国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

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研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

A.D.2013

小児血液・腫瘍研究部

原著論文(英文)

  1. Miyagawa Y, Okita H, Kiyokawa N. Induction of adipogenic differentiation in three-dimensional culture model on a novel microfabricated scaffold. Methods in Molecular Biology. 2013;952:275-86.
  2. Nemoto A, Inukai T, Uno K, Kiyokawa N, Miyagawa Y, Takahashi K, Sato H, Akahane K, Hirose K, Honna-Oshiro H, Goi K, Kagami K, Nakazawa S, Fujimoto J, Inaba T, Sugita K. Diverse underlying proliferation response to growth factors in imatinib-treated Philadelphia chromosome-positive leukemias. Leukemia Research. 2013 Jan;37(1):93-101.
  3. Yamada H, Iijima K, Tomita O, Taguchi T, Miharu M, Kobayashi K,Okita H, Saito M, Shimizu T, Kiyokawa N. Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia. International Journal of Hematology. 2013 Jan;97(1):73-82.
  4. Kato M, Yasui N, Seki M, Kishimoto H, Sato-Otsubo A, Hasegawa D, Kiyokawa N, Hanada R, Ogawa S, Manabe A, Takita J, Koh K. Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS in consequence of acquired uniparental disomy. The Journal of Pediatrics. 2013 Jun;162(6):1285-1288.
  5. Kobayashi K, Jakt L M, Nishikawa SI. Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn. Oncogene 2013 May 23;32(21):2640-8.
  6. Ueno H, Okita H, Akimoto S, Kobayashi K, Nakabayash K, Hata K, Fujimoto J, Hata L-I, Fukuzawa M, Kiyokawa N. DNA Methylation Profile Distinguishes Clear Cell Sarcoma of the Kidney from Other Pediatric Renal Tumors. PLoS ONE. 2013 Apr 26;8(4):e62233.
  7. Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T. Stability of genomic imprinting in human induced pluripotent stem cells. BMC Genetics. 2013 Apr 30;14(1):32.
  8. Tomizawa D, Tawa A, Watanabe T, Saito AM, Kudo K, Taga T, Iwamoto S, Shimada A, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Kiyokawa N, Isoyama K, Mizutani S, Hara J, Horibe K, Nakahata T, Adachi S.Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group. International Journal of Hematology. 2013 Nov;98(5):578-88.
  9. Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S. A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. Journal of Cell Science. 2013 Dec 1;126(Pt 23):5391-9.
  10. Nakamura H, Liao H, Minami K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Imadome KI, Inoue N, Fujiwara S. Human cytomegalovirus induces apoptosis in neural stem/progenitorcells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress. Herpesviridae. 2013 Oct 21;4(1):2.
  11. Fukushima H, Fukushima T, Sakai A, Suzuki R, Nakajima-Yamaguchi R, Kobayashi C, Iwabuchi A, Saito M, Yoshimi A, Nakao T, Kato K, Tsuchida M, Takahashi H, Koike K, Kiyokawa N, Noguchi E, Sumazaki R. Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies. Leukemia Research and Treatment. 2013;2013:238528.
  12. Satoh D, Maeda T, Ito T, Nakajima Y, Ohte M, Ukai A, Nakamura K, Enosawa S, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Matsunaga T. Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient. Genes to Cells. 2013 Dec;18(12):1053-69. 

分子内分泌研究部

原著論文(英文)

  1. Nagasaki K, Tsuchiya S, Saitoh A, Ogata T, Fukami M. Neuromuscular Symptoms in a Patient with Familial Pseudohypoparathyroidism Type Ib Diagnosed by Methylation-Specific Multiplex Ligation-Dependent Probe Amplification. Endocrine Journal. 60(2):231-236, 2013
  2. Ayabe T, Matsubara K. Ogata T, Ayabe A, Murakami N, Nagai T, Fukami M. Birth Seasonality in Prader-Willi Syndrome Resulting from Chromosome 15 Microdeletion. American Journal of Medical Genetics Part A. 161(6):1495-1497, 2013
  3. Yamaguchi R, Kato F, Hasegawa T, Katsumata N, Fukami M, Matsui T, Nagasaki K, Ogata T. A novel homozygous mutation of the nicotinamide nucleotide transhydrogenase gene in a Japanese patient with familial glucocorticoid deficiency. Endocrine Journal. 60(7):855-859, 2013 
  4. Fukami M, Iso M, Sato N, Igarashi M, Seo M, Kazukawa I, Kinoshita E, Dateki S, Ogata T. Submicroscopic deletion involving the fibroblast growth factor receptor 1 gene in a patient with combined pituitary hormone deficiency. Endocrine Journal. 60(8):1013-1020, 2013 
  5. Matsumura T, Imamichi Y, Mizutani T, Ju Y, Yazawa T, Kawabe S, Kanno M, Ayabe T, Katsumata N, Fukami M, Inatani M, Akagi Y, Umezawa A, Ogata T, Miyamoto K. Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. The FASEB Journal. 27(8):3198-3208, 2013
  6. Hayashi M, Kataoka Y, Sugimura Y, Kato F, Fukami M, Ogata T, Homma K, Hasegawa T, Oiso Y, Sasano H, Tanaka H. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol. The Tohoku Journal of Experimental Medicine. 231(2):75-84, 2013
  7. Igarashi M, Dung VC, Suzuki E, Ida S, Nakacho M, Nakabayashi K, Mizuno K, Hayashi Y, Kohri K, Kojima Y, Ogata T, Fukami M. Cryptic genomic rearrangements in three patients with 46,XY disorders of sex development. PLOS ONE. 8(7):e68194, 2013
  8. Fukami M, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Burger H, Simpson ER, Umezawa A, Shihara D, Nakabayashi K, Bulun SE, Shozu M, Ogata T. Genomic Basis of Aromatase Excess Syndrome: Recombination- and Replication-Mediated Rearrangements Leading to CYP19A1 Overexpression. The Journal of Clinical Endocrinology and Metabolism. 98(12):E2013-2021, 2013
  9. Nakashima S, Watanabe Y, Okada J, Ono H, Nagata E, Fukami M, Ogata T. Critical role of Yp inversion in PRKX/PRKY-mediated Xp;Yp translocation in a patient with 45,X testicular disorder of sex development. Endocrine Journal. 60(12):1329-1334, 2013
  10. Ikeda M, Hirano M, Shinoda K, Katsumata N, Furutama D, Nakamura K, Ikeda S, Tanaka T, Hanafusa T, Kitajima H, Kohno H, Nakagawa M, Nakamura Y, Ueno S. Triple A syndrome in Japan. Muscle & Nerve. 48(3):381-386, 2013
  11. Sasaki A, Sumie M, Wada S, Kosaki R, Kurosawa K, Fukami M, Sago H, Ogata T, Kagami M. Prenatal genetic testing for a microdeletion at chromosome 14q32.2 imprinted region leading to UPD(14)pat-like phenotype. American Journal of Medical Genetics Part A. 164A(1):264-266, 2013
  12. Fuke T, Mizuno S, Nagai T, Hasegawa T, Horikawa R, Miyoshi Y, Muroya K, Kondoh T, Numakura C, Sato S, Nakabayashi K, Tayama C, Hata K, Sano S, Matsubara K, Kagami M, Yamazawa K, Ogata T. Molecular and clinical studies in 138 Japanese patients with silver-russell syndrome. PLOS ONE. 8(3):e60105, 2013
  13. Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H. A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient. Clinical Genetics. 86(6):539-544, 2013
  14. Katoh M, Igarashi M, Fukuda H, Nakagama H, Katoh M. Cancer genetics and genomics of human.FOX family genes. Cancer Letters. 328:198-206, 2013
  15. Miyabayashi K, Katoh-Fukui Y, Ogawa H, Baba T, Shima Y, Sugiyama N, Kitamura K, Morohashi K. Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. PLOS ONE. 8:e68050, 2013

