, Morisaki N, Shah PS. International variations and trends in the treatment for retinopathy of prematurity. British J Ophthalmology 2017 Mar 7. doi: 10.1136/bjophthalmol-2016-310041. [Epub ahead of print]
  19. Zhao Y, Zhang J, Zamora J, Vogel J, Souza J, Ganchmeg T, Ortiz-Panozo E, Hernandez B, Oladapo O, Torloni M, Morisaki N, Mori R, Pileggi C, Tuncalp O, Shen X, Betran APIncreases in caesarean section rates and perinatal outcomes in low- and middle-income countries: a hospital level analysis of two WHO surveys. Paediatric and Perinatal Epidemiology 2017 May 20. doi:10.1111/ppe.12363 [Epub ahead of print]
  20. Nagata C, Moriichi A, Morisaki N, Mori R. Japan's 115-year trend of inter-prefectural disparities in under-five mortality. Pediatrics International 2017 May 23. doi: 10.1111/ped.13304. [Epub ahead of print] 
  21. Morisaki N, Nagata C, Jwa SC, Sago H, Saito S, Oken E, Fujiwara T. Pre-pregnancy BMI-specific optimal gestational weight gain for women in Japan. J Epidemiology 2017, doi: 10.1016/j.je.2016.09.013  [Epub ahead of print]
  22. Morisaki N, Ogawa K, Urayama KY, Sago H, Sato S, Saito S. Preeclampsia mediates the association between shorter height and increased risk of preterm delivery. International Journal of Epidemiology 2017, doi: 10.1093/ije/dyx107 [Epub ahead of print]
  23. 森崎菜穂*, 永田知映, 左合治彦, 齋藤滋: 日本人にとっての適切な妊娠中体重増加量の算出. 産婦人科の実際 2017 4月号;66 (6) 522-526  日本産婦人科学会の周産期登録データベースから妊娠前BMI別の最適妊娠中体重増加量を産出し、現推奨はやせ妊婦には低すぎる可能性が高いことを示した。
  24. Okuzono S, Fujiwara T, Kato T, Kawachi I: Spanking and subsequent behavioral problems in toddlers: A propensity score-matched, prospective study in Japan.  Child Abuse & Neglect 24; 69: 62-71
  25. Aida J, Matsuyama Y, Tabuchi T, Komazaki Y, Tsuboya T, Kato T, Osaka K, Fujiwara T :Trajectory of social inequalities in the treatment of dental caries among preschool children in Japan. Journal of Community Dentistry & Oral Epidemiology.
  26. Okubo Y, Habda AThe impact of obesity on pediatric inpatients with urinary tract infections in the United StatesJ Peiatr Urol 2017pii: S1477-5131(17)30227-9
  27. Okubo Y, Handa A: National trend survey of hospitalized patients with febrile seizure in the United States. Seizure: European Journal of Epilepsy  Accepted at 20 Jun, 2017
  28. Okubo Y, Nochioka K, Matcia A Testa: Nationwide survey of pediatric septic arthritis in the United States. Journal of Orthopeedics  Accepted at 21 June, 2017
  29. Amemiya A, Fujiwara T, Murayama H, Tani Y, Kondo KAdverse Childhood Experiences and Higher-Level Functional Limitations Among Older Japanese People: Results From the JAGES StudyThe Journals of Gerontology  Series A 02 June 2017  虐待や親との離別な
  30. Maeda K, Hasegawa D, Urayama KY, Tsujimoto S, Azami Y, Ozawa M, Manabe A Risk factors for psychological and psychosomatic symptoms among children with malignancies. Journal of Paediatrics and Child Health  2017  In press.
  31. Hoshino E, Hayashi K, Suzuki M, Obatake M, Urayama KY, Nakano S, Taura Y, Nio M, Takahashi O An iPhone application using a novel stool color detection algorithm for biliary atresia screening. Pediatric Surgery International  2017  doi: 10.1007/s00383-017-4146-8.
  32. Huang M, Inukai T, Kagami K, Abe M, Shinohara T, Watanabe A, Somazu S, Oshiro H, Goi K, Goto H, Minegishi M, Iwamoto S, Urayama KY, Sugita K Splicing variant profiles and single nucleotide polymorphisms of the glucocorticoid receptor gene in relation to glucocorticoid-sensitivity of B-cell precursor acute lymphoblastic leukaemia. Hematological Oncology  2017  doi: 10.1002/hon.2471.
