国立研究開発法人 国立成育医療研究センター National Center for Child Health and Development

  • Font--more Large--

Tel: +81-3-3416-0181 / Reservation(Hospital): 03-5494-7300
〈Monday~Friday(except national holiday)9A.M.〜17P.M.〉

  • Access
  • Contact Us
  • MENU

研究者・企業の方へ Scholar & Enterprise

研究者・企業の方へ Scholar & Enterprise

A.D.2010

小児血液・腫瘍研究部

原著論文(英文)

  1. Watanabe N, Okita H, Matsuoka K, Kiyotani C, Fujii E, Kumagai M, Nakagawa A. Vaginal yolk sac (endodermal sinus) tumors in infancy presenting persistent vaginal bleeding. J Obstet Gynaecol Res. 2010 Feb;36(1):213-6.
  2. Akahane K, Inukai T, Inaba T, Kurosawa H, Look AT, Kiyokawa N, Fujimoto J, Goto H, Endo M, Zhang X, Hirose K, Kuroda I, Honna H, Kagami K, Goi K, Nakazawa S, Sugita K. Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor. Leukemia. 2010 Apr;24(4):865-9.
  3. Onda K, Iijima K, Katagiri YU, Okita H, Saito M, Shimizu T, Kiyokawa N. Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma. Int J Hematol. 2010 Jun;91(5):808-19.
  4. Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Honna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T, Sugita K. Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood. 2010 Aug 12;116(6):962-70.
  5. Sasaki N, Hirano T, Kobayashi K, Toyoda M, Miyakawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nishihara S. Chemical inhibition of sulfation accelerates neural differentiation of mouse embryonic stem cells and human induced pluripotent stem cells. Biochem Biophys Res Commun. 2010 Oct 22;401(3):480-6.
  6. Kaneko T, Okita H, Nakajima H, Iijima K, Ogasawara N, Miyagawa Y, Katagiri YU, Nakagawa A, Kiyokawa N, Sato T, Fujimoto J. Neuroblastoma cells can be classified according to distinctive glycosphingolipid expression profiles identified by liquid chromatography-tandem mass spectrometry. Int J Oncol. 2010 Nov;37(5):1279-88.
  7. Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A. Defining hypo-methylated regions of stem cell-specific promoters inhuman iPS cells derived from extra-embryonic amnions and lung fibroblasts. PLoS One. 2010 Sep 27;5(9):e13017.
  8. Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T, Furue MK, Mizuguchi H. Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol. Ther. (in press).
  9. Ogasawara N, Katagiri YU, KiyokawaN, Kaneko T, Sato B, Nakajima H, Miyagawa Y, Kushi Y, Ishida H, Kiso M, Okita H, Sato T, Fujimoto J. Accelerated biosynthesis of neolactoseries-glycosphingolipids in differentiated mouse embryonal carcinoma F9 cells detected by using dodecyl N-acetylglucosaminide as a saccharide primer. J Biochem (in press).
  10. Ohta H, Iwamoto S, Kiyokawa N, Tsurusawa M, Deguchi T, Takase K, Fujimoto J, Horibe K, Komada Y. Flow cytometric analysis of de novo acute myeloid leukemia in childhood: report from the Japanese Pediatric Leukemia/Lymphoma Study Group. Int J Hematol. (in press).
  11. Hasegawa D, Manabe A, Ohara A, Kikuchi A, Koh K, Kiyokawa N, Fukushima T, Ishida Y, Saito T, Hanada R, Tsuchida M. The Utility of Performing the Initial Lumbar Puncture on Day 8 in Remission Induction Therapy for Childhood Acute Lymphoblastic Leukemia: TCCSG L99-15 Study. Pediatric Blood & Cancer. (in press)
  12. Miyagawa Y, Okita H, Hiroyama M, Sakamoto R, Kobayashi M, Nakajima H, Katagiri YU, Fujimoto J, Hata JI, Umezawa A, Kiyokawa N. A microfabricated scaffold induces the spheroid formation of human bone marrow-derived mesenchymal progenitor cells and promotes efficient adipogenic differentiation. Tissue Eng Part A. (in press)

分子内分泌研究部

原著論文(英文)