総説(英文)

  1. Fukami M, Homma K, Hasegawa T, Ogata T. Backdoor pathway for Dihydrotestosterone Biosynthesis: Implications for normal and abnormal human sex development. Developmental Dynamics. 242(4):320-329, 2013

免疫アレルギー研究部

原著論文(英文)

  1. Morita H, Nomura I, Orihara K, Yoshida K, Akasawa A, Tachimoto H, Ohtsuka Y, Namai Y, Futamura M, Shoda T, Matsuda A, Kamemura N, Kido H, Takahashi T, Ohya Y, Saito H, Matsumoto K: Antigen-specific T-cell responses in patients with non-IgE-mediated gastrointestinal food allergy are predominantly skewed to T(H)2. Journal of Allergy and Clinical Immunology 2013;131:590-592.
  2. Shoda T, Futamura K, Kobayashi F, Saito H, Matsumoto K, Matsuda A: Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells. Allergy 2013;68:1467-1470.
  3. Kojima R, Matsuda A, Nomura I, Matsubara O, Nonoyama S, Ohya Y, Saito H, Matsumoto K: Salivary cortisol response to stress in young children with atopic dermatitis. Pediatric Dermatology 2013;30:17-22.
  4. Kojima R, Fujiwara T, Matsuda A, Narita M, Matsubara O, Nonoyama S, Ohya Y, Saito H, Matsumoto K: Factors associated with steroid phobia in caregivers of children with atopic dermatitis. Pediatric Dermatology 2013;30:29-35.
  5. Ozeki N, Muneta T, Koga H, Katagiri H, Otabe K, Okuno M, Tsuji K, Kobayashi E, Matsumoto K, Saito H, Saito T, Sekiya I. Transplantation of achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect. Arthritis and Rheumatology 2013;65:2876-86.
  6. Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H. GATA-1 regulates the generation and function of basophils. Proceedings of Natural Academy of Science U S A 2013;110:18620-5.
  7. Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S. IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS ONE 2013;8:e78099.
  8. Matsuda K, Narita M, Sera N, Maeda E, Yoshitomi H, Ohya H, Araki Y, Kakuma T, Fukuoh A, Matsumoto K. Gene and cytokine profile analysis of macrolide-resistant Mycoplasma pneumoniae infection in Fukuoka, Japan. BMC Infectious Disease 2013;13:591.
  9. Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto-Sasaki T, Matsumoto K, Hashimoto N, Saito S, Ohmori K, Nagaoka M, Tokuhashi Y, Ra C, Okayama Y. Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcgamma receptor I and Fcgamma receptor II. Arthritis and Rheumatology 2013;65:109-19.
  10. Koketsu R, Yamaguchi M, Suzukawa M, Tanaka Y, Tashimo H, Arai H, Nagase H, Matsumoto K, Saito H, Ra C, Yamamoto K, Ohta K. Pretreatment with low levels of FcepsilonRI-crosslinking stimulation enhances basophil mediator release. International Archives of Allergy and Immunology 2013;161 Suppl 2:23-31.
  11. Fujishima H, Satake Y, Okada N, Kawashima S, Matsumoto K, Saito H. Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium. Annals of Allergy, Asthma and Immunology 2013;110:39-43.
  12. Fujishima H, Fukagawa K, Okada N, Takano Y, Hirai H, Nagata K, Hashida R, Matsumoto K, Saito H. Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. Annals of Allergy, Asthma and Immunology 2013;111:126-31.
  13. Miyazono A, Abe J, Ogura M, Sato M, Fujimaru T, Kamei K, Ito S. Successful remission induced by plasma exchange combined with leukocytapheresis against refractory systemic juvenile idiopathic arthritis. European Journal of Pediatrics 2013;173(12): 1557-1560.
  14. Fukuda S, Ito S, Oana S, Sakai H, Kato H, Abe J, Ito R, Saitoh A, Takayama JI. Late development of coronary artery abnormalities could be associated with persistence of non-fever symptoms in Kawasaki disease. Pediatric Rheumatology 2013;11: 28.
  15. Effects of transdermal tulobuterol in pediatric asthma patients on long-term leukotriene receptor antagonist therapy: results of a randomized, open-label, multicenter clinical trial in Japanese children aged 4-12 years. Katsunuma T, Fujisawa T, Nagao M, Akasawa A, Nomura I, Yamaoka A, Kondo H, Masuda K, Yamaguchi K, Terada A, Ikeda M, Nishioka K, Adachi Y, Kurihara K. Allergology International. 2013;62(1):37-43.