  33. Sudo T, Okada Y, Ozaki K, Urayama K, Kanai M, Kobayashi H, Gokyu M, Izumi Y, Tanaka T Mutations in NOD2 cause aggressive periodontitis. Journal of Dental Research  In Press 2017
  34. Richards JL*, Kramer MS, Deb-Rinker P, Rouleau J, Mortensen L, Gissler M, Morken NH, Skjærven R, Cnattingius S, Johansson S, Delnord M, Dolan SM, Morisaki N, Tough S, Zeitlin J, Kramer MR Temporal Trends in Late Preterm and Early Term Birth Rates in 6 High-Income Countries in North America and Europe and Association With Clinician-Initiated Obstetric Interventions. Obstetric Anesthesia Digest 2017 J  Jun; 37(2):68-69
  35. Zhao Y, Zhang J*, Zamora J, Vogel J, Souza J, Ganchmeg T, Ortiz-Panozo E, Hernandez B, Oladapo O, Torloni M, Morisaki N, Mori R, Pileggi C, Tuncalp O, Shen X, Betran APIncreases in Caesarean Delivery Rates and Change of Perinatal Outcomes in Low- and Middle-Income Countries: A Hospital-Level Analysis of Two WHO Surveys. Paediatric and Perinatal Epidemiology 2017 Jul;31(4):251-262Editorial: Althabe F, Belizán JM. Rising Trend in Non-Indicated Caesarean Deliveries: Can the Trend be Reversed? Paediatric and Perinatal Epidemiology 2017 Jul;31(4):263-266.
  36. Nagata C*, Moriichi A, Morisaki N, Mori R. J Inter-prefecture disparity in under-5 mortality: 115 year trend in Japan. Pediatrics International 2017 Jul;59(7):816-820.
  37. Morisaki N*, Ganchimeg T, Vogel J, Zeitlen J, Cecatti JG, Souza JP, Castro CP, Torloni MR, Ota E, Mori R, Dolan SM, Tough S, Mittal S, Bataglia V, Yadamsuren B, Kramer MS Impact of stillbirths on international comparisons of preterm birth rates: A secondary analysis of the WHO multi-country survey of Maternal and Newborn Health. BJOG: international journal of obstetrics and gynaecology (author 1 and 2 contributed equally) 2017 Aug;124(9):1346-1354 Editorial: Goldenberg RL, McClure EM. Importance of including stillbirth in measures of preterm birth. 2017 Aug;124(9):1355
  38. Morisaki N*, Urayama KY, Yoshii K, Subramanian SV, Yokoya S Ecological analysis of secular trends in low birth weight births and adult height in Japan. J Epidemiology and Community Health  2017 Aug 19. doi: 10.1136/jech-2017-209266. [Epub ahead of print]
  39. Morisaki N*, Isayama T, Samura O, Wada K, Kusuda S Socioeconomic inequity in survival for deliveries at 22-24 weeks of gestation. Archives Neonatal Fetal 2017 Aug 28. doi: 10.1136/archdischild-2017-312635. [Epub ahead of print] Editorial あり:Field D, Smith L. (in press)
  40. Okubo Y*, Michihata N, Morisaki N, Hangai M, Matsui H, Fushimi K, Yasunaga H Recent trends in practice patterns and comparisons between immunoglobulin and corticosteroid in pediatric immune thrombocytopenia. International Journal of Hematology 2017 Aug 28  doi: 10.1007/s12185-017-2322-1. [Epub ahead of print] 
  41. Yamaoka Y, Morisaki N*, Noguchi H, Takahashi H, Tamiya N Comprehensive assessment of risk factors of cause-specific infant deaths in Japan. Journal of Epidemiology (2017.7.4 in press)
  42. Helenius K*, Sjors G, Shah PS, Modi N, Reichman B, Morisaki N, Kusuda S, Lui K, Darlow B, Bassler D, Hakansson S, Adams M, Vento M, Rusconi F, Isayama T, Lehtonen L Survival in very preterm infants: an international comparison of 10 national neonatal networks. Pediatrics (2017.8.16 in press)
  43. Delnord M*, Mortensen L, Hindori-Mohangoo A, Blondel B, Gissler M, Kramer MR, Richards JL, Deb-Rinker P, Morisaki N, Nassar N, Nybo Andersen AM, Kramer MS, Zeitlin J. Can we apply a population approach to preterm birth prevention? An ecological study of preterm and early term births in 34 high-income countries. European Journal of Public Health (2017.8.24 in press)