  1. Dateki S, Kosaka K, Hasegawa K, Tanaka H, Azuma N, Yokoya S, Muroya K, Adachi M, Tajima T, Motomura K, Kinoshita E, Moriuchi H, Sato N, Fukami M, Ogata T*. Heterozygous OTX2 mutations are associated with variable pituitary phenotype. J Clin Endocrinol Metab 95 (2): 756–764, 2010. (IF = 6.202)
  2. Fukami M, Maruyama T, Dateki S, Sato N, Yoshimura Y, Ogata T*. Hypothalamic dysfunction in a female with isolated hypogonadotropic hypogonadism and compound heterozygous TACR3 mutations and clinical manifestation in her heterozygous mother. Horm Res Peadiatr 73 (6): 477–481, 2010. (IF = 1.730)
  3. Muroya K, Mochizuki T, Fukami M, Iso M, Fujita K, Ogata T*. Diabetes mellitus in a Japanese girl with HDR syndrome and GATA3 mutation. Endocr J 157 (2): 171–174, 2010. (IF = 1.806)
  4. Fukami M*, Nagai T, Mochizuki H, Muroya K, Yamada G, Takitani K, Ogata T. Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency. Mol Genet Metab 100 (3): 269–273, 2010. (IF = 2.897)
  5. Ashkenazi-Hoffnung L, Lebenthal Y, Wyatt AW, Ragge NK, Dateki S, Fukami M, Ogata T, Phillip M*, Gat-Yablonski G. A novel loss of function mutation in OTX2 is associated with phenotypically variable anophthalmia and isolated growth hormone deficiency. Hum Genet 127 (6): 721–729, 2010. (IF = 4.523)
  6. Iijima K*, Nozu K, Kamei K, Nakayama M, Ito S, Matsuoka K, Ogata T, Kaito H, Nakanishi K, Mastuo M. Severe Alport syndrome in a young woman caused by a t(X;1)(q22.3;p36.32) balanced translocation. Pediatr Nephrol 25 (10): 2165–2170, 2010. (IF = 2.425)
  7. Dateki S, Fukami M, Uematsu A, Kaji M, Iso M, Ono M, Mizota M, Yokoya S, Motomura K, Kinoshita E, Moriuchi H, Ogata T*. Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. J Clin Endocrinol Metab 95 (8): 4043–4047, 2010. (IF = 6.202)
  8. Kagami M, O'Sullivan MJ, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T*. The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers. PLoS Genet 6 (6): e1000992, 2010. (IF = 9.532)
  9. Yamazawa K, Nakabayashi K, Kagami M, Sato T, Saitoh S, Horikawa R, Hizuka N, Ogata T*. Parthenogenetic chimaerism/mosaicism with a Silver-Russell Syndrome-like Phenotype. J Med Genet 47 (11): 782–785, 2010. (IF = 5.751)
  10. Kato H, Yoshida R, Tsukamoto K, Suga H, Eto H, Higashino T, Araki J, Ogata T, Yoshimura K*: Familial cases of atypical clinical features genetically diagnosed as LEOPARD syndrome (multiple lentigines syndrome). Int J Dermatol 49 (10): 1146–1151, 2010. (IF = 1.177)
  11. Hiraoka M*, Takahashi H, Orimo H, Hiraoka M, Ogata T, Azuma N: Genetic screening of Wnt signaling factors in advanced retinopathy of prematurity. Mol Vis 16 (12): 2572–2577, 2010. (IF = 2.541)
  12. Matsubara K, Iwamoto H, Yoshida A, Ogata T*: Semen analysis and successful paternity by intracytoplasmic sperm injection in a man with steroid 5-reductase-2 deficiency. Fertil Steril 94 (7): 2770.e7–2770.e10, 2010. (IF = 3.970)
  13. Suzumori N*, Ogata T, Mizutani E, Hattori Y, Matsubara K, Kagami M, Suguhara-Ogasawara M: Prenatal diagnosis of paternal uniparental disomy 14: delineation of further patient. Am J Med Genet A 152A (12): 3189–3192, 2010. (IF = 2.404)
  14. Inoue H*, Kangawa N, Kinouchi A, Sakamoto Y, Kimura C, Horikawa R, Shigematsu Y, Itakura M, Ogata T, Fujieda K: Identification and functional analysis of novel human growth hormone-releasing hormone receptor (GHRHR) gene mutations in Japanese subjects with short stature. Clin Endocrinol [Epub ahead of print] 2010 Nov 2 doi: 10.1111/j.1365-2265.2010.03911.x.. (IF = 3.201)
  15. Yamazawa K, Nakabayashi K, Matsuoka K, Matsubara K, Hata K, Horikawa R, Ogata T*: Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd(14)pat-like phenotypes. J Hum Genet 56 (1): 91–93, 2011. (IF = 2.547)
  16. Inoue H*, Kangawa N, Kinouchi A, Sakamoto Y, Kimura C, Horikawa R, Shigematsu Y, Itakura M, Ogata T, Fujieda K: Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature. J Clin Endocrinol Metab 2010 Nov 17. [Epub ahead of print]. (IF = 6.202)
  17. Dateki S, Fukami M, Tanaka Y, Sasaki G, Moriuchi H, Ogata T*: Identification of chromosome 15q terminal deletion with telomere sequences and its bearing on genotype-phenotype analysis. Endocr J (accepted).
  18. Fukami M, Muroya K, Miyake T, Iso M, Yokoi H, Suzuki Y, Tsubouchi K, Nakagomi Y, Kikuchi N, Horikawa R, Ogata T*: GATA3 abnormalities in six patients with HDR syndrome. Endocr J (accepted).
  19. Miyazaki O*, Nishimura G, Kagami M, Ogata T: Radiological evaluation of dysmorphic thorax in paternal uniparental disomy for chromosome 14. Ped Radiol (accepted).
  20. Kalfa N, Cassorla F, Abdennabi IO, Audran F, Philibert P, Daures JP, Baskin L, Fukami M, Ogata T, C Sultan C*: Exonic polymorphisms of MAMLD1 (CXorf6) are associated with hypospadias. J Urol (accepted).
  21. Fukami, Shozu M, Soneda S, Kato F, Inagaki A, Takagi H, Hanaki K, Kanzaki S, Ohyama K, Sano T, Nishigaki T, Yokoya S, Binder G, Horikawa R, Ogata T*: Aromatase excess syndrome: identification of cryptic duplications and deletions leading to gain-of-function of CYP19A1 and assessment of phenotypic determinants. (accepted).
  22. Katsumata N*, Ogawa E, Fujiwara I, Fujikura K. Novel CYP17A1 mutation in a Japanesepatient with combined 17α-hydroxylase/17,20-lyase deficiency. Metabolism 59(2):275-278, 2010.
  23. Goto M*, Mabe H, Nishimira G, Katsumata N. Progressive osseous heteroplasia caused by a novel nonsense mutation in the GNAS1 gene. J Pediatr Endocrinol Metab 23(3):303-309, 2010.
  24. Katsumata N*, Shinagawa T, Horikawa R, Fujikura K. IVS9-9C>A, not IVS9-9A>C, mutation in CYP21A2 causes classic salt-wasting steroid 21-hydroxylase deficiency. Metabolism 59(10):e12, 2010.
  25. Katsumata N*, Shinagawa T, Horikawa R, Fujikura K. Novel intronic CYP21A2 mutation in a Japanese patient with classic salt-wasting steroid 21-hydroxylase deficiency. Metabolism 59(11):1628-1632, 2010.
  26. Nagasaki K, Katsumata N, Ogawa Y, Kikuchi T, Uchiyama M. Novel C617Y mutation in the 7th transmembrane segment of luteinizing hormone/choriogonadotropin receptor in a Japanese boy with peripheral precocious puberty. Endocr J 57(12): 1055-1060, 2010.