総説(英文)

  1. Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K: Gastrointestinal food allergy in infants. Allergology International 2013;62:297-307.
  2. Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, Saito H. Role of interleukin-33 in innate-type immune cells in allergy. Allergology International 2013;62:13-20.
  3. Morita H, Nomura I, Matsuda A, Saito H, Matsumoto K. Gastrointestinal food allergy in infants. Allergology International 2013;62:297-307.
  4. Matsumoto K, Saito H. Epicutaneous Immunity and onset of allergic diseases - Per-"eczema"tous sensitization drives the allergy march. Allergology International 2013;62:291-6.

成育遺伝研究部

英文原著

  1. Kawai T, Watanabe N, Yokoyama M, Arai K, Oana S, Harayama S, Yasui K, Oh-ishi T, Onodera M: Thalidomide attenuates excessive inflammation without interrupting lipopolysaccharide-driven inflammatory cytokine production in chronic granulomatous disease. Clinical Immunology. Biochemical and Biophysical Research Communications. 2013;147:122-128.
  2. Hamanaka S, Ooehara Jun, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H: Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method. 2013;435:586-591.
  3. Watanabe Y, Sasahara Y, Saoh M, Looi CY, Katayama S, Suzuki T, Suzuki N, Ouchi M, Horino S, Moriya K, Nanjyo Y, Onuma M, Kitazawa H, Irie M, Niizuma H, Uchiyama T, Rikiishi T, Kumaki S, Minegishi M, Wada T, Yachie A, Tsuchiya S, Kure S. A case series of CAEBV of children and young adults treated with reduced-intensity conditioning and allogeneic bone marrow transplantation: a single center study. European Journal of Haematology. 2013;91:242-248.
  4. Tornack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M: Ectopic runx1 expression rescues tal-1-deficiency in the generation of primitive and definitive hematopoiesis. PLoS One 2013;8(7):e70116.
  5. Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H: Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 2013;154:1112-1126
  6. Kobayashi M,Watanabe M, Matsunari H, Nakano K, Kanai T, Hayashida G, Matsumura Y, Kuramoto M, Sakai R, Arai Y, Umeyama K, Watanabe N, Onodera M, Nagaya M, Nagashima H: 20 generation and characterization of transgenic-cloned pigs expressing the far-red fluorescent protein monomeric plum. Reproduction, Fertility and Development. 2013;26:124-125.
  7. Horino S,Uchiyama T,So T,Nagashima H,Sun SL,Sato M,Asao A,Haji Y,Sasahara Y,Candotti F,Tsuchiya S,Kure S,Sugamura K,Ishii: Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. PLos One 2013;8:e71594. 

母児感染研究部 

英文原著

  1. Ikuta K, Minematsu T, Inoue N, Kubo T, Asano K, Ishibashi K, Imamura T, Nakai H, Yoshikawa T, Moriuchi H, Fujiwara S, Koyano S, Suzutani T. Cytomegalovirus (CMV) glycoprotein H-based serological analysis in Japanese healthy pregnant women, and in neonates with congenital CMV infection and their mothers. Journal of Clinical Virology. 58: 474-478, 2013.
  2. Nakamura H, Liao H, Minami K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Imadome K, Inoue N, and Fujiwara S. Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress. Herpesviridae. 4:2, 2013.
  3. Taniguchi R, Koyano S, Suzutani T, Goishi K, Ito Y, Morioka I, Oka A, Nakamura H, Yamada H, Igarashi T, Inoue N. Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease. International Journal of Infectious Diseases. 17(12): e1092-7, 2013.
  4. Yamamoto N., Nishimura N., Takeuchi M., Ito T., Yokozaki H., Hirase S., Kubokawa I., Mori T., Yanai T., Hayakawa A., Takeshima Y., Nishio H., Matsuo M., Imadome K., Iijima K. The emergence of CD20-/CD19- tumor cells after rituximab therapy for Epstein-Barr virus-associated post-transplant lymphoproliferative disorder complicated with hemophagocytic lymphohistiocytosis. European Journal of Pediatrics. 2014 Dec;173(12):1615-8. doi: 10.1007/s00431-013-2181-6. Epub 2013 Oct 30.

英文総説・著書

  1. Fujiwara S, Matsuda G, and Imadome K. Humanized mouse models of Epstein-Barr virus infection and associated diseases. Pathogens. 2: 153-176, 2013.

システム発生・再生医学研究部

英文原著

  1. Watanabe T, Oyama T, Asada M, Harada D, Ito Y, Inagawa M, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, *Asahara H. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genetics. 2013; 9(1): e1003132.
  2. Matsukawa T, *Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Research & Therapy. 2013; 15(1): R28.
  3. Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, *Wilhelm D. MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biology of Reproduction. 2013; 88(6): 143.
  4. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, *Asahara H. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis and Rheumatism. 2013; 65(8): 2081-2089.
  5. Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, *Asahara H. The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013; 8(10): e75754.
  6. *Takada S, Sato T, Ito Y, Yamashita S, Kato T, Kawasumi M, Kanai-Azuma M, Igarashi A, Kato T, Tamano M, *Asahara H. Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013; 8(10): e76004.
  7. Kato T, Miyata K, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, *Asahara H, *Takada S. Production of Sry knockout mouse using TALEN via oocyte injection. Scientific Reports. 2013; 3: 3136.
  8. Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, Lotz M, *Asahara H. Analysis of microRNAs expression in chondrosarcoma. Journal Orthopaedic Research. 2013; 31(12): 1992-1998.