  44. Okubo Y*, Michihata N, Yoshida K, Morisaki N, Matsui H, Fushimi K, Yasunaga H Effect of pediatric obesity on acute asthma exacerbation in Japan. Pediatric Allergy and Immunology. (2017.09.06 in press)
  45. Inoue S, Kato T, Yorifuji T: Self-rated school adjustment and absenteeism: An epidemiological study. Health Behavior & Policy Review  2017
  46. Okubo Y, Nochioka T, Testa MA: The impact of pediatric obesity on hospitalized children with lower respiratory tract infections in the United States. Clinical Respiratory Journal 2017 [Epub ahead of print]
  47. Morimoto N, Kasuga C, Tanaka A, Kamachi K, Ai M, Urayama KY, Tanaka A Association between dietary fiber to carbohydrate intake ratio and insulin resistance in Japanese adults without diabetes. British Journal of Nutrition 2017 In press
  48. Okubo Y, Michihata N, Morisaki N, Kinoshita N, Miyairi I, Urayama KY, Yasunaga H Recent patterns in antibiotic use for children with group A streptococcal infections. Journal of Global Antimicrobial Resistance 2017; In press
  49. Ogawa K, Urayama KY, Tanigaki S, Sago H, Sato S, Saito S, Morisaki N Association between very advanced maternal age and adverse pregnancy outcomes: a multicenter retrospective cohort study. BMC Pregnancy and Childbirth 2017;In press 
  50. Doi S, Fujiwara T, Ochi  M, Isumi A, Kato T ; Relationship between sleep habits and the mental health of 6 to 7-year-old children: Results from the A-CHILD study, Sleep Medicine. 2017; in press
  51. Morisaki N*, Nagata C, Jwa SC, Sago H, Saito S, Oken E, Fujiwara T. Pre-pregnancy BMI-specific optimal gestational weight gain for women in Japan. Journal of Epidemiology  2017 ;Oct 27(10):492-498.
  52. Darlow BA*, Lui K, Kusuda S, Reichman B, Gagliardi L, Håkansson S, Bassler D, Modi N, Lee S, Lehtonen L, Vento M, Isayama T, Sjörs G, Helenius KK, Adams M, Rusconi F, Morisaki N, Shah PS: International variations and trends in the treatment for retinopathy of prematurity. British Journal of Ophthalmology 2017; Oct101(10):1399-1404
  53. Morisaki N*, Urayama KY, Yoshii K, Subramanian SV, Yokoya S: Ecological analysis of secular trends in low birth weight births and adult height in Japan. J Epidemiology and Community Health 2017; Oct 71(10):1014-1018.
  54. Morisaki N*, Ogawa K, Urayama KY, Sago H, Sato S, Saito S: Preeclampsia mediates the association between shorter height and increased risk of preterm delivery. International Journal of Epidemiology 2017; Oct 1 46(5):1690-1698.
  55. Kobayashi M, Ogawa K, Morisaki N, Tani Y, Fujiwara T*: Dietary n-3 polyunsaturated fatty acids in late pregnancy and postpartum depression symptoms among Japanese women. Frontiers in Psychiatry  Public Mental Health 2017; Nov 23;8:241
  56. Helenius K*, Sjors G, Shah PS, Modi N, Reichman B, Morisaki N, Kusuda S, Lui K, Darlow B, Bassler D, Hakansson S, Adams M, Vento M, Rusconi F, Isayama T, Lehtonen L: Survival in very preterm infants: an international comparison of 10 national neonatal networks. Pediatrics 2017; Dec140(6) pii: e20171264
  57. Delnord M*, Mortensen L, Hindori-Mohangoo A, Blondel B, Gissler M, Kramer MR, Richards JL, Deb-Rinker P, Morisaki N, Nassar N, Nybo Andersen AM, Kramer MS, Zeitlin J: Can we apply a population approach to preterm birth prevention? An ecological study of preterm and early term births in 34 high-income countries. European Journal of Public Health  2017; Sep 8 doi: 10.1093/eurpub/ckx131[Epub ahead of print]
  58. Okubo Y*, Michihata N, Yoshida K, Morisaki N, Matsui H, Fushimi K, Yasunaga H: Impact of pediatric obesity on acute asthma exacerbation in Japan. Pediatric Allergy and Immunology  2017; Oct18  doi: 10.1111/pai.12801 [Epub ahead of print]