英文総説・著書

  1. Yamazawa K, Ogata T, Ferguson-Smith AC*: Uniparental disomy and human disease: an overview. Am J Med Genet C (Seminars in Medical Genetics) 154C (3): 329–334, 2010. (IF = 2.404)
  2. Kawano N, Harada Y, Yoshida K, Miyado M, Miyado K: Role of CD9 in sperm-egg fusion and its general role in fusion phenomena. Cell Fusions: regulation and control: 171-184, 2010.

免疫アレルギー研究部

原著論文(英文)

  1. Tsubota A, Matsumoto K, Mogushi K, Nariai K, Namiki Y, Hoshina S, Hano H, Tanaka H, Saito H, Tada N. IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress. Carcinogenesis 2010 Mar;31(3):504-11. 
  2. Matsumoto Y, Imai Y, Sugita Y, Tanaka T, Tsujimoto G, Saito H, Oshida T. CCDC132 is highly expressed in atopic dermatitis T cells. Mol Med Rep 2010; 3(1): 83-87.
  3. Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP. IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J Clin Immunol 2010 Mar;30(2):235-40. 
  4. *Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol. 2010 Apr 15;184(8):4414-4422.
  5. Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A. Cells of extraembryonic mesodermal origin confer human dystrophin in the Mdx model of duchenne muscular dystrophy. J Cell Physiol 2010 Jun;223(3):695-702. 
  6. Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human b-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. J Immunol 2010 Apr 1;184(7):3526-34. 
  7. Futamura K, Orihara K, Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A. b2-adrenoceptor agonists enhance cytokine-induced release of thymic stromal lymphopoietin by lung tissue cells. Int Arch Allergy Immunol 2010 Jul;152(4):353-61. 
  8. Kajiwara N, Sasaki T, Cruse G, Bradding P, Ohmori K, Saito H, Ra C, Okayama Y. Activation of human lung mast cells through platelet activating factor receptor. J Allergy Clin Immunol 2010 May;125(5):1137-1145.e6. 
  9. Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S. Amphiregulin Is not essential for ovalbumin-induced acute airway inflammation in mice. Allergol Int 2010 Jun;59(2):207-11. 
  10. Matsumoto K, Terakawa M, Fukuda S, Saito H. Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis. Int Arch Allergy Immunol 2010;152 Suppl 1:2-8.
  11. *Oh I, Ozaki K, Meguro A, Hatanaka K, Kadowaki M, Matsu H, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard WJ, Ozawa K. Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2010 Aug 1;185(3):1920-1926. 
  12. Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M. TSLP promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol (Epub 2010 Jul 23) 
  13. *Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, Iwakura Y. TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice. J Immunol. 2010 Aug 1;185(3):1887-1893. 
  14. Yagami A, Kajiwara N, Oboki K, Ohno T, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H, Nakae S. Amphiregulin is not essential for induction of contact hypersensitivity. Allergol Int 2010 Sep;59(3):277-284.
  15. Watanabe K, Penfold ME, Matsuda A, Ohyanagi N, Kaneko K, Matsumoto K, Schall TJ, Miyasaka N, Nanki T. Pathogenic Role of CXCR7 in Rheumatoid Arthritis. Arthritis Rheum 2010 Nov;62(11):3211-3220.
  16. Fukuie T, Nomura I, Horimukai K, Futamura M, Narita M, Ohzeki T, Matsumoto K, Saito H, Ohya Y. Proactive treatment appears to decrease serum IgE levels in patients with severe atopic dermatitis. Brit J Dermatol 2010 Nov;163(5):1127-1129.
  17. Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y. Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition. J Invest Dermatol Epub 2010 Dec;130(12):2760-2767.
  18. *Jin SL, Goya S, Nakae S, Wang D, Bruss M, Hou C, Umetsu D, Conti M. Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 2010 Dec;126(6):1252-9.e12.
  19. Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S. Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. Allergol Int 2010 Dec;59(4):399-408.
  20. Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A. IL-33 mediates inflammatory responses in human lung tissue cells. J Immunol 2010 Nov 15;185(10):5743-5750.
  21. Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S. IL-33 is a crucial amplifier for innate rather than acquired immunity. Proc Natl Acad Sci USA 2010 Oct 26;107(43):18581-6. 
  22. Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, Sekiya I. Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther 2010 Nov 5;12(6):R206.
  23. Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T. Identification of INAM, a polyI:C-inducible membrane protein, that participates in dendritic cell-mediated natural killer cell activation. J Exp Med 2010 Nov 22;207(12):2675-2687.
  24. Ishibashi O, Ikegame M, Takizawa F, Yoshizawa T, Ali MM, Iizawa F, Mera H, Matsuda A, Kawashima H. Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of smad-1/5/8 phosphorylation. J Cell Physiol 2010; 222(2):465-473
  25. Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H. Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells. Int Arch Allergy Immunol 2011 Feb;154(3):184-194. 
  26. Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K. Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology. 2011 Apr; 132(4):527-539.
  27. Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K. Cluster analysis reveals four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms. J Allergy Clin Immunol 2011 Mar;127(3):685-688.e8.
  28. Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K. Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of Human Basophils. J Immunol. 2011 Mar 18. [Epub ahead of print]
  29. Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito H, Matsumoto K. Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro. Int Arch Allergy Immunol 2011 (in press)
  30. Matsumoto K, Fukuda S, Hashimoto N, Saito H. Human eosinophils produce and release a novel chemokine, CCL23, in vitro. Int Arch Allergy Immunol 2011 (in press)
  31. Yamada Y, Nishi A, Ebara Y, Kato M, Yamamoto H, Morita H, Nomura I, Matsumoto K, Hirato J, Hatakeyama S, Suzuki N, Hayashi Y. Eosinophilic gastrointestinal disorders (EGIDs) in infants - A Japanese case series. Int Arch Allergy Immunol 2011 (in press)
  32. Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y. Increased production of vascular endothelial growth factor-D and lymphangiogenesis in Kawasaki disease. Circulation J 2011 (in press)