薬剤治療研究部

英文原著

  1. Yasuoka Y, Kobayashi M, Sato Y, Zhou M, Abe H, Okamoto H, Nonoguchi H, Tanoue A, Kawahara K: The intercalated cells of the mouse kidney OMCDis are the target of the vasopressin V1a receptor axis for urinary acidification. Clinical and Experimental nephrology. 2013; 17: 783-792.
  2. Tezuka Y, Okada M, Tada Y, Yamauchi J, Nishigori H, Sanbe A:Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation. PLoS One, 2013 Apr 23; 8:e616492. 
  3. Terada N, Saitoh Y, Ohno N, Komada M, Yamauchi J, Ohno S: Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS.   Histochemistry and Cell Biology 2013 Aug;140(2):213-22
  4. Miyamoto Y, Torii T, Nakamura K, Takashima S, Sanbe A, Tanoue A, Yamauchi J: Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells. Cellular Signaling  2013; 25: 1379-1387.
  5. Torii T, Miyamoto Y, Onami N, Tsumura H, Nemoto N, Kawahara K, Kato M, Kotera J, Nakamura K, Tanoue A, Yamauchi J: In vivo expression of the Arf6 guanine-nucleotide exchange factor cytohesin-1 in mice exhibits enhanced myelin thickness in nerves. Journal of Molecular Neuroscience. 2013; 51, 522-531
  6. Nakamura K, Aizawa K, Yamauchi J, Tanoue A: Hyperforin inhibits cell growth and differentiation in mouse embryonic stem cells. Cell Proliferation. 2013 46, 529-537. 
  7. Sanbe A, Marunouchi T, Abe A, Tezuka Y, Okada M, Aoki S, Tsumura H, Yamauchi J, Tanonaka K, Nishigori H, Tanoue A:Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse The Journal of Biological Chemistry. 2013;288:8910-8921
  8. Miyamoto Y, Torii T, Yamamori N, Ogata T, Tanoue A, Yamauchi j:Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Science Signaling. (サイエンス姉妹誌) 2013;6, ra15: 論文掲載号の表紙に採用された。また、朝日新聞に報道された。

英文総説・著書

  1. Nakamura K, Tanoue A:Etiology of biliary atresia as a developmental anomaly: recent advances. Journal of hepato-biliary-pancreatic sciences. 2013 Jun; 20(5): 459-464.
  2. Torii T, MiyamotoY, Onami N, Tsumura H, Noriko Nemoto N, Kawahara K, Kato M, Kotera J, Nakamura K, Tanoue A, Yamauchi J. Hypermyelination phenotype in cytohesin-1 transgenic mice. Global Medical Discovery http://www.globalmedicaldiscovery.com/(2013年9月公開)

周産期病態研究部

英文原著

  1. Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma. Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K. BioMed Central Cancer. 2013;13:608
  2. Mutations in SERPINB7, Encoding a Member of the Serine Protease Inhibitor Superfamily, Cause Nagashima-type Palmoplantar Keratosis. Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosaki R, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M. The American Journal of Human Genetics. 2013;93:945-956
  3. Fluorescent-Ligand-Mediated Screening of G-Quadruplex Structures Using a DNA Microarray. Iida K, Nakamura T, Yoshida W, Tera M, Nakabayashi K, Hata K, Ikebukuro K, Nagasawa K. Angewandte Chemie International Edition 2013;52:12052-12055
  4. Genomic Basis of Aromatase Excess Syndrome: Recombination- and Replication-Mediated Rearrangements Leading to CYP19A1 Overexpression. Fukami M, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Burger H, Simpson ER, Umezawa A, Shihara D, Nakabayashi K, Bulun SE, Shozu M, Ogata T. The Journal of Clinical Endocrinology & Metabolism. 2013;98:E2013-E2021
  5. DNA methylation contributes to natural human variation. Heyn H, Moran S, Hernando-Herraez I, Sayols S, Gomez A, Sandoval J, Monk D, Hata K, Marques-Bonet T, Wang L, Esteller M. Genome Research. 2013;23:1363-1372
  6. Epigenomics comes of age with expanding roles in biological understanding and clinical application. Kubota T, *Hata K. Journal of Human Genetics. 2013;58:395
  7. Cryptic Genomic Rearrangements in Three Patients with 46, XY Disorders of Sex Development. Igarashi M, Dung VC, Suzuki E, Ida S, Nakacho M, Nakabayashi K, Mizuno K, Hayashi Y, Kohri K, Kojima Y, Ogata T, Fukami M. PLoS One. 2013;8:e68194
  8. Detection of histone modification by chromatin immunoprecipitation combined zinc finger luciferase-based bioluminescence resonance energy transfer assay. Yoshida W, Kezuka A, Abe K, Wakeda H, Nakabayashi K, Hata K, Ikebukuro K. Analytical Chemistry. 2013;85:6485-6490
  9. DNA methylation profile distinguishes clear cell sarcoma of the kidney from other pediatric renal tumors. Ueno H, Okita H, Akimoto S, Kobayashi K, Nakabayashi K, Hata K, Fujimoto J, Hata J, Fukuzawa M, Kiyokawa N. PLoS One. 2013;8:e62233
  10. Epigenetic Regulations in Placentation. Kusumi M, *Hata K. Journal of Mammalian Ova Research. 2013;30:11-15
  11. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. Nakamura K, Aizawa K, Nakabayashi K, Kato N, Yamauchi J, Hata K, Tanoue A. PLoS One. 2013;8:e54036