  59. Okubo Y*, Michihata N, Morisaki N, Sundel R, Yasunaga H: Association between dose of glucocorticoids and coronary artery lesions in Kawasaki disease. Arthritis Care & Research 2017; Oct 26 doi: 10.1002/acr.23456 [Epub ahead of print]
  60. Okubo Y*, Michihata N, Morisaki N, Uda K, Miyairi I, Ogawa Y, Matsui H, Fushimi K, Yasunaga H: Recent trends in practice patterns and impact of corticosteroid use on pediatric Mycoplasma pneumoniae -related respiratory infections RespiratoryInvestigation. 2017;Dec13.doi10.1016/j.resinv.2017.11.005. [Epub ahead of print]
  61. Okubo Y*, Michihata N, Uda K, Morisaki N, Miyairi I, Matsui H, Fushimi K, Yasunaga H: Dose-response relationship between weight status and clinical outcomes in children hospitalized with influenza-related respiratory infections. Pediatric Pulmonology (2017.11.27 in press)
  62. Ogawa K*, Morisaki N, Kobayashi M, Jwa SC, Tani Y, Sago H, Horikawa R, Fujiwara T: Maternal vegetable intake during early pregnancy has protective effect on subsequent childhood wheezing. European Journal of Clinical Nutrition (2017.11.30 in press)
  63. Takahashi T, Okubo Y, Handa A: Acute chest syndrome among children hospitalized with vaso-occlusive crises in the US. Pediatr Blood Cancer Accepted 2017; Nov 14.
  64. Horiuchi Y, Tanimoto S, Latif AHMM, Urayama KY, Aoki J, Yahagi K, Okuno T, Sato Y, Nakajima H, Hara K, Tanabe K Identifying Novel Phenotypes of Acute Heart Failure Using Cluster Analysis of Clinical Variables. 2018; In press
  65. Urayama KY, Takagi M, Kawaguchi T, Matsuo K, Tanaka Y, Ayukara Y, Arakawa Y, Hasegawa D, Yuza Y, Kaneko T, Noguchi T, Taneyama Y, Ota S, Inukai T, Yanagimachi M, Keino D, Koike K, Toyama D, Nakazawa Y, Kurosawa H, Nakamura K, Moriwaki K, Goto H, Sekinaka Y, Morita D, Kato M, Takita J, Tanaka T, Inazawa H, Koh K, Ishida Y, Ohara A, Mizutani S, Matsuda F, Manabe A: Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese. Scientific Reports 2018; 8:789. doi:10.1038/s41598-017-19127-7.
  66. Morimoto N, Kasuga C, Tanaka A, Kamachi K, Ai M, Urayama KY, Tanaka A Association between dietary fiber to carbohydrate intake ratio and insulin resistance in Japanese adults without diabetes. British Journal of Nutrition 2017 In press
  67. Okubo Y*, Michihata N, Morisaki N, Hangai M, Matsui H, Fushimi K, Yasunaga H: Recent trends in practice patterns and comparisons between immunoglobulin and corticosteroid in pediatric immune thrombocytopenia. International Journal of Hematology 2018 Jan;107(1):75-82
  68. Okubo Y*, Michihata N, Uda K, Morisaki N, Miyairi I, Matsui H, Fushimi K, Yasunaga H: Dose-response relationship between weight status and clinical outcomes in children hospitalized with influenza-related respiratory infections. Pediatric Pulmonology 2018 Feb;53(2):218-223
  69. Okubo Y*, Michihata N, Morisaki N, Uda K, Miyairi I, Ogawa Y, Matsui H, Fushimi K, Yasunaga H: Recent trends in practice patterns and impact of corticosteroid use on pediatric Mycoplasma pneumoniae-related respiratory infections. Respiratory Investigation 2018 Mar;56(2):158-165.
  70. Delnord M*, Mortensen L, Hindori-Mohangoo A, Blondel B, Gissler M, Kramer MR, Richards JL, Deb-Rinker P, Morisaki N, Nassar N, Nybo Andersen AM, Kramer MS, Zeitlin J. Can we apply a population approach to preterm birth prevention? An ecological study of preterm and early term births in 34 high-income countries. European Journal of Public Health. 2018 Apr 1;28(2):303-309.
  71. Okubo Y*, Morisaki N, Michihata N, Matsui H, Fushimi K, Yasunaga H: Dose-response relationship between weight status and clinical outcomes in infants hospitalized with respiratory syncytial virus infections. Pediatric Pulmonology 2018 Apr;53(4):461-466
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