英文総説・著書

  1. Suzukawa M, Yamaguchi M, Iikura M, Koketsu R, Komiya A, Nagase H, Nakae S, Matsumoto K, Saito H, Matsushima K, Yamamoto K, Ohta K. IL-33-induced activation of human basophils and eosinophils. Inflammation and Regeneration 2010 May; 30(5):181-5.
  2. Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S. IL-33 and IL-33 receptors in host defense and diseases. Allergol Int. 2010 Jun;59(2):143-60. 
  3. Toyoda M, Hamatani T, Okada H, Matsumoto K, Saito H, Umezawa A. Defining Cell Identity by Comprehensive Gene Expression Profiling. Curr Med Chem 2010;17(28):3245-52. Epub 2010 Jul 29.
  4. *Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity. 2011 Feb 25;34(2):149-62.
  5. Oboki K, Nakae S, Matsumoto K, Saito H. IL-33 and airway inflammation. Allergy Asthma Immunol Res 2011 April;3(2):81-88.
  6. Saito H. Mast cell-specific genes as new drug targets. In “Allergy Frontiers: Future Perspectives” (p.323) ed. by Pawankar R, Holgate ST and Rosenwasser L. Springer, Tokyo, 2010: 179-190.
  7. Matsumoto K, Bochner BS. Adhesion molecules: interactions between cells and with the extracellular matrix. In: Lee JJ and Rosenberg HF, ed. Eosinophils in Health and Disease. International Eosinophil Society, 2011 In press.

成育遺伝研究部

英文原著

  1. Tozuka Y, Kumon M, Wada E, Onodera M, Mochizuki H, Wada K: Material obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int 57: 235-247, 2010.
  2. Hirata Y Hamanaka S, Onodera M: Transactivation of the dopamine receptor 3 gene by a single provirus integration results in development of B cell lymphoma in transgenic mice generated from retrovirally transduced embryonic stem cells. Blood 115: 3930-3938, 2010. 
  3. Miyamoto N, Tanaka R, Shimura H, Watanabe T, Mori H, Onodera M, Mochizuki H, Hattori N, Urabe T: Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain. J Cereb Blood Flow Metab 30: 299-310, 2010
  4. Kobayashi H, Shimada Y, Ikegami M, Kawai T, Sakurai K, Urashima T, Ijima M, Fujiwara M, Kaneshiro K, Ohashi T, Eto Y, Ishigaki K, Osawa M, Kyosen SO, Ida H: Prognostic factors for the late onset Pompe disease with enzyme replacement therapy: From our experience of 4 cases including an autopsy case. Mol Genet Metab. 2010;100;14-19
  5. Kawai T, Kusakabe H, Seki A, Kobayashi K, Onodera M: Osteomyelitis Due to Trimethoprim/Sulfamethoxazole-Resistant Edwardsiella tarda Infection in a Patient with X-linked Chronic Granulomatous Disease. Infection 2011 [in press]

母児感染研究部

英文原著

  1. Arai, A., Imadome, K., Fujiwara, S. and Miura O. Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells in an elderly man. Inter Med 49: 325-329, 2010.
  2. Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T. Gp91(phox) (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation 7:41-51, 2010.
  3. Shigeta T, Imadome K, Sakamoto S, Fukuda A, Kakiuchi T, Matsumoto N, Tanaka H, Nakazawa A, and Kasahara M. Epstein-Barr virus infection after pediatric lifing-related liver transplantation― management and risk factors. Pransplant Proc. 42: 4178-80, 2010.
  4. Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R. Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1 via late-phase activation of nuclear factor B and expression of phagocyte-type NADPH-oxidase. J Biol Chem. (in press )
  5. Imadome K, Yajima M, Arai A, Nakazawa A, Kawano1 F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura, O, Komano J, and Fujiwara S. Novel Mouse Xenograft Models Reveal a Critical Role of CD4+ T Cells in the Proliferation of EBV-Infected T and NK Cells. PLoS Pathogens, in revision. 