成育社会医学研究部

英文原著

  1. Fujiwara T, Ito J, Kawachi I. Income inequality, parental socioeconomic status and birth outcomes in Japan. Am J Epidemiol. 2013;177(10):1042-52.
  2. Ito J, Fujiwara T*, Bar RG. Does paternal infant care enhance exclusive breastfeeding? A population-based study in Japan. J Hum Lact. 2013;29(4):491-9. *Corresponding author
  3. Fujiwara T, Okuyama K. Mediators of intergenerational continuity of child maltreatment among Japanese Mothers. International Journal of Social Science Studies. 2013;1(2):181-189.
  4. Watanabe N, Morimoto S, Fujiwara T, Suzuki T, Taniguchi K, Mori F, Ando T, Watanabe D, Kimura T, Sago H, Ichihara A. Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester.. J Clin Endocrinol Metab. 2013;98(6):2528-35.
  5. Jwa SC, Fujiwara T*, Hata A, Arata N, Sago H, Ohya Y. BMI Mediates the Association between Low Educational Level and Higher Blood Pressure during Pregnancy in Japan. BMC Public Health. 2013;13:389. *Corresponding author
  6. Watanabe N, Morimoto S, Fujiwara T, Suzuki T, Taniguchi K, Ando T, Kimura T, Sago H, Ichihara A. Association between soluble (pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study. PLoS One. 2013;8(3):e60036.
  7. Parajuli RP, Fujiwara T, Umezaki M, Watanabe C. Association of Cord Blood Levels of Lead, Arsenic, and Zinc with Neurodevelopmental Indicators in Newborns: A Birth Cohort Study in Chitwan Valley, Nepal. Environ Res. 2013;121: 45-51.
  8. Matsuura N, Fujiwara T, Okuyama M, Izumi M. Testing a cascade model of linkage between child abuse and negative mental health among battered women in Japan. Asian Journal of Psychiatry. 2013;6(2):99-105.
  9. Kojima R, Fujiwara T, Matsuda A, Narita M, Matsubara O, Nonoyama S, Ohyta Y, Saito H, Matsumoto K. Factors Associated with Steroid Phobia in Caregivers of Children with Atopic Dermatitis. Pediatr Dermatol. 2013;30(1):29-35.
  10. Kakara H, Nishida Y, Sang Min Y, Miyazaki Y, Koizumi Y, Mizoguchi H, Yamanaka T: Development of Childhood Fall Motion Database and Browser Based on Behavior Measurements. Accident Analysis & Prevention 59: 2013;432-442
  11. Shrestha S, Aihara Y, Yoden K, Yamagata Z, Nishida K, Kondo N* : Access to improved water and its relationship with diarrhoea in Kathmandu Valley, Nepal: a cross-sectional study. British Medical Journal Open 3 2013;e002264 doi:10.1136/bmjopen-2012-002264
  12. Furuya Y*, Kondo N, Yamagata Z, Hashimoto Z: Health literacy, socioeconomic status, and self-rated health in Japan. Health Promotion International, 2013 Epub ahead of print.  DOI:10.1093/heapro/dat071
  13. Takagi D*, Kondo K, Kondo N, Cable N, Ikeda K, Kawachi I: Social disorganization/social fragmentation and risk of depression among older people in Japan: Multilevel investigation of indices of social distance. Social Science & Medicine 2013;83(0):81-9
  14. Aida J*, Kondo K, Kawachi I, Subramanian SV, Ichida Y, Hirai H, Kondo N, Osaka K, Sheiham A, Tsakos G, Watt RG : Does social capital affect the incidence of functional disability in older Japanese? A prospective population-based cohort study. Journal of Epidemiology and Community Health 2013; 67:42-7
  15. Suzuki K*, Miri S, Ando D, Kondo N, Yamagata Z: Differences in the effect of maternal smoking during pregnancy for childhood overweight before and after 5 years of age. Journal of Obstetrics and Gynaecology Research 2013; 39(5):914-921
  16. Shrestha S, Malla SS, Aihara Y, Kondo N, Nishida K: Water quality at supply source and point of use in the Kathmandu Valley. Journal of Water and Environment Technology 2013; 11: 331-340
  17. Yasuda T, Ojima T, Nakamura M, Nagai A, Tanaka T, Kondo N, Suzuki K, Yamagata Z: Postpartum smoking relapse among women who quit during pregnancy: cross-sectional study in Japan. The Journal of Obstetrics and Gynaecology Research 2013; 39(11):1505-12. doi: 10.1111/jog.12098
  18. Tsakos G, Sabbah W, Chandola T, Newton T, Kawachi I, Aida J, Sheiham A, Marmot MG, Watt RG: Social relationships and oral health among adults aged 60 years or older. Psychosom Med 2013, 75(2):178-186
  19. Takeuchi K, Aida J, Kondo K, Osaka K: Social participation and dental health status among older Japanese adults: a population-based cross-sectional study. PLoS One 2013; 8(4):e61741
  20. Hayasaka K, Tomata Y, Aida J, Watanabe T, Kakizaki M, Tsuji I: Tooth loss and mortality in elderly Japanese adults: effect of oral care. Journal of the American Geriatrics Society 2013; 61(5):815-820
  21. Tabuchi T, Ito Y, Ioka A, Nakayama T, Miyashiro I, Tsukuma H: Tobacco smoking and the risk of subsequent primary cancer among cancer survivors: a retrospective cohort study. Annals of Oncology. 2013;24(10):2699-2704
  22. Tabuchi T, Hoshino T, Nakayama T, Ito Y, Ioka A, Miyashiro I: Does removal of out-of-pocket costs for cervical and breast cancer screening work? A quasi-experimental study to evaluate the impact on attendance, attendance inequality and average cost per uptake of a Japanese government intervention. International Journal of Cancer. 2013;133(4):972-983
  23. Ikeda A, Miyashiro I, Nakayama T, Ioka A, Tabuchi T, Ito Y: Descriptive epidemiology of bile duct carcinoma in Osaka. Japanese Journal of Clinical Oncology. 2013;43(11):1150-1155
  24. Shinozaki K, Okuda M, Hinoda Y, Okayama N,Fukuda T, Kunitsugu I:Fat-mass and obesity-associated gene variant and changes of body massindex from ages 3 to 13 years. Obesity Research and Clinical Practice 8 2013;e382-e387
  25. Ichikawa K, Takahashi Y, Ando M, et al: TEACCH-based group social skills training for children with high-functioning autism: a pilot randomized controlled trial. BioPsychoSocial Medicine. 2013;7(1):14. 
  26. Ichikawa K, Takahashi Y, Ando M, et al: TEACCH-based group social skills training for children with high-functioning autism: a pilot randomized controlled trial. BioPsychoSocial Medicine. 2013;7(1):14.

英文総説・著書

  1. Fujiwara T, Michikawa T, Suzuki K, Takabayashi T, Yamagata Z. Impact of high-rise living on childrenon childrenng on children children on childrenioning autism: a pilot randomized controlled trial. attendaKawachi I, Ichida Y, Tampubolon G, Fujiwara T. Chapter 4. Causal inference in social capital research. In: Kawachi I, Takao S, Subramanian SV. (Eds). Global Perspectives on Social Capital and Health. New York: Springer; 2013.p87-122.
  2. Kondo N, Shirai K : Microfinance and health (Chapter 10). In., Kawachi I, SV Subramanian, Takao S (Eds.), Global perspectives on social capital and health. Springer, New York
  3. Aida J, Kawachi I, Subramanian SV, Katsunori K: Disaster, Social Capital, and Health. In: Global Perspectives on Social Capital and Health. Edited by Kawachi I, Takao S, Subramanian SV. New York: Springer; 2013; 167-187.

