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Division of Radiation Safety
Our division investigates the fundamental events of immune cells during immune response to transplantation antigens and ischemia/reperfusion injury. We aim to understand the basic processes that control T-cell activation and tolerance, and develop novel immunosuppressive agents, antibodies, and siRNA using rodent heart and liver transplantation models. We have also proposed several new approaches for cell-based immunotherapy, including iPS-cell-derived regulatory dendritic cells, myeloid-derived suppressor cells, mesenchymal stem cells, and gene therapy in transplant rejection. Furthermore, we have developed a novel non-invasive positron emission tomography (PET) imaging method for the evaluation of acute allograft rejection and immunosuppressive therapy efficacy. We are currently building a biomarker search system for liver transplantation patients.
Through our research, we aim to:
- Gain mechanistic insights into immune tolerance induction and maintenance;
- Establish new approaches for cell-based immunotherapy;
- Develop novel biomarkers and methods for transplant rejection diagnosis;
- Create novel immunosuppressive agents, antibodies, siRNA, etc.;
- Devise new solutions and methods for organ preservation.