システム発生・再生医学研究部

英文原著

  1. Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, Lotz M, Asahara H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Mod Rheumatol. 2010; 20(1): 11-17.
  2. Nakanishi K, Nakasa T, Tanaka N, Ishikawa M, Yamada K, Yamasaki K, Kamei N, Izumi B, Adachi S, Miyaki S, Asahara H, Ochi M. Responses of microRNAs 124a and 223 following spinal cord injury in mice. Spinal Cord. 2010; 48(3): 192-196.
  3. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H. MicroRNA-140 plays dual roles both in cartilage development and homeostasis. Genes Dev. 2010; 24(11): 1173-1185.
  4. Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H. The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci U S A. 2010; 107(23): 10538-10542.
  5. MizutaniR, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A. Developmental expression of sorting nexin 3 in the mouse central nervous system. Gene Expr Patterns. Epub 2010 Sep 9.
  6. Asada M, Rauch A, Shimizu H, Maruyama H, Miyaki S, Shibamori M, Kawasome H, Ishiyama H, Tuckermann J, Asahara H. DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression. Lab Invest. Epub 2010 Oct 18.
  7. Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H. Array-based genomic resequencing of human leukemia. Oncogene. 2010; 29(25): 3723-3731.
  8. Hatanaka H, Takada S, Tsukui M, Choi YL, Kurashina K, Soda M, Yamashita Y, Haruta H, Hamada T, Tamada K, Hosoya Y, Sata N, Nagai H, Yasuda Y, Sugano K, Mano H. Identification of the transforming activity of Indian hedgehog by retroviral expression screening. Cancer Sci. 2010; 101(1): 60-64.

英文総説・著書

  1. Furumatsu T, Asahara H. Histone acetylation influences the activity of Sox9-related transcriptional complex. Acta Med Okayama. 2010; 64(6): 351-357.

薬剤治療研究部

英文原著

  1. Ishizuka Y, Abe H, Tanoue A, Kannan H, Ishida Y. Involvement of vasopressin V1b receptor in anti-anxiety action of SSRI and SNRI in mice. Neurosci Res. 2010 Mar;66(3):233-7.
  2. Oikawa R, Hosoda C, Nasa Y, Daicho T, Tanoue A, Tsujimoto G, Takagi N, Tanonaka K, Takeo S. Decreased Susceptibility to Salt-induced Hypertension in Subtotally Nephrectomized Mice Lacking the Vasopressin V1a Receptor. Cardiovasc Res. 2010 Jul 1;87(1):187-94. 
  3. Yamauchi J, Torii T, Kusakawa S, Sanbe A, Nakamura K, Takashima S, Hamasaki H, Kawaguchi S, Miyamoto Y, Tanoue A. The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway. J Neurosci Res. 2010 Nov 1;88(14):3189-97.
  4. Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A. Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6. J Biol Chem. 2010 Jul 30;285(31):24270-81.
  5. Kusakawa S, Nakamura K, Miyamoto Y, Sanbe A, Torii T, Yamauchi J, Tanoue A. Fluoxetine promotes gliogenesis during neural differentiation in mouse ES cells. J Neurosci Res. 2010 Dec;88(16):3479-87.
  6. Suzuki K, Takigawa W, Tanigawa K, Nakamura K, Ishido Y, Kawashima A, Wu H, Akama T, Sue M, Yoshihara A, Mori S, Ishii N. Detection of Mycobacterium leprae DNA from archaeological skeletal remains in Japan using whole genome amplification and polymerase chain reaction. PLoS One. 2010 Aug 26;5(8):e12422.

英文総説・著書

  1. Yuki Miyamoto, and Junji Yamauchi (2010) Cellular signaling of Dock family proteins in neural functions. Cell. Signal. 22, 175-182

著書(欧文)

  1. Ozawa F, Miyagawa Y, Hiroyama M, Kiyokawa N, Umezawa A, Tanoue A, Tanaka S. A New Approach for Drug Discovery and Differentiation Study Using Cutting-Edge 3d Cell Culture System. BASIC AND APPLIED ASPECTS. Animal Cell Technology: Basic & Applied Aspects, 2010, Volume 16, 95-102, DOI: 10.1007/978-90-481-3892-0_16.

周産期病態研究部

英文原著

  1. Maehara, K., Takahashi, K., and Saitoh, S. (2010) CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Mol Cell Biol. 30, 2090-2104.
  2. Yamazawa, K., Nakabayashi, K., Matsuoka, K., Masubara, K., Hata, K., Horikawa, R., and Ogata, T.(2011) Androgenetic/biparental mosaicism in a girl with Beckwith-Wiedemann syndrome-like and upd(14)pat-like phenotypes. J Hum Genet. 56, 91-93. Epub 2010 Nov 11.
  3. Yamazawa K#,Nakabayashi K#, Kagami M, Sato T, Saitoh S, HorikawaR, Hizuka N, Ogata T. (2010) Parthenogenetic chimaerism/mosaicism with a Silver-Russell Syndrome-like phenotype. J. Med. Genet. (in press) (#equal contribution)