成育政策科学研究部

英文原著

森 臨太郎
  1. Morisaki N, Ganchimeg T, Ota E, Vogel JP, Souza JP, Mori R, and Gulmezoglu AM. Maternal and institutional characteristics associated with administering prophylactic antibiotics in cesarean delivery. An International Journal of Obstetrics and Gynaecology. 2014 Mar; 121 Suppl 1:66-75. doi: 10.1111/1471-0528.12632.
  2. Tobe-Gai R and Mori R. Micronutrient powders for young children. Lancet. 2013 Oct 5; 382(9899):1171-1172. 
  3. Akahira-Azuma M, Yonemoto N, Ganzorig B, Mori R, Hosokawa S, Matsushita T, Bavuusuren B, and Shonkhuuz E. Validation of a transcutaneous bilirubin meter in Mongolian neonates: comparison with total serum bilirubin. BMC Pediatrics 2013, 27; 13(1):151. 
  4. Yonemoto N, Dowswell T, Nagai S, and Mori R. Schedules for home visits in the early postpartum period. Cochrane Database of Systematic Reviews. 2013, Issue 7. Art. No.: CD009326. 
  5. Kenyon S, Tokumasu H, Dowswell T, Pledge D, and Mori R. High-dose versus low-dose oxytocin for augmentation of delayed labour. Cochrane Database of Systematic Reviews. 2013, Issue 7. Art No.: CD007201. 
  6. Yaju Y, Kataoka Y, Eto H, Horiuchi S, Mori R. Prophylactic interventions after delivery of placenta for reducing bleeding during the postnatal period. Cochrane Database of Systematic Reviews. 2013, Issue 11. Art. No.: CD009328. DOI: 10.1002/14651858.CD009328.pub2. 
  7. Souza JP, Gülmezoglu AM, Vogel JP, Carroli G, Lumbiganon P, Qureshi Z, Costa MJ, Fawole B, Mugerwa Y, Nafiou I, Neves I, Wolomby-Molondo J, Bang HT, Cheang K, Chuyun K, Jayaratne K, Jayathilaka CA, Mazhar SB, Mori R, Mustafa ML, Pathak LR, Perera D, Rathavy T, Recidoro Z, Roy M, Ruyan P, Shrestha N, Taneepanichsku S, Viet Tien N, Togoobaatar G, Wehbe M, Yadamsuren B, Yan W, Yunis K, Bataglia V, Cecatti JG, Hernandez-Prado B, Nardin JM, Narváez A, Ortiz-Panozo E, Pérez-Cuevas R, Valladares E, Zavaleta N, Armson A, Crowther C, Hogue C, Lindmark G, Mittal S, Pattinson R, Stanton ME, Campodonico L, Cuesta C, Giordano D, Intarut N, Laopaiboon M, Bahl R, Martines J, Mathai M, Merialdi M, and Say L. Beyond the coverage of essential interventions – the next challenge for reducing global maternal mortality: findings of the World Health Organization Multi-country Survey on Maternal and Newborn Health. Lancet. 2013;381(9879):1747-55
  8. Sasaki H, Yonemoto N, Hanada N, and Mori R. Methods for administering subcutaneous heparin during pregnancy. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD009136. 
  9. Kawaguchi A, Isayama T, Mori R, Minami H, Yang Y, and Tamura M. Hydralazine in infants with persistent hypoxemic respiratory failure. Cochrane Database of Systematic Reviews. 2013, Issue 2. Art. No.: CD009449. 
  10. Balogun OO, Hirayama F, Wariki WMV, Koyanagi A, and Mori R. Interventions for improving outcomes for pregnant women who have experienced genital cutting. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD009872. 
  11. Wariki WMV, Mori R, Boo NY, Fujimura M, Lee J, and Wong KY. Risk factors associated with outcomes of very low birth weight infants in four Asian countries. Journal of Pediatrics and Child Health. 2013;49(1):E23-7
  12. Chiba H, Masutani S, Toyoshima K, and Mori R. Indomethacin for preterm infants with intracranial hemorrhage. Pediatrics International. 2013 Feb; 55(1):124-6. doi: 10.1111/ped.12037.
  13. Tobe RG, Mori R, Huang L, Xu L, Han D and Shibuya K. Cost-effectiveness analysis of a national neonatal hearing screening program in China: conditions for the scale-up. PLoS One. 2013; 8(1):e51990. doi: 10.1371/journal.pone.0051990. Epub 2013 Jan 16.
  14. Ganchimeg T, Mori R, Ota E, Koyanagi A, Gilmour S, Shibuya K, Torloni MR, Betran AP, Seuc A, Vogel J, Souza JP. Maternal and perinatal outcomes among nulliparous adolescents in low- and middle-income countries: a multi-country study. An International Journal of Obstetrics and Gynaecology. 2013 Dec; 120(13):1622-30; discussion 1630. doi: 10.1111/1471-0528.12391. Epub 2013 Aug 7.
  15. Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M, Ebbesen F, Bell J, Mori R, Slusher TM, Fahmy N, Paul VK, Du L, Okolo AA, de Almeida MF, Olusanya BO, Kumar P, Cousens S, and Lawn JE. Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at a regional and global levels. Pediatric Research. 2013 Dec;74 Suppl 1:86-100.doi:10.1038/pr.2013.208
  16. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. Online First. DOI: http://dx.doi.org/10.1016/S0140-6736(14)61682-2 
  17. Tsuruta H, Karim D, Sawada T, and Mori R. Trained medical interpreters in a face-to-face clinical setting for patients with low proficiency in the local language (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD010421.

大田 えりか
  1. Wariki WMV, Nomura S, Ota E, Mori R, Shibuya K. Interventions for reduction of stigma in people with HIV/AIDS (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD006735. DOI: 10.1002/14651858.CD006735.pub2.
  2. Shiraishi M, Haruna M, Matsuzaki M, Ota E, Murayama R, Watanabe E, et al. Association between oxidized LDL and folate during pregnancy. Biological research for nursing. 2013; 15(2):213-8. doi: 10.1177/1099800411427581
  3. Shiraishi M, Haruna M, Matsuzaki M, Ota E, Murayama R, Sasaki S, et al. Relationship between plasma total homocysteine level and dietary caffeine and vitamin B intakes in pregnant women. Nursing & health sciences. 2013. doi: 10.1111/nhs.12080. Epub 2013/07/17.
  4. Abe SK, Balogun OO, Ota E, Mori R. Supplementation with multimicronutrients (excluding vitamin A) for breastfeeding women for improving outcomes for the mother and baby (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD010647. DOI: 10.1002/14651858.CD010647.
  5. Haruna, M, Watanabe, E, Matsuzaki, M, Ota, E, Shiraishi, M, Murayama, R, Yoshida, M and Yeo, S. The effects of an exercise program on health-related quality of life in postpartum mothers: A randomized controlled trial. Health. 2013; 5:432-439. doi: 10.4236/health.2013.53058.
  6. Togoobaatar G, Mori R, Ota E, Koyanagi A, Gilmour S, Shibuya K, Torloni M, Betran A, Seuc A, Vogel J, Souza JP. Maternal and perinatal outcomes among nulliparous adolescents in developing countries: A multi-country study. An International Journal of Obstetrics and Gynaecology (BJOG). 2013; 120(13):1622-30. doi: 10.1111/1471-0528.12391.

再生医療センター

英文原著

  1. Satoh D, Maeda T, Ito T, Nakajima Y, Ohte M, Ukai A, Nakamura K, Enosawa S, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Matsunaga T. Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient. Genes to Cells. 18(12):1053-1069, 2013.
  2. Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S. A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. Journal of Cell Science. 126(Pt 23):5391-5399, 2013.
  3. Fukami M, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Burger H, Simpson ER, Umezawa A, Shihara D, Nakabayashi K, Bulun SE, Shozu M, Ogata T. Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. The Journal of Clinical Endocrinology & Metabolism. 98(12):E2013-2021, 2013.
  4. Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Kuroiwa M, Poon SS, Arai T, Toyoda M, Akutsu H, Umezawa A, Nakamura K, Takubo K. Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization. Tissue & Cell. 45(6):407-413, 2013.
  5. Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarín JJ, Kuji N, Umezawa A, Yoshimura Y. Age-associated telomere shortening in mouse oocytes. Reproductive Biology and Endocrinology. 11:108, 2013.
  6. Kami D, Watakabe K, Yamazaki-Inoue M, Minami K, Kitani T, Itakura Y, Toyoda M, Sakurai T, Umezawa A, Gojo S. Large-scale cell production of stem cells for clinical application using the automated cell processing machine. BMC Biotechnology. 13:102, 2013.
  7. Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosaki R, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M. Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. American Journal of Human Genetics. 93(5):945-956, 2013.
  8. Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T. Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Molecular and Cellular Biology. 33(22):4434-4447, 2013.
  9. Nakamura H, Liao H, Minami K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Imadome K, Inoue N, Fujiwara S. Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress. Herpesviridae. 4(1):2, 2013.
  10. Ishimine H, Yamakawa N, Sasao M, Tadokoro M, Kami D, Komazaki S, Tokuhara M, Takada H, Ito Y, Kuno S, Yoshimura K, Umezawa A, Ohgushi H, Asashima M, Kurisaki A. N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation. Biochemical and Biophysical Research Communications. 438(4):753-759, 2013.
  11. Matsumura T, Imamichi Y, Mizutani T, Ju Y, Yazawa T, Kawabe S, Kanno M, Ayabe T, Katsumata N, Fukami M, Inatani M, Akagi Y, Umezawa A, Ogata T, Miyamoto K. Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB Journal. 27(8):3198-3208, 2013.
  12. Ito C, Yamatoya K, Yoshida K, Fujimura L, Hatano M, Miyado K, Toshimori K. Integration of the mouse sperm fertilization-related protein equatorin into the acrosome during spermatogenesis as revealed by super-resolution and immunoelectron microscopy. Cell and Tissue Research. 352(3):739-750, 2013.
  13. Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, Akutsu H, Hata K, Nakabayashi K, Kono T. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc. Epigenetics. 8(6):635-645, 2013.
  14. Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A. β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells. PLoS One. 8(5):e63265, 2013.
  15. Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T. Stability of genomic imprinting in human induced pluripotent stem cells. BMC Genetics. 14:32, 2013.
  16. Yazawa T, Kawabe S, Kanno M, Mizutani T, Imamichi Y, Ju Y, Matsumura T, Yamazaki Y, Usami Y, Kuribayashi M, Shimada M, Kitano T, Umezawa A, Miyamoto K. Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells. Molecular and Cellular Endocrinology. 369(1-2):42-51, 2013.
  17. Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J. Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN. STEM CELLS Translational Medicine. 2(4):265-273, 2013.
  18. Shiozaki Y, Kitajima T, Mazaki T, Yoshida A, Tanaka M, Umezawa A, Nakamura M, Yoshida Y, Ito Y, Ozaki T, Matsukawa A. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. International Journal of Nanomedicine 8:1349-1360, 2013.
  19. Sekine W, Haraguchi Y, Shimizu T, Yamato M, Umezawa A, Okano T. Chondrocyte differentiation of human endometrial gland-derived MSCs in layered cell sheets. Scientific World Journal. 2013:359109, 2013.

英文総説・著書

  1. Higuchi A, Ling QD, Chang Y, Hsu ST, Umezawa A. Physical cues of biomaterials guide stem cell differentiation fate. Chemical Reviews. 113(5):3297-3328, 2013.