成育社会医学研究部

英文原著

  1. Iwase T, Suzuki E, Fujiwara T, Takao S, Doi H, Kawachi I. Do bonding and bridging social capital have differential effects on self-rated health? A community based study in Japan. J Epidemiol Community Health 2010; Epub ahead in print.
  2. Akalanka, EC, Fujiwara T, Desapriya E, Peiris DC, Scime G, Pike I. Sociodemographic factors associated with aggressive driving behaviors of three wheeler taxi drivers in Sri Lanka. Asia-Pacific Journal of Public Health 2010; Epub ahead in print.
  3. Desapriya E, Fujiwara T, Verma P, Pike I. Comparison of on-reserve road versus off-reserve road motor vehicle crashes in Saskatchewan, Canada: a case control study. Asia-Pacific Journal of Public Health. 2010; Epub ahead in print
  4. Fujiwara T, Okuyama K, Izumi M. The cycle of violence: childhood abuse history, domestic violence and child maltreatment among Japanese mothers. Psychologia. 2010;53:211-224.
  5. Suzuki E, Fujiwara T, Takao S, Subramanian SV, Yamamoto E, Kawachi I. Workplace social capital and smoking among Japanese private sector employees: a multilevel study. BMC Public Health. 2010;10:489.
  6. Ueshima K, Fujiwara T, Takao S, Suzuki E, Iwase T, Doi H. Does Individual-level Social Capital Promote Physical Activity? A Population-based Study in Japan. PLoS One. 2010;5(8): e12135.
  7. Fujiwara T, Nagase H, Okuyama M, Hoshino T, Aoki K, Nagashima T, Nakamura H. Validity of caregivers’ reports on head trauma due to falls in young children aged less than 2 years. Clinical Medicine Insights: Pediatrics. 2010:4 11-18.
  8. Fujiwara T, Okuyama M, Izumi M, Osada Y. The impact of childhood abuse history and domestic violence on the mental health of women in Japan. Child Abuse & Neglect. 2010;34:267-74.
  9. Fujiwara T, Okuyama M, Takahashi K. Paternal involvement in childcare and unintentional injury of young children: a population-based cohort study in Japan. Int J Epidemiol. 2010;39(2):588-97.
  10. S.Fuse,T.Kobayasi,Y.Arakaki,S.Ogawa,H.Kato,N.Sakamoto,K.Hamaoka,T.Saji. Standard method for ultrasound imaging of coronary artery in children.  Pediatrics International 2010:52(6);876-882
  11. U.Yamborisut,N.Sakamoto.Wanphen Wimonpeerapattana, Kraisid Tontisirin. Waist circumference and body fat distribution indexes as screening tools for the overweight and obesity in Thai preschool children.Obesity Research & Clinical Practice 2010:4(4);e307-e314
  12. Y.Ishida,N.Sakamoto,K.Kamibeppu,N.Kakee,T.Iwai,S.Ozono,N.Maeda,J.Okamura,K.Asami,H.Inada,M.Honda, K.Horibe. Late effects and quality of life of Childhood cancer survivors:Part2 Impact of radiotherapy. International Journal of Hematology 2010:92(1);95-104
  13. K.Kamibeppu,I.Sato,M.Honda,S.Ozono,N.Sakamoto,T.Iwai,J.Okamura,K.Asami,N.Maeda,H.Inada,N.Kakee,K.Horibe,Y.Ishida. Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth. Journal of Cancer Survivorship 2010:4(4);303-312
  14. Y.Ishida,M.Honda,S.Ozono,J.Okamura,K.Asami,N.Maeda,N.Sakamoto,H.Inada,T.Iwai,K.Kamibeppu,N.Kakee,K.Horibe. Late effects and quality of life of Childhood cancer survivors:Part1 Impact of the stem cell transplantation. International Journal of Hematology 2010:91(5);865-875.
  15. L.Yang, J.Fujimoto, D.Qiu, N.Sakamoto. Trends in cancer mortality in the elderly in Japan, 1970-2007. Annals of Oncology 2010:21(2);389-396.
  16. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Nishida N, Tsuchiya N, Ohtsuka R, Ohashi J. The Q223R Polymorphisms in LEPR is associated with obesity in Pacific Islanders. Human Genetics 2010, 127(3);287-294
  17. Nagako Okuda, Katsuyuki Miura, Katsushi Yoshita, Yasuhiro Matsumura, Akira Okayama, Yasuyuki Nakamura, Tomonori Okamura, Shigeyuki Saitoh, Kiyomi Sakata, Toshiyuki Ojima, Tanvir Chowdhury Turin, Hirotsugu Ueshima, for the NIPPON DATA80/90 Research Group. Integration of data from NIPPON DATA80/90 and National Nutrition Survey in Japan: for cohort studies of representative Japanese on Nutrition. J Epidemioll 2010, 20(Suppl.3); S505-S514
  18. Yasuyuki Nakamura, Nagako Okuda, Tanvir Chowdhury Turin, Akira Fujiyoshi, Tomonori Okamura, Takehito Hayakawa, Yasuhiro Matsumura, Katsuyuki Miura, Hirotsugu Ueshima  for the NIPPON DATA80/90 Research Group. Comparison of the National Nutritional Survey in Japan Estimated Individual-Based Nutritional Data and NIPPON DATA80 Food Frequency Questionnaires. J Epidemiol 2010, 20(Suppl.3); S582-S586
  19. Shirado O, Doi T, Akai M, Hoshino Y, Fujino K, Hayashi K, Marui E, Iwaya T: Multicenter randomized controlled trial to evaluate theeffect of home-based exercise on patients with chronic low back pain-The Japan Low Back Pain Exercise Therapy Study. Spine 35(17): 811-9, 2010
  20. Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Hayashi K: A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension0.1% in severe allergic conjunctivitis. Journal of Ocular Pharmacologyand Therapeutics 26 (2): 165-174, 2010.
  21. Takai Y, Yamamoto-Mitani N, Chiba Y, Nishikawa Y, Hayashi K, Sugai Y. Abbey Pain Scale: Development and validation of the Japanese version. Geriatrics & Gerontology International 10(2): 145-53, 2010. 

成育政策科学研究部

英文原著

  1. Tomohiro Saito, Hiroshi Nitta, Osami Kubo, et al. Power-frequency magnetic fields and childhood brain tumors: A case-control study in Japan. J Epidemiol 20(1):54-61,2010.
  2. Kheifets L, Ahlbom A, Crespi CM, Feychting M, Johansen C, Monroe J, Murphy MF , Oksuzyan S, Preston-Martin S, Roman E, Saito T, Savitz D, Schuz J, Simpson J, Swanson J, Tynes T, Verkasalo P, Mezei G. A pooled analysis of extremely low-frequency magnetic fields and childhood brain tumors. Am J Epidemiol Oct.1 172(7):752-61,2010.
  3. Yasushi Ishida, Misato Honda, Shuichi Ozono, Jun Okamura, Keiko Asami, Naoko Maeda, Naoko Sakamoto, Hiroko Inada, Tsuyako Iwai, Kiyoko Kamibeppu, Naoko Kakee, Keizo Horibe: Late effects and quality of life of childhood cancer survivors: Part 1. Impact of stem cell transplantation. The Japanese Society of Hematology 91:865-876,2010.
  4. Yasushi Ishida, Naoko Sakamoto, Kiyoko Kamibeppu, Naoko Kakee, Tsuyako Iwai, Shuichi Ozono, Naoko Maeda, Jun Okamura, Keiko Asami, Hiroko Inada, Misato Honda, Keiizo Horibe: Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy. The Japanese Society of Hematology 92:95-104,2010.
  5. Fujii C, Sato Y, Harada S, Kakee N, Gu YH, Kato T, Shintaku H, Owada M, Hirahara F, Umehashi H, Yoshino M. Attitude to extended use and long-term storage of newborn screening blood spots in Japan. Pediatr Int. Jun;52(3):393-397,2010.
  6. Gu Yan-Hong, Kato Tadaaki, Harada Shohei, Inomata Hiroaki, and Aoki Kikumaro. Time Trend and Geographic Distribution of Treated Patients with Congenital Hypothyroidism Relative to the Number of Available Endocrinologists in Japan. The Journal of Pediatrics. July;157(1):53-157,2010.
  7. Nakamura Y, Yashiro M, Ae Y, Chihara I, Sadakane A, Aoyama Y, Kotani K, Uehara R, Harada S. Characteristics and Validity of a Web-Based Kawasaki Disease Surveillance System in Japan. J Epidemiol;20(6):429-432,2010.
  8. )Kamibeppu K, Sato I, Honda M, Ozono S, Sakamoto N, Iwai T, Okamura J, Asami K, Maeda N, Inada H, Kakee N, Horibe K, Ishida Y. Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growth. Journal of Cancer Survivorship; 4(4) :303-312, 2010.

再生医療センター

英文原著

  1. Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A. Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development. Hum Mol Genet. 2010; 19(3):480-493.
  2. Yazawa T, Inaoka Y, Okada R, Mizutani T, Yamazaki Y, Usami Y, Kuribayashi M, Orisaka M, Umezawa A, Miyamoto K. PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1. Mol Endocrinol. 2010; 24(3):485-496.
  3. Ikegami Y, Miyoshi S, Nishiyama N, Hida N, Okamoto K, Miyado K, Segawa K, Ogawa S, Umezawa A. Serum-independent cardiomyogenic transdifferentiation in human endometrium-derived mesenchymal cells. Artif Organs. 2010; 34(4):280-288.
  4. Fujino T, Nomura K, Ishikawa Y, Makino H, Umezawa A, Aburatani H, Nagasaki K, Nakamura T. Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance. Am J Pathol. 2010; 176(4):1973-1982.
  5. Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010; 465(7295):175-181.
  6. Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, Suzuki J, Satake M, Nakamizo H, Tanaka M, Mori T, Segawa K, Nishiyama N, Inoue J, Makino H, Miyado K, Ogawa S, Yoshimura Y, Umezawa A. Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes. Circ Res. 2010; 106(10):1613-1623.
  7. Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A. Cells of extraembryonic mesodermal origin confer human dystrophin in the mdx model of Duchenne muscular dystrophy. J Cell Physiol. 2010; 223(3):695-702.
  8. Ito C, Yamatoya K, Yoshida K, Maekawa M, Miyado K, Toshimori K. Tetraspanin family protein CD9 in the mouse sperm: unique localization, appearance, behavior and fate during fertilization. Cell Tissue Res. 2010; 340(3):583-594.
  9. Haraguchi Y, Sekine W, Shimizu T, Yamato M, Miyoshi S, Umezawa A, Okano T. Development of a new assay system for evaluating the permeability of various substances through three-dimensional tissue. Tissue Eng Part C Methods. 2010; 16(4):685-692.
  10. Adachi T, Wang X, Murata T, Obara M, Akutsu H, Machida M, Umezawa A, Tomita M. Production of a non-triple helical collagen alpha chain in transgenic silkworms and its evaluation as a gelatin substitute for cell culture. Biotechnol Bioeng. 2010; 106(6):860-870.
  11. Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M. Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration. J Neuropathol Exp Neurol. 2010; 69(9):973-985.
  12. Kawano N, Kang W, Yamashita M, Koga Y, Yamazaki T, Hata T, Miyado K, Baba T. Mice lacking two sperm serine proteases, ACR and PRSS21, are subfertile, but the mutant sperm are infertile in vitro. Biol Reprod. 2010; 83(3):359-369.
  13. Mizutani T, Yazawa T, Ju Y, Imamichi Y, Uesaka M, Inaoka Y, Matsuura K, Kamiki Y, Oki M, Umezawa A, Miyamoto K. Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (StAR) gene that participates in SF-1-dependent chromatin architecture. J Biol Chem. 2010; 285(36):28240-28251.
  14. Wang S, Kawashima N, Sakamoto K, Katsube K, Umezawa A, Suda H. Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj. Biochem Biophys Res Commun. 2010; 400(1):39-45.
  15. Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A. Defining hypo-methylated regions of stem cell-specific promoters in human iPS cells derived from extra-embryonic amnions and lung fibroblasts. PLoS One. 2010; 5(9):e13017.
  16. Sasaki N, Hirano T, Kobayashi K, Toyoda M, Miyakawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nishihara S. Chemical inhibition of sulfation accelerates neural differentiation of mouse embryonic stem cells and human induced pluripotent stem cells. Biochem Biophys Res Commun. 2010; 401(3):480-486.
  17. Ito M, Miyado K, Nakagawa K, Muraki M, Imai M, Yamakawa N, Qin J, Hosoi Y, Saito H, Takahashi Y. Age-associated changes in the subcellular localization of phosphorylated p38 MAPK in human granulosa cells. Mol Hum Reprod. 2010; 16(12):928-937.
  18. Chowdhury MM, Katsuda T, Montagne K, Kimura H, Kojima N, Akutsu H, Ochiya T, Fujii T, Sakai Y. Enhanced effects of secreted soluble factor preserve better pluripotent state of embryonic stem cell culture in a membrane-based compartmentalized micro-bioreactor. Biomed Microdevices. 2010; 12(6):1097-1105.
  19. Shinmura D, Togashi I, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H, Nakamizo H, Segawa K, Tsukada Y, Ogawa S, Umezawa A. Pretreatment of Human Mesenchymal Stem Cells with Pioglitazone Improved Efficiency of Cardiomyogenic Transdifferentiation and Improved Cardiac Function. Stem Cells. 2010 (in press).
  20. Toyoda M, Yamazaki-Inoue M, Itakura Y, Kuno A, Ogawa T, Yamada M, Akutsu H, Takahashi Y, Kanzaki S, Narimatsu H, Hirabayashi J, Umezawa A. Lectin microarray analysis of pluripotent and multipotent stem cells. Genes Cells. 2010 (in press).
  21. Cui CH, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, Terai M, Suzuki H, Umezawa A. Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy. Hum Mol Genet. 2010 (in press).
  22. Miyagawa Y, Okita H, Hiroyama M, Sakamoto R, Kobayashi M, Nakajima H, Katagiri YU, Fujimoto J, Hata J, Umezawa A, Kiyokawa N. A microfabricated scaffold induces the spheroid formation of human bone marrow-derived mesenchymal progenitor cells and promotes efficient adipogenic differentiation. Tissue Eng Part A. 2010 (in press).
  23. Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T, Furue MK, Mizuguchi H. Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther. 2010 (in press).
  24. Yazawa T, Kawabe S, Inaoka Y, Okada R, Mizutani T, Imamichi Y, Ju Y, Yamazaki Y, Usami Y, Kuribayashi M, Umezawa A, Miyamoto K. Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1. Mol Cell Endocrinol. 2010 (in press).
  25. Miyamoto K, Yazawa T, Mizutani T, Imamichi Y, Kawabe SY, Kanno M, Matsumura T, Ju Y, Umezawa A. Stem cell differentiation into steroidogenic cell lineages by NR5A family. Mol Cell Endocrinol. 2010 (in press).