実験動物管理室

英文原著

  1. Satoh D, Maeda T, Ito T, Nakajima Y, Ohte M, Ukai A, Nakamura K, Enosawa S, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Matsunaga T. Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient. Genes to Cells. 18(12):1053-1069, 2013.
  2. Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S. A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. Journal of Cell Science. 126(Pt 23):5391-5399, 2013.
  3. Fukami M, Tsuchiya T, Vollbach H, Brown KA, Abe S, Ohtsu S, Wabitsch M, Burger H, Simpson ER, Umezawa A, Shihara D, Nakabayashi K, Bulun SE, Shozu M, Ogata T. Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression. The Journal of Clinical Endocrinology & Metabolism. 98(12):E2013-2021, 2013.
  4. Terai M, Izumiyama-Shimomura N, Aida J, Ishikawa N, Kuroiwa M, Poon SS, Arai T, Toyoda M, Akutsu H, Umezawa A, Nakamura K, Takubo K. Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization. Tissue & Cell. 45(6):407-413, 2013.
  5. Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarín JJ, Kuji N, Umezawa A, Yoshimura Y. Age-associated telomere shortening in mouse oocytes. Reproductive Biology and Endocrinology. 11:108, 2013.
  6. Kami D, Watakabe K, Yamazaki-Inoue M, Minami K, Kitani T, Itakura Y, Toyoda M, Sakurai T, Umezawa A, Gojo S. Large-scale cell production of stem cells for clinical application using the automated cell processing machine. BMC Biotechnology. 13:102, 2013.
  7. Kubo A, Shiohama A, Sasaki T, Nakabayashi K, Kawasaki H, Atsugi T, Sato S, Shimizu A, Mikami S, Tanizaki H, Uchiyama M, Maeda T, Ito T, Sakabe J, Heike T, Okuyama T, Kosaki R, Kosaki K, Kudoh J, Hata K, Umezawa A, Tokura Y, Ishiko A, Niizeki H, Kabashima K, Mitsuhashi Y, Amagai M. Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis. American Journal of Human Genetics. 93(5):945-956, 2013.
  8. Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T. Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Molecular and Cellular Biology. 33(22):4434-4447, 2013.
  9. Nakamura H, Liao H, Minami K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Imadome K, Inoue N, Fujiwara S. Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress. Herpesviridae. 4(1):2, 2013.
  10. Ishimine H, Yamakawa N, Sasao M, Tadokoro M, Kami D, Komazaki S, Tokuhara M, Takada H, Ito Y, Kuno S, Yoshimura K, Umezawa A, Ohgushi H, Asashima M, Kurisaki A. N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation. Biochemical and Biophysical Research Communications. 438(4):753-759, 2013.
  11. Matsumura T, Imamichi Y, Mizutani T, Ju Y, Yazawa T, Kawabe S, Kanno M, Ayabe T, Katsumata N, Fukami M, Inatani M, Akagi Y, Umezawa A, Ogata T, Miyamoto K. Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB Journal. 27(8):3198-3208, 2013.
  12. Ito C, Yamatoya K, Yoshida K, Fujimura L, Hatano M, Miyado K, Toshimori K. Integration of the mouse sperm fertilization-related protein equatorin into the acrosome during spermatogenesis as revealed by super-resolution and immunoelectron microscopy. Cell and Tissue Research. 352(3):739-750, 2013.
  13. Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, Akutsu H, Hata K, Nakabayashi K, Kono T. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc. Epigenetics. 8(6):635-645, 2013.
  14. Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A. β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells. PLoS One. 8(5):e63265, 2013.
  15. Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T. Stability of genomic imprinting in human induced pluripotent stem cells. BMC Genetics. 14:32, 2013.
  16. Yazawa T, Kawabe S, Kanno M, Mizutani T, Imamichi Y, Ju Y, Matsumura T, Yamazaki Y, Usami Y, Kuribayashi M, Shimada M, Kitano T, Umezawa A, Miyamoto K. Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells. Molecular and Cellular Endocrinology. 369(1-2):42-51, 2013.
  17. Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J. Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN. STEM CELLS Translational Medicine. 2(4):265-273, 2013.
  18. Shiozaki Y, Kitajima T, Mazaki T, Yoshida A, Tanaka M, Umezawa A, Nakamura M, Yoshida Y, Ito Y, Ozaki T, Matsukawa A. Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4. International Journal of Nanomedicine 8:1349-1360, 2013.
  19. Sekine W, Haraguchi Y, Shimizu T, Yamato M, Umezawa A, Okano T. Chondrocyte differentiation of human endometrial gland-derived MSCs in layered cell sheets. Scientific World Journal. 2013:359109, 2013.

英文総説・著書

  1. Higuchi A, Ling QD, Chang Y, Hsu ST, Umezawa A. Physical cues of biomaterials guide stem cell differentiation fate. Chemical Reviews. 113(5):3297-3328, 2013.

RI管理室

英文原著

  1. Luo XY, Takahara T, Kawai K, Fujino M, Sugiyama T, Tsuneyama K, Tsukada K, Nakae S, Zhong L, Li Xiao K*. IFN- deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine and choline-deficient high fat diet. American Journal Physiology Gastrointestinal and Liver Physiology. 305(12): G891-9; 2013
  2. Hou J, Cai S, Kitajima Y, Fujino M, Ito H, Takahashi K, Abe F, Tanaka T, Ding Q, Li Xiao K*. 5-aminolevulinic acid combined with ferrous iron induces carbon monoxide generation in mouse kidneys and protects from renal ischemic-reperfusion injury. American Journal Physiology Renal Physiology 305(8): F1149-57; 2013.
  3. Liu C, Zhu P, Saito T, Isaka Y, Nagahara Y, Zhuang J, Li Xiao K*. Non-myeloablative conditioning is sufficient to induce mixed chimerism and subsequent acceptance of donor specific cardiac and skin grafts. International Immunopharmacology 16(3): 392-8; 2013.

実験動物室

英文原著

  1. CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells. Bhuyan ZA, Arimochi H, Nishida J, Kataoka K, Kurihara T, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Yasutomo K. Biochemical and Biophysical Research Communications. 2014 Feb 21;444(4):628-33.2013
  2. Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse. Sanbe A, Marunouchi T, Abe T, Tezuka Y, Okada M, Aoki S, Tsumura H, Yamauchi J, Tanonaka K, Nishigori H, Tanoue A. The Journal of Biological Chemistry. 2013 Mar 29;288(13):8910-21.
  3. In vivo expression of the arf6 Guanine-nucleotide exchange factor cytohesin-1 in mice exhibits enhanced myelin thickness in nerves. Torii T, Miyamoto Y, Onami N, Tsumura H, Nemoto N, Kawahara K, Kato M, Kotera J, Nakamura K, Tanoue A, Yamauchi J. Journal of Molecular Neuroscience. 2013 Oct;51(2):522-31.