英文総説・著書

  1. Toyoda M, Hamatani T, Okada H, Matsumoto K, Saito H, Umezawa A. Defining cell identity by comprehensive gene expression profiling. Curr Med Chem. 2010; 17(28):3245-3252.
  2. Umezawa A, Gorham JD. Dueling models in head and neck tumor formation. Lab Invest. 2010; 90(11):1546-1548.
  3. Kawano N., Harada Y., Yoshida K., Miyado M., Miyado K. Role of CD9 in sperm-egg fusion and its general role in fusion phenomena, Cell Fusions: Regulation and Control. Larsson, Lars-Inge (ed). Springer., 171-184, 2010.
  4. Kawano N, Yoshida K, Miyado K, Yoshida M. Lipid Rafts: Keys to SpermMaturation, Fertilization, and Early Embryogenesis. Journal of Lipids, in press.

共同研究管理室

英文原著
[論文発表]

  1. Prevention of graft-versus-host diseases by in vivo supCD28mAb-expanded antigen-specific nTreg cells. Kitazawa Y, Li XK, Liu Z, Kimura H, Isaka Y, Hünig T, Takahara S. Cell Transplant. 2010;19(6):765-74. Epub 2010 Jun 23.

RI管理室

英文原著

  1. Miyasato K, Takabatake Y, Kaimori J, Kimura T, Kitamura H, Kawachi H, Li X-K, Hünig T, Takahara S, Rakugi H, Isaka Y CD28 superagonist-induced regulatory T cell expansion ameliorates mesangioproliferative glomerulonephritis in rats. Clin Exp Nephrol. 15(1): 50-7; 2010.
  2. Azuma H, Isaka Y, Nomi H, Inamoto T, Li X-K, Hőunig T, Takabatake Y, Ichimaru N, Ibuki N, Matsumoto K, Ubai T, Katsuoka Y, Takahara S. Induction of Donor-Specific Tolerance Using Superagonistic CD28 Antibody in Rat Renal Allografts: Regulatory T-Cell Expansion Before Engraftment May Be Important. Transplantation 90 (12): 1328-1335; 2010.
  3. Kitazawa Y, Li X-K*, Liu Z, Kimura H, Isaka Y, Hunig T, Takahara S. Prevention of graft-versus-host diseases by in vivo supCD28mAb-expanded antigen-specific nTreg cells. Cell Transplant 19(6): 765-74; 2010. (*Corresponding author).
  4. Morita M, Fujino M, Jiang GP, Kitazawa Y, Xie L, Azuma M, Yagita H, Nagao S, Sugioka A, Kurosawa Y, Takahara S, Fung J, Qian S, Lu L, Li X-K. PD1/B7-H1 interaction contribute to the spontaneous acceptance of mouse liver allograft. Am J Transplant 10(1): 40-46; 2010.

英文総説・著書

  1. Xie L, Li X-K*, Takahara S. Curcumin has bright prospects for the treatment of multiple sclerosis. Int Immunopharmacol. (In press). (*Corresponding author)
  2. Immunosuppressive and anti-inflammatory activities of sinomenine. Wang Q, Li X-K*. Int Immunopharmacol. (In press) (*Corresponding author)